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a premier resource for the latest clinical information in medicine.

medwireNews editor's pick

IMpassion130 supports atezolizumab use in triple-negative breast cancer

IV drip_patient's hand

Results for the IMpassion130 trial support the combination of atezolizumab and nab-paclitaxel for the treatment of metastatic triple-negative breast cancer, especially among patients with programmed cell death ligand 1-positive disease.

medwireNews editor's pick

Endocrine therapy impacts cardiovascular risk in women with breast cancer

Heart and white pills

Long-term use of adjuvant endocrine therapy by women with a history of nonmetastatic breast cancer can significantly alter their risk for some types of cardiovascular disease, a meta-analysis shows.

Expert opinion

Developing polygenic risk scores for breast cancer

3D illustration of a method of DNA sequencing

Gareth Evans (University of Manchester, UK) details how genetic advances have allowed the development of relatively cheap and clinically meaningful genetic-based scores for breast cancer risk, further heralding the shift towards precision medicine in breast cancer.

Expert opinion

Breast cancer-related lymphedema management: Current state and future directions

Lymphedema management

Breast cancer-related lymphedema is a debilitating complication of breast cancer surgery. Babak Mehrara (Memorial Sloan Kettering Cancer Center, NY, USA) outlines the current state of lymphedema management and poses some questions for the future.

Expert opinion

Challenges of an aging and increasingly obese breast cancer survivor population: Are we ready?

Obesity and breast cancer

In an aging population with rising obesity levels, comorbidities and worse overall prognoses for breast cancer patients are a growing concern. Damien Hansra (Cancer Treatment Centers of America, GA, USA) calls for more education and preparation to combat this concerning public health threat.

06-11-2018 | Breast cancer | News

Early risers may have reduced breast cancer risk

Women who function better earlier in the day, so-called morning people, are less likely to develop breast cancer than those who consider themselves night owls, suggests a Mendelian randomization analysis.

06-11-2018 | Chemoprevention | News

Run-in period may improve adherence to aspirin for chemoprevention

In patients undergoing radical therapy for cancer, an 8-week run-in period of aspirin is acceptable and well tolerated, and could reduce the risk for nonadherence and participant attrition in adjuvant and prevention trials, say researchers.

05-11-2018 | Breast cancer | ESMO 2018 | News

Epigenetic therapy shows promise for HR-positive advanced breast cancer

Supplementing exemestane with the selective histone deacetylase inhibitor chidamide significantly prolongs the progression-free survival of women with hormone receptor-positive, HER2-negative advanced breast cancer, phase III trial findings indicate.

Themed collections

30-05-2018 | Breast cancer | Themed collection | Collection

Best of JCO™ 2017: Breast Cancer Edition

Here we provide free-to-access, full-text, original research articles published in Journal of Clinical Oncology that are some of the most-accessed in the area of breast cancer. The articles cover a range of topics including hormone receptor-positive breast cancer, triple-negative breast cancer and molecular imaging.

11-04-2018 | Liquid biopsy | Themed collection | Collection

Liquid biopsy in oncology

This themed content collection highlights the role of liquid biopsy in the management of patients with solid tumors and evaluates the role of liquid biopsy in different types of cancer.

14-08-2017 | Breast cancer | Themed collection | Collection

Heterogeneity of triple-negative breast cancer: Implications for therapy

This themed content collection focuses on recent advances in our understanding of the molecular and biological features of triple negative breast cancer and potential therapeutic strategies and novel approaches to targeted therapy.

Journal articles and book chapters

24-09-2018 | Breast cancer | Article

Progress in adjuvant systemic therapy for breast cancer

Pondé NF, Zardavas D, Piccart M. Nat Rev Clin Oncol 2018. doi:10.1038/s41571-018-0089-9

28-06-2018 | PARP inhibitors | Article

Synthetic lethal therapies for cancer: what’s next after PARP inhibitors?

Ashworth A. Lord CJ. Nat Rev Clin Oncol 2018. doi:10.1038/s41571-018-0055-6

27-06-2018 | Targeted therapy | Article

Selection of Optimal Adjuvant Chemotherapy and Targeted Therapy for Early Breast Cancer: ASCO Clinical Practice Guideline Focused Update

Denduluri N et al. J Clin Oncol 2018; JCO2018788604. doi:10.1200/JCO.2018.78.8604

04-06-2018 | Breast cancer | Article

BRCA1/2 testing: therapeutic implications for breast cancer management

Tung NM, Garber JE. Br J Cancer 2018. doi:10.1038/s41416-018-0127-5

Images and illustrations

12-04-2018 | Breast cancer | Images and illustration slides | Collection

Breast mammography

This downloadable powerpoint slide set comprises a collection of high quality images that depict the use of mammography in breast cancer screening and diagnosis. These slides can be used for reference purposes or for inclusion in one’s own slide sets. Slide notes are included where appropriate. Source: Bassett LW et al. Breast Imaging. In: Jatoi I, Kaufmann M, eds. Management of Breast Diseases. Springer Berlin Heidelberg.

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