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Medicine Matters is developed for healthcare professionals as

a premier resource for the latest clinical information in medicine.


Concise and thought-provoking commentary, opinion, and analysis from leading oncology experts.

Management of EGFR mutation-positive non-small-cell lung cancer: Two steps forward, looking back

Adenocarcinoma histology

Caroline McCoach (Helen Diller Family Comprehensive Cancer Center, CA, USA) and Howard (Jack) West (Swedish Cancer Institute, WA, USA) discuss the way forward after great progress with tyrosine kinase inhibitors targeting the epidermal growth factor receptor in non-small-cell lung cancer.

Developing polygenic risk scores for breast cancer

3D illustration of a method of DNA sequencing

Gareth Evans (University of Manchester, UK) details how genetic advances have allowed the development of relatively cheap and clinically meaningful genetic-based scores for breast cancer risk, further heralding the shift towards precision medicine in breast cancer.

Choosing an immunotherapy approach in patients with advanced non-small-cell lung cancer

Advanced NSCLC

Liza Villaruz (Hillman Cancer Center, PA, USA) examines recent KEYNOTE trials investigating pembrolizumab for advanced non-small-cell lung cancer and the questions they raise regarding patient selection and combination therapy.

Bipolar androgen therapy: Progress and future directions

Bipolar androgen therapy: Progress and future directions

Michael Schweizer (University of Washington, Seattle, USA) outlines a new therapy that utilizes both androgen deprivation and administration, which may potentially have benefit for prostate cancer patients.

Urinary biomarkers in the management of prostate cancer

Urinary biomarkers in the management of prostate cancer

Non-invasive biomarkers have the potential to guide and improve prostate cancer management in many ways. Maria Frantzi, Agnieszka Latosinska, and Harald Mischak (Mosaiques Diagnostics GmbH, Germany) outline some promising markers and what is needed to implement them in the clinic.

Breast cancer-related lymphedema management: Current state and future directions

Lymphedema management

Breast cancer-related lymphedema is a debilitating complication of breast cancer surgery. Babak Mehrara (Memorial Sloan Kettering Cancer Center, NY, USA) outlines the current state of lymphedema management and poses some questions for the future.

Challenges of an aging and increasingly obese breast cancer survivor population: Are we ready?

Obesity and breast cancer

In an aging population with rising obesity levels, comorbidities and worse overall prognoses for breast cancer patients are a growing concern. Damien Hansra (Cancer Treatment Centers of America, GA, USA) calls for more education and preparation to combat this concerning public health threat.

Discontinuing tyrosine kinase inhibitors in chronic myeloid leukemia

Ehab Atallah

Tyrosine kinase inhibitor (TKI) treatment of chronic myeloid leukemia (CML) can result in prolonged and deep responses in many patients. In such cases, can TKIs be safely discontinued to avoid adverse side effects and costs? Etab Atallah (Medical College of Wisconsin, USA) discusses the current issues surrounding TKI discontinuation in CML.

Pembrolizumab-chemotherapy combination in non-small cell lung cancer

Pembrolizumab-carboplatin-pemetrexed for NSCLC

Two editorial articles provide differing opinions on using pembrolizumab with pemetrexed and platinum chemotherapy for non-small cell lung cancer. In the first article, Stephen Liu argues for embracing this new treatment option, while in the second, Sally Lau and Natasha Leighl argue for a little more caution.

New paradigm: Testing elimination of breast cancer surgery after neoadjuvant systemic therapy

Figure 1

Neoadjuvant chemotherapy can be so effective at shrinking breast tumors in some patients that it has raised the possibility of avoiding surgery altogether. Henry Kuerer (MD Anderson, USA) discusses the exciting recent advances in this area.

16-08-2018 | Non-small cell lung cancer | Article

Management of EGFR mutation-positive non-small-cell lung cancer: Two steps forward, looking back

Caroline McCoach (Helen Diller Family Comprehensive Cancer Center, CA, USA) and Howard (Jack) West (Swedish Cancer Institute, WA, USA) discuss the way forward after great progress with tyrosine kinase inhibitors targeting the epidermal growth factor receptor in non-small-cell lung cancer.

Authors:
Caroline E McCoach MD, PhD, Howard L West MD

02-08-2018 | Breast cancer | Editorial | Article

Developing polygenic risk scores for breast cancer

Gareth Evans (University of Manchester, UK) details how genetic advances have allowed the development of relatively cheap and clinically meaningful genetic-based scores for breast cancer risk, further heralding the shift towards precision medicine in breast cancer.

Author:
Gareth Evans MD, FRCP

26-07-2018 | Non-small cell lung cancer | Editorial | Article

Choosing an immunotherapy approach in patients with advanced non-small-cell lung cancer

Liza Villaruz (Hillman Cancer Center, PA, USA) examines recent KEYNOTE trials investigating pembrolizumab for advanced non-small-cell lung cancer and the questions they raise regarding patient selection and combination therapy.

Author:
Liza C Villaruz MD

06-07-2018 | Prostate cancer | Editorial | Article

Bipolar androgen therapy: Progress and future directions

Michael Schweizer (University of Washington, Seattle, USA) outlines a new therapy that utilizes both androgen deprivation and administration, which may potentially have benefit for prostate cancer patients.

Author:
Michael Schweizer MD

02-07-2018 | Prostate cancer | Editorial | Article

Urinary biomarkers in the management of prostate cancer

Non-invasive biomarkers have the potential to guide and improve prostate cancer management in many ways. Maria Frantzi, Agnieszka Latosinska, and Harald Mischak (Mosaiques Diagnostics GmbH, Germany) outline some promising markers and what is needed to implement them in the clinic.

Authors:
Maria Frantzi MSc, PhD, Agnieszka Latosinska PhD, Harald Mischak MD, PhD

28-06-2018 | Surgery | Editorial | Article

Breast cancer-related lymphedema management: Current state and future directions

Breast cancer-related lymphedema is a debilitating complication of breast cancer surgery. Babak Mehrara (Memorial Sloan Kettering Cancer Center, NY, USA) outlines the current state of lymphedema management and poses some questions for the future.

Author:
Babak J Mehrara MD

01-05-2018 | Obesity | View from the clinic | Article

Body fat and cancer: Why does it matter?

Elevated levels of body fat have consistently been found to be associated with increased risk of a number of cancers. In this 'View from the clinic' article Daniel Nixon (Southeastern Regional Medical Center, USA) explores this relationship and provides his perspective on how to educate and support patients.

Author:
Daniel Nixon MD

23-04-2018 | Survivorship | Editorial | Article

Challenges of an aging and increasingly obese breast cancer survivor population: Are we ready?

In an aging population with rising obesity levels, comorbidities and worse overall prognoses for breast cancer patients are a growing concern. Damien Hansra (Cancer Treatment Centers of America, GA, USA) calls for more education and preparation to combat this concerning public health threat.

Author:
Damien Hansra MD

05-02-2018 | Cancer immunotherapy | View from the clinic | Article

Explaining immunotherapy to our patients with non-small cell lung cancer

Immunotherapy is changing practice in lung cancer, and with this, patient education. In this 'View from the clinic' article, Advisory Board member Beth Eaby-Sandy describes how she explains the new immunotherapy treatments to her patients. 

Author:
Beth Eaby-Sandy MSN, CRNP, OCN

02-02-2018 | Chronic myeloid leukemia | Editorial | Article

Discontinuing tyrosine kinase inhibitors in chronic myeloid leukemia

Tyrosine kinase inhibitor (TKI) treatment of chronic myeloid leukemia (CML) can result in prolonged and deep responses in many patients. In such cases, can TKIs be safely discontinued to avoid adverse side effects and costs? Etab Atallah (Medical College of Wisconsin, USA) discusses the current issues surrounding TKI discontinuation in CML.

Author:
Ehab Atallah MD
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