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8 search results for:

Panobinostat 

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  1. 27-09-2016 | Multiple myeloma | Article

    The Role of Panobinostat Plus Bortezomib and Dexamethasone in Treating Relapsed or Relapsed and Refractory Multiple Myeloma: A European Perspective

    An expert review of current treatment options for relapsed/refractory multiple myeloma, the mechanism of action of panobinostat, and how panobinostat fits into the current therapeutic landscape. San-Miguel JF, Einsele H, & Moreau P. Adv Ther 2016; 33: 1896–1920. doi:10.1007/s12325-016-0413-7

  2. 16-02-2017 | Multiple myeloma | Article

    Immunomodulatory drugs in multiple myeloma: mechanisms of action and clinical experience

    This articles reviews the clinical efficacy of immunomodulatory drugs, their structure-function relationship, molecular mechanisms of action, and associated second primary malignancies and thrombosis. Holstein SA & McCarthy PL. Drugs 2017; 77: 505–520. doi:10.1007/s40265-017-0689-1

  3. 10-01-2017 | Multiple myeloma | Article

    Multiple myeloma in 2016: Fresh perspectives on treatment and moments of clarity

    A comprehensive overview of the latest updates in 2016 and a prospective look towards the therapeutic landscape in 2017 for patients with multiple myeloma.  Nat Rev Clin Oncol 2017; 14: 73–74. doi:10.1038/nrclinonc.2016.221

    Author:
    Prashant Kapoor, S. Vincent Rajkumar
  4. 04-01-2016 | Treatment | Article

    Evolving paradigms in the treatment of relapsed/refractory multiple myeloma: increased options and increased complexity

    Panobinostat was recently approved by the US Food and Drug Administration for the treatment of relapsed MM patients who had received ≥2 prior regimens, including bortezomib and an IMiD.

    Author:
    R F Cornell, A A Kassim
  5. 30-06-2016 | Multiple myeloma | Article

    Novel agents in the treatment of multiple myeloma: a review about the future

    The authors review the plethora of novel agents currently in development or recently approved for the treatment of patients with multiple myeloma. Naymagon L & Abdul-Hay M. J Hematol Oncol 2016; 9: 52. doi:10.1186/s13045-016-0282-1

  6. 20-04-2016 | Multiple myeloma | Article

    Histone deacetylase inhibitors in multiple myeloma: from bench to bedside

    In this review, the authors discuss the underlying mechanisms of action of histone deacetylase inhibitors in multiple myeloma biology and analyze the future clinical implications for patients. Harada T, Hideshima T, & Anderson KC. Int J Hematol 2016; 104: 300–309. doi:10.1007/s12185-016-2008-0

  7. 01-12-2015 | Hematologic cancers | Article

    Molecular therapy for acute myeloid leukaemia

    Panobinostat, a pan-HDAC inhibitor, has also been combined with azacitidine in a phase Ib/II study involving patients with AML and high-risk MDS 136 , the results of which demonstrated a 31% ORR (CR, CRi, and PR) in the subgroup of patie

    Author:
    Catherine C. Coombs, Martin S. Tallman, Ross L. Levine
  8. 03-02-2015 | Treatment | Article

    Treatment-related symptom management in patients with multiple myeloma: a review

    This review discusses current multiple myeloma treatment options, effective symptom management approaches, and practical strategies for supportive care. Colson K. Support Care Cancer 2015; 23: 1431–1445. doi:10.1007/s00520-014-2552-1

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