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30-06-2016 | Multiple myeloma | Article

Daratumumab: a first-in-class CD38 monoclonal antibody for the treatment of multiple myeloma

Journal:
Journal of Hematology & Oncology

Authors: Larysa Sanchez, Yucai Wang, David S. Siegel, Michael L. Wang

Publisher: BioMed Central

Abstract

Daratumumab is a human monoclonal antibody that targets CD38, a cell surface protein that is overexpressed on multiple myeloma (MM) cells. Preclinical studies have shown that daratumumab induces MM cell death through several mechanisms, including complement-dependent cytotoxicity (CDC), antibody-dependent cell-mediated cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and apoptosis. Given the encouraging efficacy and acceptable safety profile of daratumumab demonstrated in clinical trials, daratumumab has emerged as a novel treatment option for myeloma and became the first monoclonal antibody approved by the FDA for the treatment of MM.

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