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medwireNews

‘Dramatically improved’ OS with checkpoint inhibitor use for melanoma brain metastases

Brain mets

Melanoma patients with brain metastases can expect to live longer following the incorporation of checkpoint inhibitors and BRAF-targeted therapies into standard care than their counterparts treated prior to the approval of these agents, suggests an analysis of the US National Cancer Database.

medwireNews@ASCO2018

COLUMBUS OS data favor encorafenib–binimetinib for advanced BRAF-mutated melanoma

An updated analysis of the phase III COLUMBUS trial adds to the evidence supporting a combination of the BRAF inhibitor encorafenib and the MEK inhibitor binimetinib in patients with advanced BRAF V600-mutant melanoma.

medwireNews approvalsWatch

Adjuvant dabrafenib–trametinib approved for mutated melanoma

Drabrafenib

Find out more about this US FDA decision here

medwireNews podcast

SUMIT: Selumetinib in metastatic uveal melanoma

New Content Item (1)

This edition of the medwireNews podcast focuses on a recent trial of the MEK inhibitor selumetinib in metastatic uveal melanoma. Advisory Board member and study author Paul Nathan outlines the findings and discusses the wider implications.

12-12-2018 | Immunotherapy | Feature | Article

Hyperprogression as a response to immunotherapy: ‘A serious downside’

In light of recent reports of hyperprogression in response to treatment with cancer immunotherapy, medwireNews spoke to medical oncologist Razelle Kurzrock (University of California, San Diego, La Jolla, USA) about the phenomenon, the implications for therapy, and future directions for research.

21-11-2018 | Checkpoint blockade | News

Specific cardiovascular toxicities associated with immune checkpoint inhibitor use

Patients treated with immune checkpoint inhibitors are at increased risk for cardiovascular immune-related adverse events including those associated with myocarditis, pericardial disease, and vasculitis, suggests an analysis of the WHO pharmacovigilance database.

01-11-2018 | Immunotherapy | ESMO 2018 | News

Anti-PD-1 immunotherapy feasible for patients with HIV and cancer

A database analysis reported at the ESMO 2018 Congress in Munich, Germany, points to the feasibility of using immune checkpoint inhibitors in people living with HIV who develop cancer.

Practical management guides

01-02-2017 | Melanoma | Practical management guide | Collection

Cutaneous melanoma: A diagnostic guide

An illustrated step-by-step guide to diagnosing cutaneous melanoma.

Journal articles and book chapters

05-06-2018 | Radiotherapy | Article

Safety of combining radiotherapy with immune-checkpoint inhibition

Hwang WL et al. Nat Rev Clin Oncol 2018. doi: 10.1038/s41571-018-0046-7

10-04-2018 | Response criteria | Article

iRECIST: guidelines for response criteria for use in trials testing immunotherapeutics

Seymour L et al. Lancet Oncol 2017; 18(3): e143–e152. doi:10.1016/S1470-2045(17)30074-8

07-03-2018 | Immunotherapy | Article

Gastrointestinal toxicity of immune checkpoint inhibitors: from mechanisms to management

Samaan MA et al. Nat Rev Gastroenterol Hepatol 2018; 15:222–234. doi:10.1038/nrgastro.2018.1

06-03-2018 | Immunotherapy | Article

Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges

Fukumura et al. Nat Rev Clin Oncol 2018. doi:10.1038/nrclinonc.2018.29

16-02-2018 | Immunotherapy | Article

Using immunotherapy to boost the abscopal effect

Ngwa W et al. Nat Rev Cancer 2018; 18: 313–322. doi:10.1038/nrc.2018.6

17-01-2018 | Melanoma | Article

Liquid biomarkers in melanoma: Detection and discovery

Lim SY et al. Mol Cancer 2018; 17:8. doi: 10.1186/s12943-018-0757-5

10-01-2018 | Melanoma | Article

Humanistic burden of disease for patients with advanced melanoma in Canada

Cheung WY et al. Support Care Cancer 2018. doi: 10.1007/s00520-017-4025-9

Reference

01-02-2017 | Immunotherapy | Primer | Collection

The fundamentals of cancer immunotherapy

A introductory guide to cancer immunotherapy for non-specialists, focusing primarily on the mechanisms of immune checkpoint inhibition and the role of these agents in anticancer therapy.

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