Patients with oligometastatic castration-resistant prostate cancer benefit from the addition of stereotactic body radiotherapy to first-line abiraterone acetate plus prednisone.

Akeega will be available in tablet form in fixed-dose combinations of niraparib 50 mg plus abiraterone 500 mg or niraparib 100 mg plus abiraterone 1000 mg, and should be given alongside prednisone or prednisolone. medwireNews is an independent medical news service provided by Springer Healthcare Ltd. © 2023 Springer Healthcare Ltd, part of the Springer Nature Group

The CHMP states that the PARP inhibitor should be given alongside abiraterone and prednisone or prednisolone to adults in whom chemotherapy is not clinically indicated.

Patients with a daily steroid dose greater than 10 mg prednisone daily equivalent and those with pulmonary comorbidities were also at greater risk for death in the month after infection than other individuals, as were men compared with women.

The active autologous dendritic cell-based immunotherapy DCVAC/PCa is well tolerated when combined with docetaxel plus prednisone but does not improve survival in men with metastatic castration-resistant prostate cancer, phase 3 study data show.

Men with metastatic castration-resistant prostate cancer harboring homologous recombination repair gene alterations could benefit from the addition of niraparib to first-line abiraterone acetate plus prednisone, suggest phase 3 trial data.

Fred Saad video In the double-blind PROpel trial, 796 men with ongoing androgen deprivation therapy were randomly assigned to receive first-line treatment with either olaparib 300 mg twice a day or matching placebo alongside abiraterone 1000 mg/day plus prednisone or prednisolone 5 mg twice daily.

The study included 245 men with mCRPC carrying mutations in the homologous recombination repair (HRR) genes BRCA1 , BRCA2 , and ATM who were randomly assigned to receive olaparib 300 mg twice daily (n=162) or a physician’s choice of either enzalutamide 160 mg/day or abiraterone 1000 mg/day plus prednisone 5 mg twice daily (n=83).

The addition of bone resorption inhibitors to abiraterone acetate plus prednisone is associated with improved survival outcomes in patients with metastatic castration-resistant prostate cancer and bone metastases, especially if they have high-volume disease, researchers report.

He explained that the phase 3 study, which has a 2x2 factorial design, is evaluating the efficacy and safety of adding abiraterone acetate plus prednisone and/or local radiotherapy to standard of care (SOC) in the mCSPC setting.

“Docetaxel plus prednisone, with or without pembrolizumab, will be evaluated in a similar population of patients in the ongoing, randomized, phase 3 KEYNOTE-921 trial.”

In the trial, 982 men with ongoing androgen deprivation therapy, but no other prior treatment for mCRPC, were randomly assigned to receive abiraterone acetate 1000 mg/day plus prednisone 5 mg twice daily either with or without apalutamide 240 mg/day.

Christopher Sweeney_200920 Indeed, the co-primary endpoint of radiographic PFS in the PTEN-loss group was significantly prolonged for the 260 patients who were randomly assigned to receive ipatasertib 400 mg/day alongside abiraterone 1000 mg/day plus prednisone 5 mg twice daily relative to their 261 counterparts who instead received placebo and abiraterone plus prednisone, at a median of 18.5 and 16.5 months, respectively.

This was statistically and clinically significantly longer than the median of 3.55 months achieved by the 83 men who were instead given physician’s choice of either enzalutamide 160 mg/day or abiraterone 1000 mg/day plus prednisone 5 mg twice daily, and translated into a 66% reduced risk for progression or death, said Hussain.

The study, published in the Annals of Oncology , included 547 patients from two prospective cohorts who were treated with abiraterone 1000 mg/day plus prednisone 10 mg/day or enzalutamide 160 mg/day.

The safety profile of nivolumab plus ipilimumab was “manageable,” the presenter said, noting that 13% of patients were given prednisone at a dose of 40 mg/day or more for immune-mediated events.

A sequencing strategy that uses abiraterone acetate plus prednisone followed by enzalutamide, rather than the opposite, provides the greatest clinical benefit to patients with newly diagnosed metastatic castration-resistant prostate cancer, researchers report.

Both cabazitaxel formulations are for use alongside prednisone or prednisolone. medwireNews is an independent medical news service provided by Springer Healthcare. © 2020 Springer Healthcare part of the Springer Nature Group

A phase 1/2 clinical trial showed that DCVAC/PCa combined with docetaxel chemotherapy and prednisone  in patients with mCRPC was safe, and resulted in longer than expected survival.