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Poor Survival Rate in Patients with Postoperative Intra-Abdominal Infectious Complications Following Curative Gastrectomy for Gastric Cancer

  • Gastrointestinal Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

The impact of postoperative complications on recurrence rate and long-term outcome has been reported in patients with colorectal and esophageal cancer, but not in patients with gastric cancer. This study evaluated the impact of postoperative intra-abdominal infectious complications on long-term survival following curative gastrectomy.

Methods

This study included 765 patients who underwent curative gastrectomy for gastric cancer between 2002 and 2006. Patients were divided into 2 groups: with (C-group, n = 81) or without (NC-group, n = 684) intra-abdominal infectious complications. Survival curves were compared between the groups, and multivariate analysis was conducted to identify independent prognostic factors.

Results

Male patients were dominant, and total gastrectomy was frequently performed in the C-group. The pathological stage was more advanced and D2 lymph node dissection and splenectomy were preferred in the C-group. The 5-year overall survival (OS) rate was better in the NC-group (86.8 %) than in the C-group (66.4 %; P < .001). The 5-year relapse-free survival (RFS) rate was also better in the NC-group (84.5 %) than in the C-group (64.9 %; P < .001). This trend was still observed in stage II and III patients after stratification by pathological stage. Multivariate analysis identified intra-abdominal infectious complication as an independent prognostic factor for OS (hazard ratio, 2.448; 95 % confidence interval [95 % CI], 1.475–4.060) and RFS (hazard ratio, 2.219; 95 % CI, 1.330–3.409) in patients with advanced disease.

Conclusions

Postoperative intra-abdominal infectious complications adversely affect OS and RFS. Meticulous surgery is needed to decrease the complication rate and improve the long-term outcome of patients following curative gastrectomy.

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Authors and Affiliations

  1. Division of Gastric Surgery, Shizuoka Cancer Center, Shizuoka, Japan

    Masanori Tokunaga, Yutaka Tanizawa, Etsuro Bando, Taiichi Kawamura & Masanori Terashima

Authors
  1. Masanori Tokunaga
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  2. Yutaka Tanizawa
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  3. Etsuro Bando
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  4. Taiichi Kawamura
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  5. Masanori Terashima
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Corresponding author

Correspondence to Masanori Tokunaga.

Additional information

The present study was presented in part at 2012 Gastrointestinal Cancers Symposium, San Francisco, California, USA, January 19-21, 2012.

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Tokunaga, M., Tanizawa, Y., Bando, E. et al. Poor Survival Rate in Patients with Postoperative Intra-Abdominal Infectious Complications Following Curative Gastrectomy for Gastric Cancer. Ann Surg Oncol 20, 1575–1583 (2013). https://doi.org/10.1245/s10434-012-2720-9

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  • DOI: https://doi.org/10.1245/s10434-012-2720-9

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