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5 search results for:

Acalabrutinib 

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  1. 24-08-2020 | Urothelial cancer | News | Article

    Acalabrutinib does not boost pembrolizumab activity in metastatic UC

    Adding the BTK inhibitor acalabrutinib to the PD-1 inhibitor pembrolizumab does not improve outcomes in previously treated patients with metastatic urothelial cancer, results of the phase 2 RAPID CHECK study show.

    Author:
    Laura Cowen
    Published in:
    Cancer 2020; doi:10.1002/cncr.33067 Cancer 2020; doi:10.1002/cncr.33068
  2. 19-12-2017 | Mantle cell lymphoma | News | Article

    Acalabrutinib monotherapy promising for relapsed, refractory mantle cell lymphoma

    Treatment with the second-generation Bruton tyrosine kinase inhibitor acalabrutinib induces durable responses in patients with relapsed or refractory mantle cell lymphoma, indicates the phase II ACE-LY-004 trial.

    Published in:
    Lancet 2017; Advance online publication, ASH 2017; Atlanta, Georgia, USA
  3. 06-11-2017 | FDA | News | Article
    approvalsWatch

    Acalabrutinib receives FDA go-ahead for mantle cell lymphoma

    Common adverse reactions to acalabrutinib include anemia, thrombocytopenia, headache, and neutropenia.

  4. 14-12-2021 | Tyrosine kinase inhibitors | Adis Journal Club | Article
    Targeted Oncology

    Bruton Tyrosine Kinase Inhibitors in B-Cell Malignancies: Their Use and Differential Features

    Subsequently, more-highly selective second-generation BTK inhibitors (including acalabrutinib, zanubrutinib, tirabrutinib and orelabrutinib) have been developed, primarily with an aim to reduce off-target toxicities.

  5. 29-12-2016 | Lymphoma | Article

    The landscape of new drugs in lymphoma

    A randomized controlled trial comparing the efficacy of acalabrutinib with ibrutinib in patients with relapsed CLL is designed to address these issues (NCT02477696).

    Author:
    Anas Younes, Stephen Ansell, Nathan Fowler, Wyndham Wilson, Sven de Vos, John Seymour, Ranjana Advani, Andres Forero, Frank Morschhauser, Marie Jose Kersten, Kensei Tobinai, Pier Luigi Zinzani, Emanuele Zucca, Jeremy Abramson, Julie Vose
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