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13-11-2016 | Ophthalmologic cancers | Article

23. Retinoblastoma: Clinical and Molecular Perspectives

Author: M.D. J. William Harbour

Publisher: Springer New York


Retinoblastoma is a rare eye cancer that has been fundamental to the understanding of tumorigenesis. The RB gene was the first tumor suppressor gene to be discovered, and the Rb protein is targeted for inactivation in the vast majority of human cancers. This chapter reviews the clinical features of retinoblastoma and highlights the insights into molecular oncology that have resulted from study of the Rb tumor suppressor pathway.

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