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166 search results for:

Metastasis 

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  1. 10-08-2022 | Cutaneous squamous cell carcinoma | Adis Journal Club | Article
    Advances in Therapy

    Identification of Metastasis-Associated Genes in Cutaneous Squamous Cell Carcinoma Based on Bioinformatics Analysis and Experimental Validation

    Once metastasis occurs, it will lead to poor prognosis and even death.

  2. 25-04-2022 | Metastasis | Adis Journal Club | Article
    Oncology and Therapy

    The Effect of Irisin on Proliferation, Apoptosis, and Expression of Metastasis Markers in Prostate Cancer Cell Lines

    The matrix metalloproteinases (MMPs) are a family of proteolytic enzymes involved in facilitating cancer metastasis.

  3. 26-10-2023 | Toxicities | Teaser

    Looking for coverage of ESMO 2023?

    There's a new home for news and congress coverage! Catch up on all the top stories and latest evidence in oncology research with our ESMO congress hub page.  Learn more »

  4. 20-10-2023 | Prostate cancer | News | Article

    Enzalutamide use supported for biochemically recurrent prostate cancer

    The researchers report in The New England Journal of Medicine that outcomes such as metastasis-free survival (MFS), time to prostate-specific antigen (PSA) progression, and time to first use of antineoplastic therapy were significantly improved with the androgen receptor inhibitor.

  5. 14-11-2019 | Castration-sensitive prostate cancer | News | Article

    No delay in progressive CSPC metastasis with PAP-targeted vaccine

    Phase II study data suggest that the prostatic acid phosphatase-encoding pTVG-HP vaccine does not improve metastasis-free survival in men with progressive, nonmetastatic, castration-sensitive prostate cancer.

  6. 14-02-2020 | ASCO GU 2020 | News | Article

    ​​​​​​​STOMP 5-year results confirm potential of metastasis-directed therapy in prostate cancer

    Metastasis-directed therapy for oligometastatic recurrent prostate cancer continues to be associated with better androgen deprivation therapy-free survival relative to surveillance at 5 years, show follow-up findings from the STOMP trial.

  7. 18-02-2019 | Castration-resistant prostate cancer | News | Article
    ASCO GU 2019

    Darolutamide reduces CRPC metastasis risk

    Addition of the androgen receptor antagonist darolutamide to androgen deprivation therapy improves metastasis-free survival in patients with castration-resistant prostate cancer, indicate ARAMIS trial results.

  8. 24-05-2019 | Small-cell lung cancer | News | Article

    Twice-daily radiotherapy may increase brain metastasis risk in SCLC

    Marginal survival gains among patients with small-cell lung cancer who receive twice- versus once-daily thoracic radiotherapy plus prophylactic cranial irradiation occur at the cost of an increased risk for brain metastases, research shows.

  9. 23-02-2018 | Prostate cancer | News | Article

    Androgen receptor inhibition delays CRPC metastasis

    The results of two independent trials presented at the 2018 ASCO Genitourinary Cancers Symposium suggest that the use of an androgen receptor inhibitor alongside androgen deprivation therapy can delay metastasis in men with castration-resistant prostate cancer.

  10. 12-04-2018 | Prostate cancer | Article

    Apalutamide Treatment and Metastasis-free Survival in Prostate Cancer

    Smith MR et al. N Eng J Med 2018; 378: 1408-1418. doi:10.1056/NEJMoa1715546

  11. 04-08-2017 | CNS metastases | Article

    Molecular characterization of breast cancer CTCs associated with brain metastasis

    The authors propose circulating tumor cell biomarkers and signaling pathways implicated in breast cancer brain metastasis that may be used as a screening tool or for making rational treatment decisions and monitoring therapeutic response. Boral D, Vishnoi M, Liu HN et al.  Nat Commun 2017;8:196. doi:10.1038/s41467-017-00196-1

  12. 06-09-2017 | CNS metastases | Article

    RNAi screen identifies essential regulators of human brain metastasis-initiating cells

    The authors develop a useful preclinical model of brain metastases and present potential therapeutic targets that block the metastatic process, transforming the disease into a locally controlled and more treatable one. Singh M, Venugopal C, Tokar T et al. Acta Neuropathol 2017. doi:10.1007/s00401-017-1757-z

  13. 20-04-2023 | Urothelial cancer | At a glance | Article

    At a glance: Second and later line immunotherapy for advanced urothelial carcinoma

    A summary of the key trial publications on the use of PD-1 pathway and CTLA-4 inhibitors alone or in combination in the second-line or later treatment of locally advanced and metastatic urothelial carcinoma. This independent article was supported by an educational grant from Pfizer and Merck Healthcare KGaA, Darmstadt, Germany

  14. 15-01-2018 | Colorectal cancer | Article

    Surgical stress response and promotion of metastasis in colorectal cancer: a complex and heterogeneous process

    Behrenbruch C et al.  Clin Exp Metastasis . 2018. doi:10.1007/s10585-018-9873-2

  15. 08-08-2017 | Melanoma | Article

    Tumour mutation status and sites of metastasis in patients with cutaneous melanoma

    Adler et al. examine whether BRAF and NRAS mutant tumors exhibit an increased propensity to metastasize to specific organs in cutaneous melanoma patients to determine whether these genes can be used to direct metastatic surveillance. British Journal of Cancer  2017; 117, 1026–1035. doi:10.1038/bjc.2017.254

  16. 21-09-2017 | Neuroendocrine tumors | Article

    Early recurrence of neuroendocrine liver metastasis after curative hepatectomy: risk factors, prognosis, and treatment

    The objective of this retrospective study was to investigate the risk factors, treatment, and prognosis of early recurrence of neuroendocrine tumor liver metastasis (NELM) after hepatic resection. Zhang XF, Beal EW, Chakedis J et al. J Gastrointest Surg . 2017. https://doi.org/10.1007/s11605-017-3490-2

  17. 07-03-2017 | CNS metastases | Article

    Comparing available criteria for measuring brain metastasis response to immunotherapy

    Here we report a comparison between available response criteria when used to evaluate CNS response of patients from a Phase II trial studying the effect of pembrolizumab in patients with previously untreated or progressive melanoma or lung cancer brain metastases. Qian JM et al. J Neurooncol 2017. doi:10.1007/s11060-017-2398-8

  18. 29-03-2023 | Prostate cancer | News | Article

    ProtecT 15-year results: Prostate cancer-specific mortality ‘low’ irrespective of treatment

    “Radical treatments (prostatectomy or radiotherapy) reduced the incidence of metastasis, local progression, and long-term androgen-deprivation therapy by half as compared with active monitoring,” note the researchers in The New England Journal of Medicine.

  19. 18-10-2016 | Prostate cancer | News | Article

    Metastasis-free survival, PTEN loss explored in prostate cancer

    Proffered paper presentations on prostate cancer at the ESMO 2016 Congress, held in Copenhagen, Denmark, covered metastasis-free survival as a surrogate for overall survival in localised disease, and PTEN loss as a predictive biomarker for ipatasertib plus abiraterone therapy in metastatic castration-resistant prostate cancer.

  20. 21-02-2017 | Melanoma | Article

    The impact of smoking on sentinel node metastasis of primary cutaneous melanoma

    Jones MS et al.  Ann Surg Oncol  2017; 24: 2089. doi:10.1245/s10434-017-5775-9

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