Patients with locally advanced rectal cancer who receive total neoadjuvant therapy are more likely to adhere to chemotherapy and to experience a complete response than those treated with preoperative chemoradiation followed by postoperative adjuvant chemotherapy, according to the findings of a retrospective cohort analysis.

Research casts doubt on the benefit of robotic-assisted laparoscopic surgery for patients requiring rectal resection or radical nephrectomy, finding no significant benefits over a conventional laparoscopic approach.

Patients with rectal cancer undergoing laparoscopic rectal resection have a significantly higher risk for achieving a noncomplete mesorectal excision than do those undergoing open rectal resection, meta-analysis data show.

Patients are less likely to complete radiotherapy for rectal adenocarcinoma if treatment is performed at a different facility to their surgery, US study data show.

They were aged a median of 65 years and 60 had non-small-cell lung cancer (NSCLC), while 55 had colorectal cancer (CRC) and 22 had other solid tumors.

A pooled analysis of clinical trial data points to a link between obesity and an increased risk for any-grade immune-related adverse events among people receiving nivolumab monotherapy for advanced cancer.

The rates of population-based screening and diagnosis of breast, cervical, and colorectal cancer in the USA in 2021 remained below those reported before the COVID-19 pandemic, researchers caution in  JAMA Oncology .

Having type 2 diabetes increases a person’s risk for a cancer being already metastatic at the point of diagnosis, shows an EPIC analysis.

Treatment effects were modelled using data from the Prostate Testing for Cancer and Treatment (ProtecT) trial.

DOI [Teaser] Key Summary Points Colon cancer is one of the most common types of gastrointestinal cancer.

KRAS G12C mutations were detected in 3.7% of patients, most commonly in those with nonsquamous non-small-cell lung cancer (NSCLC) and NSCLC not otherwise subtyped, at rates of 7.5% and 6.9%, respectively, followed by cancer of unknown primary, colorectal cancer, and squamous NSCLC, at 4.1%, 3.5%, and 2.0%.

A systematic review and meta-analysis has identified global decreases in breast, cervical, and colorectal cancer screening during the early phase of the COVID-19 pandemic.

Because of its diagnostic, prognostic, and predictive value, liquid biopsy has been extensively studied also in metastatic colorectal cancer.

Researchers have used computer-based analyses to identify and confirm a large number genetic biomarkers that predict cancer treatment outcomes, as well as gene–gene interactions that may modify the effects of targeted treatments.

A small chart review points to the potential of acitretin for the treatment of refractory hand–foot skin reaction induced by multikinase inhibitors in people with cancer.

Author Jennifer Ligibel (Dana-Farber Cancer Institute, Boston, Massachusetts, USA) said in a comment to the press that “[t]his guidance lays to rest the common belief that patients should ‘rest’ during cancer treatment, suggesting instead that engaging in regular exercise during cancer treatment can help patients avoid toxicity and recover more quickly from cancer treatment.”

The study was conducted at seven UK hospitals and included 306 men at risk for prostate cancer on the basis of an elevated prostate-specific antigen level or abnormal digital rectal examination.