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20-04-2016 | Pediatric lymphoma | Article

21. Diffuse Large B-Cell Lymphoma in Children and Adolescents (B Mature): Introduction

Authors: Marina K. Servitzoglou, Helen Dana, Apostolos G. Pourtsidis, Fani J. Vlachou, Demetrios N. Exarhos

Publisher: Springer International Publishing


Diffuse large B-cell lymphoma (DLBCL) is a mature B-cell neoplasm, which accounts for approximately 10–20 % of paediatric NHL [1]. In fact, this definition represents a morphologically, immunologically and clinically heterogeneous group of lymphoid neoplasms, rather than one entity [2]. In contrast to other childhood NHL, there is no specific genetic feature for DLBCL. The recent WHO classification delineated some newly defined entities on the basis of distinctive clinical, pathologic or biologic features.

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