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05-09-2014 | Ophthalmologic cancers | Article

21. Children’s Oncology Group (COG) Trials for Retinoblastoma

Authors: MD, FACS Dan S. Gombos, MD Anna T. Meadows, MD Murali Chintagumpala, MD Ira J. Dunkel, MD Debra Friedman, PhD Julie Ann Stoner, MD Rima Jubran, MD Judith Grob Villablanca

Publisher: Springer Berlin Heidelberg


For the past 30 years, retinoblastoma, a tumor that occurs in only 3 % of children with cancer, has been the subject of extensive molecular biologic research. However, apart from a short period in the 1970s, retinoblastoma has not been studied by any of the pediatric cooperative groups. The past decade has witnessed significant multidisciplinary prospective clinical and biologic studies of this rare pediatric neoplasm. The Children’s Oncology Group (COG) has successfully opened four clinical trials with a fifth recently approved. This chapter will review these ongoing prospective multicenter trials.

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