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04-04-2019 | TRK inhibitors | Conference coverage | News

LOXO-195 could be an option for tumors resistant to first-generation TRK inhibitors

Early findings point to the antitumor efficacy of the next-generation TRK inhibitor LOXO-195 in patients with NTRK fusion-positive cancers and NTRK resistance mutations acquired during treatment with first-generation agents.

11-09-2017 | Soft-tissue sarcoma | Article

External Beam Radiation Therapy for Resectable Soft Tissue Sarcoma: A Systematic Review and Meta-Analysis

This meta-analysis of sixteen studies shows that the use of preoperative and postoperative external beam radiotherapy may reduce local recurrence of resectable soft tissue sarcomas.

Albertsmeier M et al. Ann Surg Oncol 2017. doi:org/10.1245/s10434-017-6081-2

27-07-2017 | Sarcoma | Article

Surgical treatment of pelvic sarcoma in children: outcomes for twenty six patients

This retrospective analysis of the medical records of young pelvic sarcoma patients shows that promising survival rate and functional outcomes can be obtained after reconstruction and amputation.

Kadhim M. Int Orthop 2017. doi:10.1007/s00264-017-3564-5

24-07-2017 | Soft-tissue sarcoma | Article

Neoadjuvant Radiotherapy is Associated with R0 Resection and Improved Survival for Patients with Extremity Soft Tissue Sarcoma Undergoing Surgery: A National Cancer Database Analysis

This retrospective analysis provides evidence that preoperative radiotherapy increases the likelihood of achieving an oncologically optimal resection in extremity soft tissue sarcoma patients.

Gingrich AA et al. Ann Surg Oncol 2017; 24: 3252-3263. doi:10.1245/s10434-017-6019-8

Screening, diagnosis and staging

09-10-2017 | Sarcoma | Article

Advantages of 18F FDG-PET/CT over Conventional Staging for Sarcoma Patients

This review surveys the promise and pitfalls of using 18F fluorodeoxyglucose-PET/CT imaging for the challenging task of diagnosing, staging and treating sarcomas.

Németh Z et al. Pathol Oncol Res 2017. doi:10.1007/s12253-017-0325-0

31-07-2017 | Atypical fibroxanthoma | Article

Conception and Management of a Poorly Understood Spectrum of Dermatologic Neoplasms: Atypical Fibroxanthoma, Pleomorphic Dermal Sarcoma, and Undifferentiated Pleomorphic Sarcoma

This review sheds light on the controversial area of atypical fibroxanthoma (AFX) and related neoplasms, focusing particularly on diagnosis and management of AFX and pleomorphic dermal sarcoma.

Soleymani T and Hollmig ST. Curr Treat Options Oncol 2017; 18: 50. doi:10.1007/s11864-017-0489-6

17-07-2017 | Soft-tissue sarcoma | Article

Cost–Effectiveness of Surveillance for Distant Recurrence in Extremity Soft Tissue Sarcoma

Results from this cost-effectiveness analysis provide new evidence in the debate on which imaging methods to use for surveillance of distant recurrence in extremity soft tissue sarcoma.

Royce TJ et al. Ann Surg Oncol 2017; 24: 3264–3270. doi:10.1245/s10434-017-5996-y

18-04-2017 | Sarcoma | Article

Uterine adenosarcoma: a review

This article reviews the current state of knowledge concerning uterine adenosarcoma and discusses the management of this rare tumor.

Nathenson MJ et al. Curr Oncol Rep 2016; 18: 68. doi:10.1007/s11912-016-0552-7

Epidemiology and prevention

12-09-2017 | Kaposi sarcoma | Article

The pattern of secondary cancers in patients with Kaposi sarcoma in the United States

This study finds that the absolute risk of non-AIDS-defining secondary cancers is higher in Kaposi sarcoma patients in the HAART era, yet the overall relative risk of secondary cancers has decreased.

Kumar V et al. Cancer Causes Control 2017; 28: 1065-1074. doi:10.1007/s10552-017-0957-0

25-08-2017 | Sarcoma | Article

Clinical features and outcomes of extramedullary myeloid sarcoma in the United States: analysis using a national data set

In the largest study of extramedullary myeloid sarcoma in the US, the authors use the National Cancer Database to describe the clinical features, prognostic factors and early treatment outcomes.

Blood Cancer J 2017; 7: e592. doi:10.1038/bcj.2017.79

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