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17-02-2016 | Gynecologic cancers | Article

Ovarian cancer survivors’ quality of life: a systematic review

Journal: Journal of Cancer Survivorship

Authors: D. Ahmed-Lecheheb, F. Joly

Publisher: Springer US

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Abstract

Purpose

The assessment of quality of life (QOL) among ovarian cancer (OC) patients has mainly focused on the acute phase of treatment. This systematic review examines studies measuring QOL in patients who survived OC after treatment and synthesizes results in order to assess QOL and patient-reported outcome (PRO) data at long-term follow-up.

Methods

Articles published in English between 1990 to November 2014 were identified with the databases MEDLINE and PubMed, using the specific keywords “OC survivors” combined with the terms, “QOL,” “health-related QOL,” and “PROs.” Data were reviewed for design, time since end of treatment, measurement tools, and outcomes (categorized in three topics: global QOL compared to controls, treatment sequelae, and intervention strategies).

Results

The initial search strategy provided 148 articles of which 31 were considered eligible. Most studies focused on epithelial OC, and only a few studies investigated survivors of ovarian germ cell tumor. More than 60 instruments of QOL measures were used in the corpus. Despite the persistence of psychological and physical symptoms, treatment sequelae, sexual problems, and fear of recurrence in some survivors, most studies demonstrated that OC survivors generally have good QOL compared to healthy women. Studies proposing interventions are lacking.

Conclusions and Implications for Cancer Survivor

OC survivors experience a wide range of sequelae that may persist for a long time and negatively impact QOL. Further large-scale research is needed to fully understand problems that have significant effects on QOL, in order to develop interventions and treatments suitable for women at need.
Literature
1.
Les cancers en France en 2013. Collection État des lieux et des connaissances, ouvrage collectif édité par l’INCa, Boulogne-Billancourt, janvier 2014.
2.
Grosclaude P, Remontet L, Belot A, Danzon A, Rasamimanana-Cerf N, Bossard N. Survie des personnes atteintes de cancer en France, 1989-2007–Étude à partir des registres des cancers du réseau Francim. Saint-Maurice: Institut de veille sanitaire; 2013. 412 p. Available at: http://​opac.​invs.​sante.​fr/​doc_​num.​php?​explnum_​id=​8758. Accessed May 12, 2015.
3.
Hess LM, Stehman FB. State of the science in ovarian cancer quality of life research: a systematic review. Int J Gynecol Cancer. 2012;22(7):1273–80.PubMedCrossRef
4.
Penson RT, Wenzel LB, Vergote I, et al. Quality of life considerations in gynecologic cancer. FIGO 6th annual report on the results of treatment in gynecological cancer. Int J Gynaecol Obstet. 2006;95, S247YS257.CrossRef
5.
Sanders C, Egger M, Donovan J, et al. Reporting on quality of life in randomised controlled trials: bibliographic study. BMJ. 1998;317:1191–4.PubMedPubMedCentralCrossRef
6.
Lockwood-Rayermann S. Survivorship issues in ovarian cancer: a review. Oncol Nurs Forum. 2006;33(3):553–62.PubMedCrossRef
7.
Roland KB, Rodriguez JL, Patterson JR, Trivers KF. A literature review of the social and psychological needs of ovarian cancer survivors. Psychooncology. 2013;22(11):2408–18.PubMedCrossRef
8.
Smith HO, Berwick M, Verschraegen CF, Wiggins C, Lansing L, Muller CY, et al. Incidence and survival rates for female malignant germ cell tumors. Obstet Gynecol. 2006;107:1075–85.PubMedCrossRef
9.
Williams S, Blessing JA, Liao S, Ball H, Hanjani P. Adjuvant therapy of ovarian germ cell tumors with cisplatin, etoposide, and bleomycin: a trial of the Gynecologic Oncology Group. J Clin Oncol. 1994;12:701–6.PubMed
10.
Swenson MM, MacLeod JS, Williams SD, Miller AM, Champion VL. Quality of life after among ovarian germ cell cancer survivors: a narrative analysis. Oncol Nurs Forum. 2003;30(3):380.PubMedCrossRef
11.
Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol. 2009;62(10):e1–e34.PubMedCrossRef
12.
Moher D, Liberati A, Tetzlaff J, Altman DG, The PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6(6), e1000097.PubMedPubMedCentralCrossRef
13.
Matei D, Miller AM, Monahan P, Gershenson D, Zhao Q, Cella D, et al. Chronic physical effects and health care utilization in long-term ovarian germ cell tumor survivors: a Gynecologic Oncology Group study. J Clin Oncol. 2009;27(25):4142–9.PubMedPubMedCentralCrossRef
14.
Monahan PO, Champion VL, Zhao Q, Miller AM, Gershenson D, Williams SD, et al. Case-control comparison of quality of life in long-term ovarian germ cell tumor survivors: a gynecologic oncology group study. J Psychosoc Oncol. 2008;26(3):19–42.PubMedCrossRef
15.
Gershenson DM, Miller AM, Champion VL, Monahan PO, Zhao Q, Cella D, et al. Reproductive and sexual function after platinum-based chemotherapy in long-term ovarian germ cell tumor survivors: a Gynecologic Oncology Group study. J Clin Oncol. 2007;25(19):2792–7.PubMedCrossRef
16.
Champion V, Williams SD, Miller A, Reuille KM, Wagler-Ziner K, Monahan PO, et al. Quality of life in long-term survivors of ovarian germ cell tumors: a Gynecologic Oncology Group study. Gynecol Oncol. 2007;105(3):687–94.PubMedPubMedCentralCrossRef
17.
Ezendam NP, Pijlman B, Bhugwandass C, Pruijt JF, Mols F, Vos MC, et al. Chemotherapy-induced peripheral neuropathy and its impact on health-related quality of life among ovarian cancer survivors: results from the population-based PROFILES registry. Gynecol Oncol. 2014;135(3):510–7.PubMedCrossRef
18.
Teng FF, Kalloger SE, Brotto L, McAlpine JN. Determinants of quality of life in ovarian cancer survivors: a pilot study. J Obstet Gynaecol Can. 2014;36(8):708–15.PubMedCrossRef
19.
Stavraka C, Ford A, Ghaem-Maghami S, Crook T, Agarwal R, Gabra H, et al. A study of symptoms described by ovarian cancer survivors. Gynecol Oncol. 2012;125(1):59–64.PubMedCrossRef
20.
Paxton RJ, Garcia-Prieto C, Berglund M, Hernandez M, Hajek RA, Handy B, et al. A randomized parallel-group dietary study for stages II-IV ovarian cancer survivors. Gynecol Oncol. 2012;124(3):410–6.PubMedCrossRef
21.
Greimel E, Daghofer F, Petru E. Prospective assessment of quality of life in long-term ovarian cancer survivors. Int J Cancer. 2011;128(12):3005–11.PubMedCrossRef
22.
Mirabeau-Beale KL, Kornblith AB, Penson RT, Lee H, Goodman A, Campos SM, et al. Comparison of the quality of life of early and advanced stage ovarian cancer survivors. Gynecol Oncol. 2009;114(2):353–9.PubMedCrossRef
23.
Stevinson C, Tonkin K, Capstick V, Schepansky A, Ladha AB, Valance JK, et al. A population-based study of the determinants of physical activity in ovarian cancer survivors. J Phys Act Health. 2009;6(3):339–46.PubMedCrossRef
24.
Stevinson C, Capstick V, Schepansky A, Tonkin K, Vallance JK, Ladha AB, et al. Physical activity preferences of ovarian cancer survivors. Psycho-Oncology. 2009;18(4):422–8.PubMedCrossRef
25.
Stevinson C, Steed H, Faught W, Tonkin K, Vallance JK, Ladha AB, et al. Physical activity in ovarian cancer survivors: associations with fatigue, sleep, and psychosocial functioning. Int J Gynecol Cancer. 2009;19(1):73–8.PubMedCrossRef
26.
Stevinson C, Faught W, Steed H, Tonkin K, Ladha AB, Vallance JK, et al. Associations between physical activity and quality of life in ovarian cancer survivors. Gynecol Oncol. 2007;106(1):244–50.PubMedCrossRef
27.
Liavaag AH, Dørum A, Fosså SD, Tropé C, Dahl AA. Morbidity associated with “self-rated health” in epithelial ovarian cancer survivors. BMC Cancer. 2009;9:2.PubMedPubMedCentralCrossRef
28.
Liavaag AH, Dørum A, Bjøro T, Oksefjell H, Fosså SD, Tropé C, et al. A controlled study of sexual activity and functioning in epithelial ovarian cancer survivors. A therapeutic approach. Gynecol Oncol. 2008;108(2):348–54.PubMedCrossRef
29.
Liavaag AH, Dorum A, Fossa SD, Tropé C, Dahl AA. Controlled study of fatigue, quality of life, and somatic and mental morbidity in epithelial ovarian cancer survivors: how lucky are the lucky ones? J Clin Oncol. 2007;25:2049–56.PubMedCrossRef
30.
Fox SW, Lyon D. Symptom clusters and quality of life in survivors of ovarian cancer. Cancer Nurs. 2007;30(5):354–61.PubMedCrossRef
31.
Ferrell B, Cullinane CA, Ervine K, Melancon C, Uman GC, Juarez G. Perspectives on the impact of ovarian cancer: women’s views of quality of life. Oncol Nurs Forum. 2005;32(6):1143–9.PubMedCrossRef
32.
Stewart DE, Wong F, Duff S, Melancon CH, Cheung AM. “What doesn’t kill you makes you stronger”: an ovarian cancer survivor survey. Gynecol Oncol. 2001;83(3):537–42.PubMedCrossRef
33.
Matulonis UA, Kornblith A, Lee H, Bryan J, Gibson C, Wells C, et al. Long-term adjustment of early-stage ovarian cancer survivors. Int J Gynecol Cancer. 2008;18(6):1183–93.PubMedCrossRef
34.
Wenzel LB, Donnelly JP, Foweler JM, Habbal R, Taylor TH, Aziz N, et al. Resilience, reflection, and residual stress in ovarian cancer survivorship: a gynecologic oncology group study. Psycho-Oncology. 2002;11:142–53.PubMedCrossRef
35.
Gross AH, Cromwell J, Fonteyn M, Matulonis UA, Hayman LL. Hopelessness and complementary therapy use in patients with ovarian cancer. Cancer Nurs. 2013;36(4):256–64.PubMedCrossRef
36.
Andersen MR, Sweet E, Lowe KA, Standish LJ, Drescher CW, Goff BA. Involvement in decision-making about treatment and ovarian cancer survivor quality of life. Gynecol Oncol. 2012;124(3):465–70.PubMedCrossRef
37.
Kornblith AB, Mirabeau-Beale K, Lee H, Goodman AK, Penson RT, Pereira L, et al. Long-term adjustment of survivors of ovarian cancer treated for advanced-stage disease. J Psychosoc Oncol. 2010;28(5):451–69.PubMedCrossRef
38.
Otis-Green S, Ferrell B, Sun V, Spolum M, Morgan R, Macdonald D. Feasibility of an ovarian cancer quality-of-life psychoeducational intervention. J Cancer Educ. 2008;23(4):214–21.PubMedCrossRef
39.
Holzner B, Kemmler G, Meraner V, Maislinger A, Kopp M, Bodner T, et al. Fatigue in ovarian carcinoma patients: a neglected issue? Cancer. 2003;97(6):1564–72.PubMedCrossRef
40.
Ferrel B, Smith SL, Cullinane CA, Melancon C. Psychological well-being and quality of life in ovarian cancer survivors. Cancer. 2003;98:1061–71.CrossRef
41.
Ferrell BR, Smith SL, Juarez G, Melancon C. Meaning of illness and spirituality in ovarian cancer survivors. Oncol Nurs Forum. 2003;30(2):249–57.PubMedCrossRef
42.
Ersek M, Ferrell BR, Dow KH, Melancon CH. Quality of life in women with ovarian cancer. West J Nurs Res. 1997;19(3):334–50.PubMedCrossRef
43.
FACIT: view questionnaires and availability. Available at http://​www.​facit.​org/​FACITOrg/​Questionnaires. Accessed April 28, 2015
44.
Basen-Engquist K, Bodurka-Bevers D, Fitzgerald MA, et al. Reliability and validity of the functional assessment of cancer therapy—ovarian. J Clin Oncol. 2001;19:1809–17.PubMed
45.
Ferrell B, Dow KH, Grant M. Measurement of the quality of life in cancer survivors. Qual Life Res. 1995;4(6):523–31.PubMedCrossRef
46.
Waterhouse J, Metcalfe MC. Development of the sexual adjustment questionnaire. Oncol Nurs Forum. 1986;13:53–9.PubMed
47.
Zeltzer LK, Lu Q, Leisenring W, et al. Psychosocial outcomes and health-related quality of life in adult childhood cancer survivors: a report from the childhood cancer survivor study. Cancer Epidemiol Biomarkers Prev. 2008;17(2):435–46.PubMedCrossRef
48.
Ashing-Giwa KT, Tejero JS, Kim J, Padilla GV, Hellemann G. Examining predictive models of HRQOL in a population-based, multiethnic sample of women with breast carcinoma. Qual Life Res. 2007;16(3):413–28.PubMedCrossRef
49.
Sweeney C, Schmitz KH, Lazovich D, Virnig BA, Wallace RB, Folsom AR. Functional limitations in elderly female cancer survivors. J Natl Cancer Inst. 2006;98(8):521–9.PubMedCrossRef
50.
Carmack Taylor CL, Basen-Engquist K, Shinn EH, Bodurka DC. Predictors of sexual functioning in ovarian cancer patients. J Clin Oncol. 2004;22:881–9.PubMedCrossRef
51.
Brotto LA, Heiman JR. Mindfulness in sex therapy: applications for women with sexual difficulties following gynecologic cancer. Sex Relationship Ther. 2007;22:1468–994.
52.
Andersen BL. Psychological interventions for cancer patients to enhance the quality of life. J Consult Clin Psychol. 1992;60:552.PubMedPubMedCentralCrossRef
53.
Weis J. Support groups for cancer patients. Support Care Cancer. 2003;11:63–8.CrossRef