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a premier resource for the latest clinical information in medicine.

medwireNews editor's pick

IMpassion130 supports atezolizumab use in triple-negative breast cancer

IV drip_patient's hand

Results for the IMpassion130 trial support the combination of atezolizumab and nab-paclitaxel for the treatment of metastatic triple-negative breast cancer, especially among patients with programmed cell death ligand 1-positive disease.

medwireNews editor's pick

Endocrine therapy impacts cardiovascular risk in women with breast cancer

Heart and white pills

Long-term use of adjuvant endocrine therapy by women with a history of nonmetastatic breast cancer can significantly alter their risk for some types of cardiovascular disease, a meta-analysis shows.

Expert opinion

Developing polygenic risk scores for breast cancer

3D illustration of a method of DNA sequencing

Gareth Evans (University of Manchester, UK) details how genetic advances have allowed the development of relatively cheap and clinically meaningful genetic-based scores for breast cancer risk, further heralding the shift towards precision medicine in breast cancer.

Expert opinion

Breast cancer-related lymphedema management: Current state and future directions

Lymphedema management

Breast cancer-related lymphedema is a debilitating complication of breast cancer surgery. Babak Mehrara (Memorial Sloan Kettering Cancer Center, NY, USA) outlines the current state of lymphedema management and poses some questions for the future.

Expert opinion

Challenges of an aging and increasingly obese breast cancer survivor population: Are we ready?

Obesity and breast cancer

In an aging population with rising obesity levels, comorbidities and worse overall prognoses for breast cancer patients are a growing concern. Damien Hansra (Cancer Treatment Centers of America, GA, USA) calls for more education and preparation to combat this concerning public health threat.

02-05-2019 | Radiotherapy | News

Biologic, genetic markers predict radiation toxicity in oncology patients

A combination of biologic and genetic markers may be useful to predict which patients will experience toxicity following radiotherapy, suggest data presented at the ESTRO 38 conference in Milan, Italy.

23-04-2019 | Oligometastases | News

SABR may improve survival in oligometastatic cancer

The phase II SABR-COMET study has indicated that stereotactic ablative radiotherapy prolongs overall and progression-free survival versus palliative treatment in patients with up to five oligometastases.

04-04-2019 | TRK inhibitors | AACR 2019 | News

LOXO-195 could be an option for tumors resistant to first-generation TRK inhibitors

Early findings point to the antitumor efficacy of the next-generation TRK inhibitor LOXO-195 in patients with NTRK fusion-positive cancers and NTRK resistance mutations acquired during treatment with first-generation agents.

Themed collections

11-04-2018 | Liquid biopsy | Themed collection | Collection

Liquid biopsy in oncology

This themed content collection highlights the role of liquid biopsy in the management of patients with solid tumors and evaluates the role of liquid biopsy in different types of cancer.

14-08-2017 | Breast cancer | Themed collection | Collection

Heterogeneity of triple-negative breast cancer: Implications for therapy

This themed content collection focuses on recent advances in our understanding of the molecular and biological features of triple negative breast cancer and potential therapeutic strategies and novel approaches to targeted therapy.

Journal articles and book chapters

04-01-2019 | Supportive care | Article

Cognitive effects of adjuvant endocrine therapy in older women treated for early-stage breast cancer: a 1-year longitudinal study

Underwood EA et al. Support Care Cancer 2019; 27: 3035. doi:10.1007/s00520-018-4603-5

20-10-2018 | Psychosocial | Article

Systematic review of genetic polymorphisms associated with psychoneurological symptoms in breast cancer survivors

Yang GS, Kumar S, Dorsey SG et al. Support Care Cancer 2019; 27: 351. doi:10.1007/s00520-018-4508-3

24-09-2018 | Breast cancer | Article

Progress in adjuvant systemic therapy for breast cancer

Pondé NF, Zardavas D, Piccart M. Nat Rev Clin Oncol 2018. doi:10.1038/s41571-018-0089-9

18-08-2018 | Breast cancer | Article

“It still affects our economic situation”: long-term economic burden of breast cancer and lymphedema

Dean LT, Moss SL, Ransome Y et al. Support Care Cancer 2019; 27: 1697. doi:10.1007/s00520-018-4418-4

27-07-2018 | Advanced breast cancer | Article

CDK4/6 inhibitors in advanced hormone receptor-positive/HER2-negative breast cancer: a systematic review and meta-analysis of randomized trials

Messina C et al. Breast Cancer Res Treat 2018; 172: 9. doi:10.1007/s10549-018-4901-0

Images and illustrations

12-04-2018 | Breast cancer | Images and illustration slides | Collection

Breast mammography

This downloadable powerpoint slide set comprises a collection of high quality images that depict the use of mammography in breast cancer screening and diagnosis. These slides can be used for reference purposes or for inclusion in one’s own slide sets. Slide notes are included where appropriate. Source: Bassett LW et al. Breast Imaging. In: Jatoi I, Kaufmann M, eds. Management of Breast Diseases. Springer Berlin Heidelberg.

Image Credits