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12-01-2016 | Pediatric leukemia | Article

Supplemental folic acid in pregnancy and childhood cancer risk

Abstract

Background

We investigated the association between supplemental folic acid in pregnancy and childhood cancer in a nation-wide study of 687 406 live births in Norway, 1999–2010, and 799 children diagnosed later with cancer.

Methods

Adjusted hazard ratios (HRs) compared cancer risk in children by approximated periconceptional folic acid levels (folic acid tablets and multivitamins (0.6 mg), only folic acid (0.4 mg), only multivitamins (0.2 mg)) and cancer risk in unexposed.

Results

Any folic acid levels were not associated with leukemia (e.g., high-level folic acid HR 1.25; 95% CI 0.89–1.76, PTrend 0.20), lymphoma (HR 0.96; 95% CI 0.42–2.21, PTrend 0.51), central nervous system tumours (HR 0.68; 95% CI 0.42–1.10, PTrend 0.32), neuroblastoma (HR 1.05; 95%CI 0.53–2.06, PTrend 0.85), Wilms’ tumour (HR 1.16; 95% CI 0.52–2.58, PTrend 0.76), or soft-tissue tumours (HR 0.77; 95% CI 0.34–1.75, PTrend 0.90).

Conclusions

Folic acid supplementation was not associated with risk of major childhood cancers.

Br J Cancer 2016; 114: 71–75. doi:10.1038/bjc.2015.446

Authors: Jan Helge Seglem Mortensen, Nina Øyen, Tatiana Fomina, Mads Melbye, Steinar Tretli, Stein Emil Vollset and Tone Bjørge

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