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Expert opinion

Developing polygenic risk scores for breast cancer

3D illustration of a method of DNA sequencing

Gareth Evans (University of Manchester, UK) details how genetic advances have allowed the development of relatively cheap and clinically meaningful genetic-based scores for breast cancer risk, further heralding the shift towards precision medicine in breast cancer.

medwireNews editor's pick

TGFB1 gene key determinant of breast fibrosis risk


Carriers of the C−509T allele in the transforming growth factor ß 1 gene have a significantly increased risk for late breast fibrosis following breast-conserving surgery and whole-breast irradiation for stage 0 to IIA breast cancer, researchers report.

medwireNews editor's pick

Assisted reproduction linked to increased breast and ovarian cancer risk


Women who undergo assisted reproduction may be at increased risk for in situ breast cancer, and invasive and borderline ovarian tumors, show results of a large, population-based study.

Expert opinion

Breast cancer-related lymphedema management: Current state and future directions

Lymphedema management

Breast cancer-related lymphedema is a debilitating complication of breast cancer surgery. Babak Mehrara (Memorial Sloan Kettering Cancer Center, NY, USA) outlines the current state of lymphedema management and poses some questions for the future.


Breast cancer coverage at ASCO Annual Meeting 2018

ASCO 2018
Expert opinion

Challenges of an aging and increasingly obese breast cancer survivor population: Are we ready?

Obesity and breast cancer

In an aging population with rising obesity levels, comorbidities and worse overall prognoses for breast cancer patients are a growing concern. Damien Hansra (Cancer Treatment Centers of America, GA, USA) calls for more education and preparation to combat this concerning public health threat.

18-09-2018 | EMA | News

Durvalumab, abemaciclib approvals announced by EMA

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03-09-2018 | Advanced breast cancer | News

EMBRACA results demonstrate talazoparib advanced breast cancer benefits

The PARP inhibitor talazoparib extends progression-free survival and improves quality of life compared with standard chemotherapy, show findings from the phase III EMBRACA study of women with advanced breast cancer and a germline BRCA1/2 mutation.

31-08-2018 | Breast cancer | News

In other news: Breast cancer treatment effects

The focus this month is on early and late treatment effects in patients with breast cancer, including effects on endometrial cancer risk, cardiotoxicity, and skin toxicity.

Themed collections

30-05-2018 | Breast cancer | Themed collection | Collection

Best of JCO™ 2017: Breast Cancer Edition

Here we provide free-to-access, full-text, original research articles published in Journal of Clinical Oncology that are some of the most-accessed in the area of breast cancer. The articles cover a range of topics including hormone receptor-positive breast cancer, triple-negative breast cancer and molecular imaging.

11-04-2018 | Liquid biopsy | Themed collection | Collection

Liquid biopsy in oncology

This themed content collection highlights the role of liquid biopsy in the management of patients with solid tumors and evaluates the role of liquid biopsy in different types of cancer.

14-08-2017 | Breast cancer | Themed collection | Collection

Heterogeneity of triple-negative breast cancer: Implications for therapy

This themed content collection focuses on recent advances in our understanding of the molecular and biological features of triple negative breast cancer and potential therapeutic strategies and novel approaches to targeted therapy.

Journal articles and book chapters

28-06-2018 | PARP inhibitors | Article

Synthetic lethal therapies for cancer: what’s next after PARP inhibitors?

Ashworth A. Lord CJ. Nat Rev Clin Oncol 2018. doi:10.1038/s41571-018-0055-6

27-06-2018 | Targeted therapy | Article

Selection of Optimal Adjuvant Chemotherapy and Targeted Therapy for Early Breast Cancer: ASCO Clinical Practice Guideline Focused Update

Denduluri N et al. J Clin Oncol 2018; JCO2018788604. doi:10.1200/JCO.2018.78.8604

04-06-2018 | Breast cancer | Article

BRCA1/2 testing: therapeutic implications for breast cancer management

Tung NM, Garber JE. Br J Cancer 2018. doi:10.1038/s41416-018-0127-5

04-06-2018 | Cancer immunotherapy | Article

Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer

Zacharakis N et al. Nat Med 2018; 24: 724–730. doi:10.1038/s41591-018-0040-8

Images and illustrations

12-04-2018 | Breast cancer | Images and illustration slides | Collection

Breast mammography

This downloadable powerpoint slide set comprises a collection of high quality images that depict the use of mammography in breast cancer screening and diagnosis. These slides can be used for reference purposes or for inclusion in one’s own slide sets. Slide notes are included where appropriate. Source: Bassett LW et al. Breast Imaging. In: Jatoi I, Kaufmann M, eds. Management of Breast Diseases. Springer Berlin Heidelberg.

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