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Leukemia 

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  1. 31-01-2022 | Chronic myeloid leukemia | Adis Journal Club | Article
    Advances in Therapy

    Chronic Myeloid Leukemia Data at ASH 2021: A Podcast on Patient Unmet Needs and Later-Line Treatment Developments

  2. 31-05-2023 | Cardiotoxicity | News | Article

    Anthracyclines may increase heart failure risk among YA cancer survivors

    Of note, the 5-year cumulative rate of heart failure was highest among people with a diagnosis of leukemia, but the researchers point out that heart failure incidence was also significantly higher among people with kidney, bone, and breast cancer and lymphoma – tumors commonly treated with anthracycline-based therapy – than other cancer types.

  3. 08-12-2018 | Pain | Article

    Pain in patients with newly diagnosed or relapsed acute leukemia

    Shaulov A et al. Support Care Cancer 2019; 27: 2789. doi:10.1007/s00520-018-4583-5

  4. 20-09-2018 | FDA | News | Article
    approvalsWatch

    Hairy cell leukemia cytotoxin therapy approved by FDA

    The approval follows results of Study 1053 of 80 pretreated classic hairy cell leukemia or hairy cell leukemia variant patients where a durable complete response was achieved by 30% Moxetumomab pasudotox-tdfk is recommended to be given over a 30-minute infusion at a dose of 0.04 mg/kg on days 1, 3, and 5 of each 28-day cycle.

  5. 12-09-2018 | Pediatric leukemia | News | Article

    Levofloxacin reduces bacteremia during chemotherapy for childhood leukemia

    Levofloxacin prophylaxis significantly reduces the risk for bacteremia among children receiving intensive chemotherapy for acute leukemia, but not among those undergoing hematopoietic stem cell transplantation, study data show.

  6. 24-08-2018 | Chronic lymphocytic leukemia | News | Article

    Obinutuzumab plus venetoclax shows promise for chronic lymphocytic leukemia

    Obinutuzumab and venetoclax, preceded by bendamustine debulking for high tumor loads, shows high response rates without unexpected or cumulative toxicities in patients with chronic lymphocytic leukemia, a phase II trial suggests.

  7. 05-05-2023 | Breast cancer | News | Article

    DESTINY-Breast02 supports T-DXd as ‘preferred’ regimen after progression on T-DM1

    And there were four fatal drug-related TEAEs in the T-DXd group – two cases of pneumonitis and one each of acute myeloid leukemia and pneumonia – versus none in the control group.

  8. 11-09-2018 | Pediatric leukemia | News | Article

    Maternal hormonal contraceptive use linked to childhood non-lymphoid leukemia risk

    The use of hormonal contraceptives just before and during pregnancy may significantly increase the risk for childhood non-lymphoid leukemia, Danish researchers report.

  9. 02-02-2018 | Chronic myeloid leukemia | Editorial | Article

    Discontinuing tyrosine kinase inhibitors in chronic myeloid leukemia

    Tyrosine kinase inhibitor (TKI) treatment of chronic myeloid leukemia (CML) can result in prolonged and deep responses in many patients. In such cases, can TKIs be safely discontinued to avoid adverse side effects and costs? Etab Atallah (Medical College of Wisconsin, USA) discusses the current issues surrounding TKI discontinuation in CML.

  10. 02-02-2018 | Chronic myeloid leukemia | Highlight | Teaser
    Expert opinion

    Discontinuing tyrosine kinase inhibitors in chronic myeloid leukemia

    Tyrosine kinase inhibitor (TKI) treatment of chronic myeloid leukemia (CML) can result in prolonged and deep responses in many patients. In such cases, can TKIs be safely discontinued to avoid adverse side effects and costs? Etab Atallah (Medical College of Wisconsin, USA) discusses the current issues surrounding TKI discontinuation in CML.

  11. 24-01-2018 | Leukemia | News | Article

    Venetoclax, inotuzumab ozogamicin promising in older leukemia patients

    Two trials reported in The Lancet Oncology point to novel, first-line treatment options for older patients with acute myeloid leukemia and those with acute lymphoblastic leukemia. Read the linked commentary by Xavier Thomas.

  12. 25-10-2017 | Acute leukemia | Article

    (Immuno)proteasomes as therapeutic target in acute leukemia

    The authors summarize the positioning of bortezomib, a first-generation proteasome inhibitor, and second-generation proteasome inhibitors in leukemia treatment from a preclinical and clinical perspective. Cloos J, Roeten MS, Franke NE et al. Cancer Metastasis Rev 2017. doi:10.1007/s10555-017-9699-4

  13. 15-11-2017 | Leukemia | Article

    Agents in Development for Childhood Acute Lymphoblastic Leukemia

    Maloney KW & Gore L. Pediatr Drugs 2017. doi:10.1007/s40272-017-0268-7

  14. 13-09-2017 | Pediatric leukemia | Article

    Genetic susceptibility in childhood acute lymphoblastic leukemia

    The authors review the most important findings regarding genetic susceptibility to childhood acute lymphoblastic leukemia (ALL), specifically the major subtype B-cell precursor ALL, and point to new findings with important implications. Gutierrez-Camino A et al. Med Oncol 2017; 34: 179. doi:10.1007/s12032-017-1038-7

  15. 24-10-2017 | Acute myeloid leukemia | Article

    Measurement of residual disease in acute myeloid leukemia

    Vedula RS & Lindsley RC. Curr Hematol Malig Rep  2017. doi:10.1007/s11899-017-0428-4

  16. 05-12-2017 | Leukemia | Article

    Pharmacokinetics of recombinant asparaginase in children with acute lymphoblastic leukemia

    Völler G, Pichlmeier U, Zens A & Hempel G. Cancer Chemother Pharmacol 2017. doi:10.1007/s00280-017-3492-5

  17. 12-01-2018 | Acute myeloid leukemia | Article

    Impact of antithymocyte globulin doses in reduced intensity conditioning before allogeneic transplantation from matched sibling donor for patients with acute myeloid leukemia: a report from the acute leukemia working party of European group of Bone Marrow Transplantation

    Devillier R et al. Bone Marrow Transplant  2018; doi:10.1038/s41409-017-0043-y

  18. 18-12-2017 | Acute myeloid leukemia | Article

    Chromothripsis in acute myeloid leukemia: Biological features and impact on survival

    Fontana M et al.  Leukemia 2017; doi:10.1038/leu.2017.351

  19. 28-07-2017 | Chronic lymphocytic leukemia | Article

    Targeting B Cell Signaling in Chronic Lymphocytic Leukemia

    The authors provide an overview of recent work on developing therapies targeting the B cell receptor signaling pathway in chronic lymphocytic leukemia and highlight future avenues for development. Arnason JE, Brown JR. Curr Oncol Rep 2017; 19: 61. doi:10.1007/s11912-017-0620-7

  20. 25-07-2017 | Acute myeloid leukemia | Article

    Recent developments in immunotherapy of acute myeloid leukemia

    This review surveys the current most prominent concepts in the immunotherapy of acute myeloid leukemia as well as the considerable progress made over the past few years. Lichtenegger FS et al. J Hematol Oncol 2017; 10: 142. doi:10.1186/s13045-017-0505-0

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