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27-09-2017 | Image

Figure 1

The loss or the inhibition of either of the protein products of gene A or B alone or the overexpression of gene A is viable (part a). Mutation (part b) or pharmacological inhibition (part c) of the protein product of gene B in cells with a mutation (parts b,c) or overexpression (part d) of gene A results in synthetic lethality. The thicker arrow denotes increased expression. The star shape denotes a mutation. The red crosses denote pharmacological inhibition. Viable cells are depicted as ovals, and inviable cells are depicted as random shapes.