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Brain metastases 

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  1. 20-06-2022 | Non-small-cell lung cancer | News | Article

    Lorlatinib benefits extend to NSCLC patients with brain metastases

    Patients with advanced ALK- positive non-small-cell lung cancer derive prolonged progression-free survival from first-line treatment with lorlatinib regardless of the presence of brain metastases, post-hoc analyses indicate.

  2. 24-05-2022 | Breast cancer | News | Article
    News in brief

    No benefit of etirinotecan pegol for breast cancer patients with brain metastases

    Etirinotecan pegol does not improve the overall survival of people with breast cancer and stable brain metastases relative to physicians’ choice of single-agent chemotherapy, show trial data.

  3. 03-05-2022 | Non-small-cell lung cancer | News | Article

    ICIs plus radiotherapy promising for patients with resected NSCLC brain metastases

    Individuals with non-small-cell lung cancer and brain metastases may benefit from treatment with immune checkpoint inhibitors plus radiotherapy after neurosurgical resection, findings indicate.

  4. 21-10-2021 | Renal cell carcinoma | News | Article

    Cabozantinib shows activity against RCC brain metastases

    Cabozantinib has “considerable” intracranial activity in patients with advanced renal cell carcinoma and brain metastases, say the authors of a chart review published in JAMA Oncology .

  5. 13-09-2021 | WCLC 2021 | Conference coverage | Article

    Atezolizumab plus chemotherapy feasible for NSCLC with brain metastases

    Treatment with carboplatin and pemetrexed plus atezolizumab shows promise for people with nonsquamous non-small-cell lung cancer and asymptomatic, untreated brain metastases, phase 2 study findings indicate.

  6. 03-10-2019 | Non-small-cell lung cancer | Video | Article

    Expert comment: Brain metastases in lung cancer

    Lizza Hendriks provides insight into two studies focusing on brain metastases in patients with non-small-cell lung cancer, the ASCEND-7 trial of ceritinib and an analysis of the genomic and epigenomic landscape of the metastases (4:26).

  7. 26-03-2019 | CNS metastases | News | Article

    Pachymeningeal seeding possible after brain metastases resection

    Neurosurgical resection of brain metastases followed by stereotactic radiation can lead to pachymeningeal seeding outside of the stereotactic radiation field, according to findings reported in JAMA Oncology .

  8. 26-06-2020 | Small-cell lung cancer | News | Article

    First-line stereotactic radiosurgery an option for brain metastases in SCLC

    Patients with small-cell lung cancer and brain metastases may benefit from first-line treatment with stereotactic radiosurgery, suggest findings from the FIRE-SCLC study.

  9. 14-07-2020 | Breast cancer | News | Article

    KAMILLA findings support T-DM1 for HER2-positive breast cancer brain metastases

    Exploratory analyses from the KAMILLA trial indicate that trastuzumab emtansine may be a feasible option for HER2-positive breast cancer patients who have brain metastases.

  10. 18-06-2019 | Video

    Brain metastases treatment

  11. 17-07-2018 | Melanoma | Teaser
    medwireNews

    ‘Dramatically improved’ OS with checkpoint inhibitor use for melanoma brain metastases

    Melanoma patients with brain metastases can expect to live longer following the incorporation of checkpoint inhibitors and BRAF -targeted therapies into standard care than their counterparts treated prior to the approval of these agents, suggests an analysis of the US National Cancer Database.

  12. 26-06-2019 | Renal cell carcinoma | News | Article
    News in brief

    Nivolumab has ‘limited’ CNS activity in RCC patients with brain metastases

    In patients with clear cell renal cell carcinoma and untreated central nervous system metastases, intracranial response to nivolumab monotherapy is restricted to those with a limited tumor burden, suggest phase II findings.

  13. 05-09-2019 | Testicular cancer | News | Article

    Brain metastases linked to poor survival in men with testicular germ cell tumors

    Among men with testicular germ cell tumors, those with more than one extrapulmonary metastasis – particularly brain metastases – have the poorest survival, according to an analysis of data the US SEER database.

  14. 28-07-2018 | CNS metastases | Article

    Prognostic Classification Systems for Brain Metastases

    Sperduto PW. In: Adult CNS Radiation Oncology. Edited by Chang EL, Brown PD, Lo SS, Sahgal A, Suh JH. Springer International Publishing AG 2018. doi:10.1007/978-3-319-42878-9

  15. 22-08-2017 | CNS metastases | Article

    Survival and level of care among breast cancer patients with brain metastases treated with whole brain radiotherapy

    Frisk G, et al. Breast Cancer Res Treat 2017. doi:10.1007/s10549-017-4466-3

  16. 17-08-2017 | Melanoma | Article

    Metastatic melanoma: prognostic factors and survival in patients with brain metastases

    This retrospective study assesses the viability of the melanoma-specific graded prognostic assessment in modern populations, with the aim of determining the efficacy of stereotactic radiosurgery combined with other systemic therapies versus whole-brain radiotherapy. Frinton E et al.  J Neurooncol 2017. doi:10.1007/s11060-017-2591-9

  17. 27-03-2017 | Breast cancer | News | Article

    Brain metastases in newly diagnosed breast cancer patients profiled

    Patients with hormone receptor-negative/human epidermal growth factor receptor 2-positive breast cancer have the highest incidence of brain metastases at diagnosis, followed by those with triple-negative disease, population-based study data show.

  18. 17-07-2018 | Melanoma | News | Article

    ‘Dramatically improved’ OS with checkpoint inhibitor use for melanoma brain metastases

    Melanoma patients with brain metastases can expect to live longer following the incorporation of checkpoint inhibitors and BRAF -targeted therapies into standard care than their counterparts treated prior to the approval of these agents, suggests an analysis of the US National Cancer Database.

  19. 03-10-2017 | Breast cancer | Article

    Discrepancies between biomarkers of primary breast cancer and subsequent brain metastases: an international multicenter study

    Kaidar-Person, Meattini I, Jain P et al. Breast Cancer Res Treat 2017. doi:10.1007/s10549-017-4526-8

  20. 18-05-2017 | CNS metastases | Article

    Efficacy of anti-PD-1 therapy in patients with melanoma brain metastases

    Parakh et al. find that the anti-programmed death 1 antibodies have significant activity in melanoma patients with brain metastases, including symptomatic patients requiring corticosteroids. Br J Cancer 2017;116:1558–1563. doi:10.1038/bjc.2017.142

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