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04-04-2019 | TRK inhibitors | AACR 2019 | News

LOXO-195 could be an option for tumors resistant to first-generation TRK inhibitors

Early findings point to the antitumor efficacy of the next-generation TRK inhibitor LOXO-195 in patients with NTRK fusion-positive cancers and NTRK resistance mutations acquired during treatment with first-generation agents.

11-09-2017 | Soft-tissue sarcoma | Article

External Beam Radiation Therapy for Resectable Soft Tissue Sarcoma: A Systematic Review and Meta-Analysis

This meta-analysis of sixteen studies shows that the use of preoperative and postoperative external beam radiotherapy may reduce local recurrence of resectable soft tissue sarcomas.

Albertsmeier M et al. Ann Surg Oncol 2017. doi:org/10.1245/s10434-017-6081-2

27-07-2017 | Sarcoma | Article

Surgical treatment of pelvic sarcoma in children: outcomes for twenty six patients

This retrospective analysis of the medical records of young pelvic sarcoma patients shows that promising survival rate and functional outcomes can be obtained after reconstruction and amputation.

Kadhim M. Int Orthop 2017. doi:10.1007/s00264-017-3564-5

24-07-2017 | Soft-tissue sarcoma | Article

Neoadjuvant Radiotherapy is Associated with R0 Resection and Improved Survival for Patients with Extremity Soft Tissue Sarcoma Undergoing Surgery: A National Cancer Database Analysis

This retrospective analysis provides evidence that preoperative radiotherapy increases the likelihood of achieving an oncologically optimal resection in extremity soft tissue sarcoma patients.

Gingrich AA et al. Ann Surg Oncol 2017; 24: 3252-3263. doi:10.1245/s10434-017-6019-8

14-07-2017 | Sarcoma | Article

Complete response of mediastinal clear cell sarcoma to pembrolizumab with radiotherapy

This is the first report of a complete clinical response of recurrent, surgically incurable clear cell sarcoma in a young woman following pembrolizumab immune checkpoint blockade plus radiotherapy.

Marcrom et al. Clin Sarcoma Res 2017; 7: 14. doi:10.1186/s13569-017-0079-1

16-12-2016 | Sarcoma | Book chapter | Article


This chapter presents a summary of the natural history, diagnosis, pathology and treatment of liposarcoma.

Brennan MF et al. In: Management of Soft Tissue Sarcoma. Edited by Brennan MF, Antonescu CR, Alektiar KM, & Maki RG. Springer International Publishing, 2016. doi:10.1007/978-3-319-41906-0_5

26-10-2016 | Sarcoma | Article

Implications of lymph node evaluation in the management of resectable soft tissue sarcoma

In this study, Ecker et al. analyze a national cohort of patients with select high-risk sarcoma who underwent curative-intent resection and evaluated the relationship between regional lymph node identification and survival.

Ecker BL et al. Ann Surg Oncol 2017; 24: 425–433. doi:10.1245/s10434-016-5641-1

12-10-2016 | Sarcoma | Article

Soft tissue sarcoma of the extremities: pending questions on surgery and radiotherapy

Hoefkens et al. review the impact of the recent developments in the treatment of extremity soft tissue sarcomas.

Hoefkens F et al. Radiat Oncol 2016; 11: 136. doi:10.1186/s13014-016-0668-9

19-09-2016 | Sarcoma | Article

Sarcoma brain metastases: 28 years of experience at a single institution

In this retrospective study, Al Sannaa et al. examine their institutional experience with sarcomas metastatic to the brain, including histological subtypes, clinical presentation, pathological features, and clinical outcomes.

Al Sannaa G et al. Ann Surg Oncol 2016; 23(Suppl 5): 962–967. doi:10.1245/s10434-016-5559-7

22-04-2016 | Sarcoma | Book chapter | Article

Soft Tissue Sarcoma Brachytherapy

This chapter presents an overview of the use of brachytherapy as primary therapy or an adjunct to management of soft tissue sarcoma.

Fontanesi J et al. In: Brachytherapy. Edited by Montemaggi P, Trombetta M, & Brady LW. Springer International Publishing, 2016. doi:10.1007/978-3-319-26791-3_23

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