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ROS1 fusion-positive NSCLC

Luis Paz-Ares, Jaime Schneider, and Benjamin Besse discuss the management of ROS1 fusion-positive NSCLC in patients based in Europe and the USA.

00:00 Introduction 
01:12 Testing for ROS1 fusions
08:43 Treatment of ROS1 fusion-positive NSCLC
14:17 CNS metastases
16:15 On progression
19:44 Next-generation agents
23:22 Thromboprophylaxis
25:25 Chemotherapy and immunotherapy
31:32 The need to understand etiology
32:45 Combating resistance


Meet the faculty

Faculty disclosures

Faculty disclosures

Luis Paz-Ares

Leadership: Genomica (external member of the board), Altum Sequencing (founding partner and member of the board)

Travel, accommodation, expenses: Roche, AstraZeneca, MSD, Bristol-Myers Squibb, Lilly, Pfizer

Honoraria: Roche/Genentech, Lilly, Pfizer, Bristol-Myers Squibb, MSD, BMS, AstraZeneca, Merck Serono, PharmaMar, Novartis, Celgene, Amgen, Mirati, Abbvie

Other relationship (immediate family member): Novartis, Ipsen, Pfizer, Servier, Sanofi, Roche, Amgen, Merck

Jaime Schneider

Declares no conflict of interest

Benjamin Besse

Sponsored Research at Gustave Roussy Cancer Center: 4D Pharma, Abbvie, Amgen, Aptitude Health, AstraZeneca, BeiGene, Blueprint Medicines, Boehringer Ingelheim, Celgene, Cergentis, Chugai pharmaceutical, Cristal Therapeutics, Daiichi-Sankyo, Eli Lilly, EISAI, Genzyme Corporation, GSK, Inivata, IPSEN, Janssen, Onxeo, OSE immunotherapeutics, Pfizer, Roche-Genentech, Sanofi, Takeda, Tolero Pharmaceuticals, Turning Point Therapeutics

Funding and disclaimer

Funding and disclaimer

This content is intended only for healthcare providers and was made possible by educational funding provided by F. Hoffmann-La Roche Ltd.

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