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11-04-2018 | Non-small-cell lung cancer | News

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Concomitant mutations linked to poorer response in EGFR mutation-positive NSCLC


medwireNews: In patients with epidermal growth factor receptor (EGFR)-mutated non-small-cell lung cancer (NSCLC), the presence of concomitant mutations in other cancer-related genes is associated with worse outcomes in response to EGFR tyrosine kinase inhibitors (TKIs), Chinese research suggests.

Of 58 patients with metastatic NSCLC who had received first-line EGFR TKIs, over half (55%) had concomitant genetic alterations as shown by next-generation sequencing of cell-free DNA obtained prior to the initiation of treatment.

Patients with co-occurring mutations at baseline had a significantly poorer objective response rate (44 vs 77%), as well as significantly shorter progression-free survival (median 6.20 vs 18.77 months) and overall survival (median 22.70 months vs unreached) than their counterparts with mutations in EGFR alone.

Li Zhang, from the Sun Yat-sen University Cancer Center in Guangzhou, and team write in JAMA Oncology that their “results might challenge the current view that EGFR-mutant NSCLC is a single-oncogene–driven disease.”

They add: “Our study highlights the importance of deploying multiplex molecular profiling and conducting research on the use of polytherapy or sequential therapy to address the coalterations that drive drug resistance.”

By Shreeya Nanda

medwireNews is an independent medical news service provided by Springer Healthcare. © 2018 Springer Healthcare part of the Springer Nature group