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Multiple myeloma

Treatment

17-09-2017 | Multiple myeloma | Article

Acupuncture for reduction of symptom burden in multiple myeloma patients undergoing autologous hematopoietic stem cell transplantation: a randomized sham-controlled trial

In this randomized sham-controlled trial, the authors evaluate the efficacy and safety of acupuncture as an integrative treatment for managing common symptoms during hematopoietic stem cell transplantation in  multiple myeloma patients.

Deng G et al. Support Care Cancer 2017. DOI:10.1007/s00520-017-3881-7

16-09-2017 | Multiple myeloma | Article

Symptom experience of multiple myeloma (syMMex) patients treated with autologous stem cell transplantation following high-dose melphalan: a descriptive longitudinal study

This longitudinal study utilized a 43-item questionnaire (PROVIVO) to measure and compare the symptom experience of multiple myeloma patients before and after high-dose melphalan treatment and autologous stem cell transplantations to guide symptom management and support.

Naegele M et al. Support Care Cancer 2017. DOI:10.1007/s00520-017-3897-z

14-09-2017 | Multiple myeloma | Article

Bortezomib and low-dose dexamethasone with or without continuous low-dose oral cyclophosphamide for primary refractory or relapsed multiple myeloma: a randomized phase III study

This phase III, randomized, controlled study evaluates the bortezomib-dexamethasone plus oral cyclophosphamide regimen versus bortezomib and dexamethasone in patients with primary refractory or relapsed multiple myeloma.

Kropff M et al. Ann Hematol 2017. DOI:10.1007/s00277-017-3065-z

21-08-2017 | Multiple myeloma | Article

Lenalidomide in combination with bendamustine and prednisolone in relapsed/refractory multiple myeloma: results of a phase 2 clinical trial (OSHO-#077)

The authors report the results of their multicenter phase 2 trial which evaluates the safety, tolerability and activity of lenalidomide in combination with bendamustine and prednisolone in patients with relapsed or refractory multiple myeloma.

Beck J et al. J Cancer Res Clin Oncol 2017. DOI:10.1007/s00432-017-2504-5

Screening, diagnosis and staging

29-11-2016 | Hematologic cancers | Article

Nuclear medicine imaging of multiple myeloma, particularly in the relapsed setting

Nuclear imaging is an important tool for diagnosis and response monitoring in patients with multiple myeloma (MM). This article reviews the effectiveness of radiopharmaceuticals that target metabolism, surface receptors and angiogenesis in MM.

de Waal EGM et al. Eur J Nucl Med Mol Imaging 2017; 44: 332–341. doi:10.1007/s00259-016-3576-1

21-10-2016 | Multiple myeloma | Article

Imaging measurable (minimal) residual disease in multiple myeloma

Bhutani et al discuss the shortcomings and advantages of various imaging strategies that can complement current minimal residual disease assessment methodology.

Bhutani M et al. Curr Radiol Rep 2016; 4: 64. doi:10.1007/s40134-016-0192-6

02-10-2016 | Multiple myeloma | Book chapter | Article

MGUS and smoldering multiple myeloma: Diagnosis and epidemiology

This paper reviews the current diagnostic methods, epidemiology, and clinical implications for patients with monoclonal gammopathy of undetermined significance and smoldering multiple myeloma.

Mateos MV & Landgren O. In: Plasma Cell Dyscrasias. Edited by AM Roccaro, IM Ghobrial. Switzerland: Springer International Publishing, 2016. doi:10.1007/978-3-319-40320-5_1

10-05-2016 | Multiple myeloma | Article

MRI in multiple myeloma: a pictorial review of diagnostic and post-treatment findings

The authors discuss the most important imaging findings in patients with multiple myeloma and look at the implications for diagnosis, staging, and response assessment.

Dutoit JC & Verstraete KL. Insights Imaging 2016; 7: 553–569. doi:10.1007/s13244-016-0492-7

Epidemiology

02-09-2016 | Hematologic cancers | Book chapter | Article

Epidemiology of hematologic malignancies

Batista JL, Birmann BM, & Epstein MM. In: Pathology and Epidemiology of Cancer. Edited by Loda M et al. Springer International Publishing, 2017. doi:10.1007/978-3-319-35153-7_29

23-11-2015 | Multiple myeloma | Article

Family history of hematologic malignancies and risk of multiple myeloma: differences by race and clinical features

In this population-based, case-control study, the authors found that an increased risk of multiple myeloma in the Black population and variations in clinical features may be attributed to a shared germline and environmental susceptibility.

VanValkenburg ME et al. Cancer Causes Control 2016; 27: 81–91. doi:10.1007/s10552-015-0685-2

Palliative, supportive and follow-up care

20-03-2018 | Multiple myeloma | Article

Patient-reported outcomes in relapsed/refractory multiple myeloma: a systematic review

Sparano F et al. Support Care Cancer 2018; 26: 2075. doi:10.1007/s00520-018-4137-x

03-03-2018 | Hematologic cancers | Article

Sexual health in patients with hematological malignancies: a neglected issue

Niscola P et al. Support Care Cancer 2018; 26(6): 1699-1701. doi:10.1007/s00520-018-4124-2.

17-09-2017 | Multiple myeloma | Article

Acupuncture for reduction of symptom burden in multiple myeloma patients undergoing autologous hematopoietic stem cell transplantation: a randomized sham-controlled trial

In this randomized sham-controlled trial, the authors evaluate the efficacy and safety of acupuncture as an integrative treatment for managing common symptoms during hematopoietic stem cell transplantation in  multiple myeloma patients.

Deng G et al. Support Care Cancer 2017. DOI:10.1007/s00520-017-3881-7

07-07-2016 | Multiple myeloma | Article

The impact of disease-related symptoms and palliative care concerns on health-related quality of life in multiple myeloma: a multi-centre study

In this original article, the authors conclude that patients with multiple myeloma have a reduced quality of life and that patient-reported outcomes should be used to assess patients in need of supportive care.

Ramsenthaler C et al. BMC Cancer 2016; 16: 427. doi:10.1186/s12885-016-2410-2

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