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27-09-2017 | Image

Figure 3

Synthetic lethal (SL) interaction data from model organisms, such as data from TheCellMap or BioGRID, and tumour genomic sequence can be mined to discover new candidate SL interactions for validation in human cell lines, or direct SL interaction screening can be undertaken in human cell lines. Candidate SL interactions can be validated in genotypically defined cell line panels to determine whether SL interactions are conserved across cell lines or are limited to specific cell lines. RNAi, RNA interference