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10 search results for:

Vorinostat 

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"newest" sorts results by publication date. "most relevant" also considers factors like how often the search phrase is in the result.
  1. 13-08-2018 | FDA | News | Article
    approvalsWatch

    Mogamulizumab-kpkc approved for rare NHL subtypes

    Compared with use of vorinostat, patients using mogamulizumab-kpkc had significantly longer progression-free survival.

  2. 22-08-2018 | Non-Hodgkin lymphoma | News | Article

    Mogamulizumab improves cutaneous T-cell lymphoma outcomes

    MAVORIC trial results support the use of the C-C chemokine receptor 4-targeted antibody mogamulizumab over the standard of care vorinostat in previously treated patients with mycosis fungoides or Sézary syndrome.

    Published in:
    Lancet Oncol 2018; doi:10.1016/S1470-2045(18)30379-6 Lancet Oncol 2018; doi:10.1016/S1470-2045(18)30449-2
  3. 08-01-2019 | Cutaneous T-cell lymphoma | Brief review | Article

    Emerging therapies for cutaneous T-cell lymphoma

    The results from a pivotal phase III study showed that mogamulizumab reduced the risk of progression or death by 47% compared with vorinostat [17].

    Author:
    Dawn Queen, Adriana Lopez, Larisa J Geskin
  4. 09-03-2017 | Lymphoma | Case report | Article

    Cutaneous T-cell lymphoma

    Subsequent regimens included vorinostat and prednisone. 

    Author:
    Belen Rubio Gonzalez, Steven T Rosen, Christiane Querfeld
  5. 16-06-2017 | Breast cancer | Article

    A Phase I/II study of suberoylanilide hydroxamic acid (SAHA) in combination with trastuzumab (Herceptin) in patients with advanced metastatic and/or local chest wall recurrent HER2-amplified breast cancer: a trial of the ECOG-ACRIN Cancer Research Group (E1104)

    Goldstein LJ, Zhao F, Wang M et al. Breast Cancer Res Treat 2017; 165: 375-382. doi:10.1007/s10549-017-4310-9

  6. 12-08-2016 | Acute lymphoblastic leukemia | Article

    A review of new agents evaluated against pediatric acute lymphoblastic leukemia by the Pediatric Preclinical Testing Program

    The histone deacetylase inhibitor vorinostat was representative of clinical results, with no objective responses observed in either 8/8 ALL PDXs 48 or 6/6 pediatric leukemia patients in a Phase I trial. 104 Likewise, 2/2 ALL patients did not respond to vorinostat in an adult Phase I trial. 105 Similarly, the immunomodulatory agent lenalidomide showed no activity across the ALL PDX panel and had no clinical effect against adult ALL cases in a Phase I trial. 106 The stringency of PPTP testing criteria highlighted the broad lack of efficacy of kinase inhibitors as single agents.

    Author:
    L Jones, H Carol, K Evans, J Richmond, P J Houghton, M A Smith, R B Lock
  7. 14-10-2016 | Hematologic cancers | Article

    T-cell lymphomas, a challenging disease: types, treatments, and future

    Ma H & Abdul-Hay M. Int J Clin Oncol 2017; 22: 18–51. doi:10.1007/s10147-016-1045-2

  8. 01-12-2015 | Hematologic cancers | Article

    Molecular therapy for acute myeloid leukaemia

    In a phase II study 130 , the HDAC inhibitor vorinostat had minimal single-agent activity in patients with untreated or relapsed AML, leading to the initiation of combination studies this agent.

    Author:
    Catherine C. Coombs, Martin S. Tallman, Ross L. Levine
  9. 20-04-2016 | Multiple myeloma | Article

    Histone deacetylase inhibitors in multiple myeloma: from bench to bedside

    In this review, the authors discuss the underlying mechanisms of action of histone deacetylase inhibitors in multiple myeloma biology and analyze the future clinical implications for patients. Harada T, Hideshima T, & Anderson KC. Int J Hematol 2016; 104: 300–309. doi:10.1007/s12185-016-2008-0

  10. 03-02-2015 | Treatment | Article

    Treatment-related symptom management in patients with multiple myeloma: a review

    This review discusses current multiple myeloma treatment options, effective symptom management approaches, and practical strategies for supportive care. Colson K. Support Care Cancer 2015; 23: 1431–1445. doi:10.1007/s00520-014-2552-1

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