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Regorafenib 

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  1. 11-09-2017 | Glioblastoma multiforme | ESMO 2017 | Article
    ESMO 2017

    Regorafenib improves outcomes in relapsed glioblastoma patients

    The phase II REGOMA trial shows that patients with recurrent glioblastoma derive a significant overall survival and disease control benefit from treatment with regorafenib over lomustine.

  2. 03-05-2017 | Regorafenib | Drug approval | Article
    approvalsWatch

    Regorafenib approved for liver cancer, midostaurin for AML

    medwireNews : FDA approval for regorafenib has been expanded to include patients with hepatocellular carcinoma that has previously been treated with sorafenib.

  3. 01-04-2016 | Colorectal cancer | Article

    Is regorafenib providing clinically meaningful benefits to pretreated patients with metastatic colorectal cancer?

    García-Alfonso P et al. Clin Transl Oncol 2016; 18: 1072–1081. doi:10.1007/s12094-016-1499-8

  4. 23-05-2022 | Multitargeted kinase inhibitors | News | Article

    Oral retinoid may relieve multikinase inhibitor-related hand–foot skin reaction

    The most common multikinase inhibitor in the cohort was regorafenib, used in four patients, with cabozantinib, lenvatinib, sorafenib, and sunitinib used in one patient each.

  5. 15-03-2022 | Gastrointestinal stromal tumors | Adis Journal Club | Article
    Targeted Oncology

    The Management of Unresectable, Advanced Gastrointestinal Stromal Tumours

    Since then, as a result of several trials including the GRID and INVICTUS studies, we now have five lines of approved targeted therapy, including imatinib, sunitinib, regorafenib, ripretinib and avapritinib for the treatment of unresectable, advanced GISTs.

  6. 25-11-2020 | Tyrosine kinase inhibitors | News | Article

    Bleeding risk doubled during concurrent VEGFR–TKI, anticoagulant therapy

    The patients received one or more VEGFR–TKIs (pazopanib, sunitinib, sorafenib, axitinib, regorafenib, vandetanib, lenvatinib, or cabozantinib) and factor Xa inhibitors (low molecular weight heparin [LMWH] including enoxaparin or the direct oral anticoagulants [DOACs] rivaroxaban or apixaban) between 2010 and 2018 whilst undergoing treatment for a variety of cancers, including renal cell carcinoma (48.8%), sarcoma (23.3%), and colorectal cancer (11.6%).

  7. 02-03-2018 | Preclinical | News | Article

    Tumor organoids mirror metastatic GI cancer therapy responses

    And in mice that received PDO xenografts from a baseline biopsy of a patient who initially responded to regorafenib, treatment with the drug led to improved survival versus the vehicle control, but regorafenib did not confer such a benefit in animals xenografted with organoids derived from samples taken after the patient had progressed.

  8. 18-07-2017 | Colorectal cancer | Article

    Antiangiogenic tyrosine kinase inhibitors in colorectal cancer: is there a path to making them more effective?

    Karasic TB, Rosen MA and O’Dwyer PJ. Cancer Chemother Pharmacol . 2017. doi: 10.1007/s00280-017-3389-3

  9. 17-08-2017 | EMA | Drug approval | Article
    approvalsWatch

    Multiple orphan medications get nod from EMA

    . © 2017 Springer Healthcare part of the Springer Nature group See also: OS promise for 177Lu-dotatate in neuroendocrine tumors Avelumab given accelerated approval for metastatic Merkel cell carcinoma Midostaurin prolongs survival in FLT3-mutated AML Regorafenib approved for liver cancer, midostaurin for AML

  10. 06-12-2016 | Colorectal cancer | Article

    From tumour heterogeneity to advances in precision treatment of colorectal cancer

    For example, detection of mutations in circulating DNA can predict efficacy to regorafenib 94 , although no specific genetic variant was associated with drug activity.

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