Jerchel et al. report on their application of next-generation sequencing of 13 RAS pathway genes with a risk-stratified survival analysis in a cohort of pediatric B-cell precursor acute lymphoblastic leukemia patients.
The authors review the most important findings regarding genetic susceptibility to childhood acute lymphoblastic leukemia (ALL), specifically the major subtype B-cell precursor ALL, and point to new findings with important implications.
Gutierrez-Camino A et al. Med Oncol 2017; 34: 179. doi:10.1007/s12032-017-1038-7
In this study, Richter-Pechańska et al. identify a series of potential prognostic biomarkers with utility in treatment stratification in a pediatric cohort of relapsed T-cell acute lymphoblastic leukemia patients.
Richter-Pechańska R et al. Blood Cancer J 2017; 7: e523. doi:10.1038/bcj.2017.3
Cytogenetic analysis has become a useful tool in the prediction of survival and adaptation of acute myeloid leukemia therapy. Using data from two French studies, Alloin et al. measure the impact of cytogenetic risk stratification.
Alloin A-L et al. Bone Marrow Transplant 2017; 52: 516–521. doi:10.1038/bmt.2016.293
This chapter reviews the clinical and biological characteristics of non-Hodgkin lymphoma occurring in children, adolescents, and young adults, with particular focus on the nuances of disease in adolescents and young adults.
Hochberg J et al. In: Cancer in Adolescents and Young Adults. Edited by Bleyer A et al. Springer International Publishing AG, 2017. doi:10.1007/978-3-319-33679-4_4
Using a battery of computer-based neurocognitive functioning tests (Cogstate) and cerebrospinal fluid biomarkers, Sands et al. investigate early treatment-induced changes in neurocognitive functioning in acute lymphoblastic leukemia patients.
Sands SA et al. Support Care Cancer 2017; 25: 449–457. doi:10.1007/s00520-016-3422-9
Jones et al. review results from >50 novel agents and combinations tested against the Pediatric Preclinical Testing Program to better determine which agents/combinations are likely to be ineffective in different pediatric acute lymphoblastic leukemia subpopulations.
Jones L et al. Leukemia 2016; 30: 2133–2141. doi:10.1038/leu.2016.192
Crespi et al. evaluate claims of an increased risk of childhood leukemia associated with living near high-voltage electric power transmission lines that extend to distances at which magnetic fields from lines are negligible.
Crespi CM et al. Br J Cancer 2016; 115: 122–128. doi:10.1038/bjc.2016.142