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Chemoprevention 

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  1. 06-11-2018 | Chemoprevention | News | Article
    NCRI 2018

    Run-in period may improve adherence to aspirin for chemoprevention

    In patients undergoing radical therapy for cancer, an 8-week run-in period of aspirin is acceptable and well tolerated, and could reduce the risk for nonadherence and participant attrition in adjuvant and prevention trials, say researchers.

  2. 26-06-2018 | Chemoprevention | ASCO 2018 | Article
    News in brief

    Chemoprevention with high-dose PPIs, aspirin an option for Barrett’s esophagus patients

    Treatment with high-dose proton pump inhibitors and aspirin, especially when taken together, could prevent the progression of Barrett’s esophagus, trial results suggest.

  3. 05-01-2018 | Non-melanoma skin cancer | News | Article

    Topical fluorouracil may have role in cutaneous SCC chemoprevention

    They add: “Topical fluorouracil is the first agent we know of that demonstrates extended posttreatment effects in SCC chemoprevention.”

  4. 15-12-2016 | Colorectal cancer | News | Article
    News in brief

    Advanced colorectal neoplasia chemoprevention strategies assessed

    A network meta-analysis in The BMJ ranks colorectal neoplasia chemoprevention agents in terms of efficacy and safety, finding that non-aspirin NSAIDs

  5. 24-09-2016 | Skin cancers | Article

    Primary and secondary chemoprevention of malignant melanoma

    Mounessa J et al. Am J Clin Dermatol 2016;17:625–634. doi:10.1007/s40257-016-0221-5

  6. 12-02-2016 | Epidemiology | Article

    Aspirin and colorectal cancer: the promise of precision chemoprevention

    Figure 1: Timeline of notable human studies in aspirin chemoprevention.

  7. 21-06-2022 | Dietary supplementation | News | Article

    USPSTF continues to recommend against supplement use to prevent cancer, CVD in latest update

    The USPSTF continues to recommend against the use of beta carotene and vitamin E for the primary prevention of cancer or cardiovascular disease in its updated 2022 recommendations, and maintains that the evidence is insufficient to assess the benefit–risk balance for the use of single- or paired-nutrient and multivitamin supplements.

  8. 07-11-2019 | Prostate cancer | News | Article

    Detection bias may contribute to reduced prostate cancer risk in diabetes

    In an accompanying comment, Kyla Velaer and John Leppert, both from Stanford University Medical School in California, USA, say that the study “questions the role of diabetes medications in the chemoprevention of prostate cancer.”

  9. 04-11-2019 | Prostate cancer | News | Article

    Factors mediating statin prostate cancer protective effect identified

    Statin use is associated with a reduced risk for low- and high-Gleason score prostate cancer, but the association is modified by the duration, dose, and type of statin, study results suggest.

  10. 14-03-2019 | Aspirin | News | Article

    Aspirin does not improve prostate cancer-specific survival, but may reduce lung cancer incidence

    . © 2019 Springer Healthcare part of the Springer Nature group See also: Aspirin, NSAID use may reduce ovarian cancer-specific mortality Chemoprevention with high-dose PPIs, aspirin an option for Barrett’s esophagus patients Run-in period may improve adherence to aspirin for chemoprevention

  11. play
    06-06-2018 | Esophageal cancer | ASCO 2018 | Video

    Researcher comment: Shedding light on the use of PPIs and aspirin in patients with Barrett’s esophagus

    Janusz Jankowski discusses his team's findings from the AspECT study on the chemoprevention efficacy and safety of aspirin and esomeprazole in esophageal cancer (7:42). 

  12. 11-01-2019 | Chemoprevention | News | Article
    News in brief

    COMT gene modifies chemopreventive effects of vitamin E

    Vitamin E supplementation may reduce the risk for cancer but only in individuals harboring a particular allele of the catechol-O-methyltransferase gene, suggests an analysis of two randomized trials.

  13. 07-09-2017 | Gastrointestinal cancers | Article

    New use of low-dose aspirin and risk of colorectal cancer by stage at diagnosis: a nested case–control study in UK general practice

    García Rodríguez LA, Soriano-Gabarró M, Bromley S, Lanas A & Cea Soriano L. BMC Cancer 2017; 17: 637. doi:10.1186/s12885-017-3594-9

  14. 17-06-2017 | Breast cancer | Article

    Preferences for breast cancer risk reduction among BRCA1/BRCA2 mutation carriers: a discrete-choice experiment

    Liede A, Mansfield CA, Metcalfe KA, Price MA. Breast Cancer Res Treat 2017; 165: 433-444. doi:10.1007/s10549-017-4332-3

  15. 13-12-2016 | Ovarian cancer | Article

    Delivering widespread BRCA testing and PARP inhibition to patients with ovarian cancer

    In doing so, this approach offers a rare opportunity to prevent others from developing cancer, by implementing risk-reducing strategies, such as prophylactic surgery, appropriate screening or chemoprevention.

  16. 13-12-2016 | PARP inhibitors | Article

    Delivering widespread BRCA testing and PARP inhibition to patients with ovarian cancer

    In doing so, this approach offers a rare opportunity to prevent others from developing cancer, by implementing risk-reducing strategies, such as prophylactic surgery, appropriate screening or chemoprevention.

  17. 27-01-2015 | Breast cancer | Article

    Current management of lesions associated with an increased risk of breast cancer

    Chemoprevention The observation that women with invasive breast cancer who received adjuvant tamoxifen had a substantial reduction in the incidence of contralateral cancers 73  led to studies of tamoxifen therapy for chemoprevention in women at increased risk of breast cancer development.

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