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3 search results for:

Duvelisib 

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  1. 17-10-2018 | Chronic lymphocytic leukemia | News | Article

    Duvelisib offers treatment alternative for patients with CLL/SLL

    The oral, dual inhibitor of phosphoinositide 3-kinase-δ and –γ duvelisib significantly delays disease progression or death compared with ofatumumab in patients with relapsed or refractory chronic lymphocytic leukemia or small lymphocytic lymphoma, data from the DUO trial show.

    Published in:
    Blood 2018; doi:10.1182/blood-2018-05-850461
  2. 02-03-2018 | Hematologic cancers | News | Article

    Next-generation PI3Kδ inhibitor umbralisib warrants further investigation

    Owen O’Connor (Columbia University Medical Center, New York, USA) and colleagues explain that umbralisib is structurally distinct from other PI3Kδ inhibitors, such as idelalisib and duvelisib, with improved isoform selectivity, minimal off-target cytochrome P450 inhibition, and a plasma exposure concentration that makes it suitable for once-daily dosing.

    Published in:
    Lancet Oncol 2018; Advance online publication
  3. 29-12-2016 | Lymphoma | Article

    The landscape of new drugs in lymphoma

    In this review, Younes et al describe the most promising agents in clinical development for the treatment of lymphoma and provide expert opinion on new strategies that may streamline drug development. Nat Rev Clin Oncol  2017; 14: 335–346. doi:10.1038/nrclinonc.2016.205

    Author:
    Anas Younes, Stephen Ansell, Nathan Fowler, Wyndham Wilson, Sven de Vos, John Seymour, Ranjana Advani, Andres Forero, Frank Morschhauser, Marie Jose Kersten, Kensei Tobinai, Pier Luigi Zinzani, Emanuele Zucca, Jeremy Abramson, Julie Vose
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