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medwireNews

‘Dramatically improved’ OS with checkpoint inhibitor use for melanoma brain metastases

Brain mets

Melanoma patients with brain metastases can expect to live longer following the incorporation of checkpoint inhibitors and BRAF-targeted therapies into standard care than their counterparts treated prior to the approval of these agents, suggests an analysis of the US National Cancer Database.

medwireNews@ASCO2018

COLUMBUS OS data favor encorafenib–binimetinib for advanced BRAF-mutated melanoma

An updated analysis of the phase III COLUMBUS trial adds to the evidence supporting a combination of the BRAF inhibitor encorafenib and the MEK inhibitor binimetinib in patients with advanced BRAF V600-mutant melanoma.

medwireNews approvalsWatch

Adjuvant dabrafenib–trametinib approved for mutated melanoma

Drabrafenib

Find out more about this US FDA decision here

medwireNews podcast

SUMIT: Selumetinib in metastatic uveal melanoma

New Content Item (1)

This edition of the medwireNews podcast focuses on a recent trial of the MEK inhibitor selumetinib in metastatic uveal melanoma. Advisory Board member and study author Paul Nathan outlines the findings and discusses the wider implications.

07-05-2019 | Immunotherapy | Highlight | News

Immunotherapy-related AEs reviewed, underlying mechanism postulated

Researchers have comprehensively analyzed the incidence of adverse events in trials of PD-1 and PD-L1 inhibitors, while another team has provided insight into the potential pathophysiologic process underlying these effects.

02-04-2019 | Immunotherapy | Video | Article

Researcher comment: The impact of lifestyle factors on the gut microbiome and immunotherapy response

Christine Spencer outlines her study investigating the effect of diet and supplements on gut microbiota and response to anti-PD-1 therapy in patients with metastatic melanoma, and discusses how the findings may be relevant to other tumor types (3:43).

29-03-2019 | Immunotherapy | News

Flu vaccine not contraindicated for checkpoint inhibitor-treated cancer patients

A US chart review has found no increase in the incidence of severe immune-related adverse events among advanced cancer patients who receive an influenza vaccination during the 2 months before or after initiating immune checkpoint inhibitor therapy.

Practical management guides

01-02-2017 | Melanoma | Practical management guide | Collection

Cutaneous melanoma: A diagnostic guide

Survival rates in the metastatic stage of cutaneous melanoma are poor and therapy is limited, so it is important to detect disease and identify the subtype as early as possible. This illustrated slide set provides a step-by-step guide to diagnosing cutaneous melanoma.

Journal articles and book chapters

20-08-2018 | Metastatic melanoma | Article

Robust prediction of response to immune checkpoint blockade therapy in metastatic melanoma

Auslander N et al. Nat Med 2018; 24: 1545–1549.

05-06-2018 | Radiotherapy | Article

Safety of combining radiotherapy with immune-checkpoint inhibition

Hwang WL et al. Nat Rev Clin Oncol 2018. doi: 10.1038/s41571-018-0046-7

10-04-2018 | Response criteria | Article

iRECIST: guidelines for response criteria for use in trials testing immunotherapeutics

Seymour L et al. Lancet Oncol 2017; 18(3): e143–e152. doi:10.1016/S1470-2045(17)30074-8

07-03-2018 | Immunotherapy | Article

Gastrointestinal toxicity of immune checkpoint inhibitors: from mechanisms to management

Samaan MA et al. Nat Rev Gastroenterol Hepatol 2018; 15:222–234. doi:10.1038/nrgastro.2018.1

06-03-2018 | Immunotherapy | Article

Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges

Fukumura et al. Nat Rev Clin Oncol 2018. doi:10.1038/nrclinonc.2018.29

16-02-2018 | Immunotherapy | Article

Using immunotherapy to boost the abscopal effect

Ngwa W et al. Nat Rev Cancer 2018; 18: 313–322. doi:10.1038/nrc.2018.6

17-01-2018 | Melanoma | Article

Liquid biomarkers in melanoma: Detection and discovery

Lim SY et al. Mol Cancer 2018; 17:8. doi: 10.1186/s12943-018-0757-5

Reference

01-02-2017 | Immunotherapy | Primer | Collection

The fundamentals of cancer immunotherapy

A introductory guide to cancer immunotherapy for non-specialists, focusing primarily on the mechanisms of immune checkpoint inhibition and the role of these agents in anticancer therapy.

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