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15-04-2018 | Breast cancer | Article

Immunotherapy in Breast Cancer: the New Frontier

Journal:
Current Breast Cancer Reports

Authors: Zishuo I. Hu, Heather L. McArthur

Publisher: Springer US

Abstract

This review summarizes current immunotherapies in breast cancer, with an emphasis on immune checkpoint inhibitors and vaccines.
Combination immunotherapy with checkpoint inhibitors and cytotoxic therapies have shown promising results. Active clinical trials are ongoing in both early stage and metastatic settings for triple negative, HER2+, and hormone-positive breast cancer patients.
Ongoing challenges remain in defining biomarkers that predict response to immunotherapy, determining the optimal combination immunotherapies, and enhancing the immunogenicity of breast cancer subtypes.

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