Esophageal Small-cell Carcinoma with Syndrome of Inappropriate Secretion of Antidiuretic Hormone

Takayuki Ando; Ayumu Hosokawa; Hidemoto Yamawaki; Yuushi Hasumoto; Shinya Kajiura; Yuko Itaya; Akira Ueda; Nobuhiro Suzuki; Jun Nishikawa; Haruka Fujinami; Takako Miyazaki; Kouhei Ogawa; Toshiro Sugiyama

doi:10.2169/internalmedicine.50.4694

CASE REPORTS

Esophageal Small-cell Carcinoma with Syndrome of Inappropriate Secretion of Antidiuretic Hormone

Takayuki Ando, Ayumu Hosokawa, Hidemoto Yamawaki, Yuushi Hasumoto, Shinya Kajiura, Yuko Itaya, Akira Ueda, Nobuhiro Suzuki, Jun Nishikawa, Haruka Fujinami, Takako Miyazaki, Kouhei Ogawa, Toshiro Sugiyama

Author information

Takayuki Ando
Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, Japan
Ayumu Hosokawa
Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, Japan
Hidemoto Yamawaki
Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, Japan
Yuushi Hasumoto
Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, Japan
Shinya Kajiura
Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, Japan
Yuko Itaya
Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, Japan
Akira Ueda
Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, Japan
Nobuhiro Suzuki
Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, Japan
Jun Nishikawa
Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, Japan
Haruka Fujinami
Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, Japan
Takako Miyazaki
Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, Japan
Kouhei Ogawa
Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, Japan
Toshiro Sugiyama
Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, Japan

Keywords: small-cell carcinoma, neuroendocrine tumors, esophagus, SIADH, paraneoplastic syndromes, hyponatremia

JOURNAL OPEN ACCESS

2011 Volume 50 Issue 10 Pages 1099-1103

DOI https://doi.org/10.2169/internalmedicine.50.4694

Details

Abstract

Small-cell carcinoma (SCC) of the esophagus is rare, and its clinical characteristics remain poorly understood. A 54-year-old man was given a diagnosis of esophageal SCC and underwent esophagectomy. Four months after surgery, he was admitted to our hospital because of rapidly developing hyponatremia. Syndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH) due to extensive recurrence of SCC was diagnosed. Combined chemotherapy with irinotecan and cisplatin has dramatically reduced metastatic tumors, and it was concomitantly effective for SIADH. This case demonstrates that esophageal SCC could induce SIADH as a paraneoplastic syndrome and that the above combined chemotherapy was feasible and effective.

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