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Hypomethylating agents 

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  1. 24-01-2018 | Leukemia | News | Article

    Venetoclax, inotuzumab ozogamicin promising in older leukemia patients

    One study investigated the addition of the BCL-2 inhibitor venetoclax to hypomethylating agents in AML patients aged 65 years and older, while the other evaluated the combination of inotuzumab ozogamicin – an anti-CD22 antibody bound to the cytotoxic agent calicheamicin – and low-intensity chemotherapy in ALL patients aged at least 60 years.

  2. 14-03-2018 | Article

    Advisory board comment

    Hypomethylating agents (HMAs) currently represent the standard of care for the treatment of elderly AML patients unfit for intensive chemotherapy.

  3. 07-09-2017 | Acute myeloid leukemia | News | Article

    Guadecitabine benefits older patients with untreated AML

    Older patients with untreated acute myeloid leukemia respond well to the next-generation hypomethylating drug guadecitabine, with more than half achieving a composite complete response in a phase II trial of different drug doses and schedules.

  4. 14-03-2017 | Leukemia | Editorial | Article

    FMS-like tyrosine kinase 3 (FLT3)-inhibition in FLT3 mutated acute myeloid leukemia: A promising approach

    Sorafenib has also shown promising efficacy in combination with hypomethylating agents (azacitidine) [14], low-dose homoharringtonine [15], or low-dose cytarabine [16] in primary refractory FLT3 -ITD + AML.

  5. 01-12-2015 | Hematologic cancers | Article

    Molecular therapy for acute myeloid leukaemia

    These agents were among the first targeted agents to be added to standard induction chemotherapy for patients with AML, and current evidence for this approach will be briefly discussed in the following paragraph.

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