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Pediatric blood cancers

Journal articles and book chapters

06-08-2018 | Guidelines | Article

Management guidelines for paediatric patients receiving chimeric antigen receptor T cell therapy

Mahadeo KM et al. Nat Rev Clin Oncol 2018. doi:10.1038/s41571-018-0075-2.

27-02-2018 | Acute leukemia | Article

Therapy for children and adults with mixed phenotype acute leukemia: a systematic review and meta-analysis

Maruffi M et al. Leukemia 2018. doi:10.1038/s41375-018-0058-4

27-02-2018 | Acute myeloid leukemia | Article

Successes and challenges in the treatment of pediatric acute myeloid leukemia: a retrospective analysis of the AML-BFM trials from 1987 to 2012

Rasche M et al. Leukemia 2018. doi:10.1038/s41375-018-0071-7

19-12-2017 | Pediatric leukemia | Article

Genome-wide DNA methylation is predictive of outcome in juvenile myelomonocytic leukemia

Stieglitz E et al. Nat Commun 2017; doi:10.1038/s41467-017-02178-9

05-12-2017 | Leukemia | Article

Pharmacokinetics of recombinant asparaginase in children with acute lymphoblastic leukemia

Völler G, Pichlmeier U, Zens A & Hempel G. Cancer Chemother Pharmacol 2017. doi:10.1007/s00280-017-3492-5

15-11-2017 | Leukemia | Article

Agents in Development for Childhood Acute Lymphoblastic Leukemia

Maloney KW & Gore L. Pediatr Drugs 2017. doi:10.1007/s40272-017-0268-7

08-11-2017 | Pediatric leukemia | Article

RAS pathway mutations as a predictive biomarker for treatment adaptation in pediatric B-cell precursor acute lymphoblastic leukemia

Jerchel et al. report on their application of next-generation sequencing of 13 RAS pathway genes with a risk-stratified survival analysis in a cohort of pediatric B-cell precursor acute lymphoblastic leukemia patients.

Leukemia DOI: 10.1038/leu.2017.303

13-09-2017 | Pediatric leukemia | Article

Genetic susceptibility in childhood acute lymphoblastic leukemia

The authors review the most important findings regarding genetic susceptibility to childhood acute lymphoblastic leukemia (ALL), specifically the major subtype B-cell precursor ALL, and point to new findings with important implications.

Gutierrez-Camino A et al. Med Oncol 2017; 34: 179. doi:10.1007/s12032-017-1038-7

12-09-2017 | Pediatric leukemia | Article

Residential magnetic fields exposure and childhood leukemia: a population-based case–control study in California

Kheifets L et al. Cancer Causes Control 2017; 28: 1117–1123. doi:10.1007/s10552-017-0951-6

03-07-2017 | Pediatric leukemia | Article

The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia

This article reports an integrated genomic analysis of young subjects with T-lineage acute lymphoblastic leukemia that identifies previously unrecognized mutation targets and modalities of mutation.

Nat Gen 2017; 49: 1211–1218. doi:10.1038/ng.3909

22-05-2017 | Lymphoma | Article

Imaging children suffering from lymphoma: an evaluation of different 18F-FDG PET/MRI protocols compared to whole-body DW-MRI

Kirchner J, Deuschl C, Schweiger B et al. Eur J Nucl Med Mol Imaging 2017; 44: 1742-1750. doi:10.1007/s00259-017-3726-0

03-02-2017 | Pediatric leukemia | Article

Identification of a genetically defined ultra-high-risk group in relapsed pediatric T-lymphoblastic leukemia

In this study, Richter-Pechańska et al. identify a series of potential prognostic biomarkers with utility in treatment stratification in a pediatric cohort of relapsed T-cell acute lymphoblastic leukemia patients.

Richter-Pechańska R et al. Blood Cancer J 2017; 7: e523. doi:10.1038/bcj.2017.3

12-12-2016 | Pediatric leukemia | Article

Cytogenetics and outcome of allogeneic transplantation in first remission of acute myeloid leukemia: the French pediatric experience

Cytogenetic analysis has become a useful tool in the prediction of survival and adaptation of acute myeloid leukemia therapy. Using data from two French studies, Alloin et al. measure the impact of cytogenetic risk stratification.

Alloin A-L et al. Bone Marrow Transplant 2017; 52: 516–521. doi:10.1038/bmt.2016.293

18-11-2016 | Pediatric lymphoma | Article

Non-Hodgkin lymphoma

This chapter reviews the clinical and biological characteristics of non-Hodgkin lymphoma occurring in children, adolescents, and young adults, with particular focus on the nuances of disease in adolescents and young adults.

Hochberg J et al. In: Cancer in Adolescents and Young Adults. Edited by Bleyer A et al. Springer International Publishing AG, 2017. doi:10.1007/978-3-319-33679-4_4

11-11-2016 | Pediatric leukemia | Article

A genome-wide association study identifies risk loci for childhood acute lymphoblastic leukemia at 10q26.13 and 12q23.1

Data from this genome-wide association performed by Vijayakrishnan et al. highlights high-risk loci associated with heritability of childhood acute lymphoblastic leukemia.

Vijayakrishnan J et al. Leukemia 2017; 31: 573–579. doi:10.1038/leu.2016.271

10-10-2016 | Pediatric leukemia | Article

Feasibility of baseline neurocognitive assessment using Cogstate during the first month of therapy for childhood leukemia

Using a battery of computer-based neurocognitive functioning tests (Cogstate) and cerebrospinal fluid biomarkers, Sands et al. investigate early treatment-induced changes in neurocognitive functioning in acute lymphoblastic leukemia patients.

Sands SA et al. Support Care Cancer 2017; 25: 449–457. doi:10.1007/s00520-016-3422-9

12-08-2016 | Pediatric leukemia | Article

A review of new agents evaluated against pediatric acute lymphoblastic leukemia by the Pediatric Preclinical Testing Program

Jones et al. review results from >50 novel agents and combinations tested against the Pediatric Preclinical Testing Program to better determine which agents/combinations are likely to be ineffective in different pediatric acute lymphoblastic leukemia subpopulations.

Jones L et al. Leukemia 2016; 30: 2133–2141. doi:10.1038/leu.2016.192

24-05-2016 | Pediatric leukemia | Article

Childhood leukaemia and distance from power lines in California: A population-based case-control study

Crespi et al. evaluate claims of an increased risk of childhood leukemia associated with living near high-voltage electric power transmission lines that extend to distances at which magnetic fields from lines are negligible.

Crespi CM et al. Br J Cancer 2016; 115: 122–128. doi:10.1038/bjc.2016.142

29-04-2016 | Pediatric lymphoma | Article


This chapter provides an overview of the role of surgery in the management of Hodgkin’s disease and non-Hodgkin’s lymphoma in children.

Billmire DF. In: The Surgery of Childhood Tumors. Edited by Carachi R, Grosfeld JL. Springer-Verlag Berlin Heidelberg, 2016. doi:10.1007/978-3-662-48590-3_21

20-04-2016 | Pediatric lymphoma | Article

Diffuse large B-cell lymphoma in children and adolescents (B mature): introduction

Using a case-based approach, this chapter reviews the clinical characteristics of pediatric diffuse large B-cell lymphoma.

Servitzoglou  MK et al. In:  PET/CT in lymphomas: a case-based atlas. Edited by Andreou JA et al. Springer International Publishing 2016. doi:10.1007/978-3-319-27380-8_21

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