Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter to the Editor
  • Published:

Impaired activating receptor expression pattern in natural killer cells from patients with multiple myeloma

Leukemia volume 20, pages 732–733 (2006)Cite this article

Multiple myeloma (MM) is a hematological malignancy characterized by accumulation in the bone marrow of plasma cells that secrete a monoclonal immunoglobulin (Ig). The implication of natural killer cells (NK) in antitumor immunity against MM is suggested by plasmocyte susceptibility to NK lysis.1 NK efficiently kill early-stage MM cells by a natural cytotoxicity receptor (NCR)- and NKG2D-dependent pathway.2 In contrast, late-stage MM cells are protected from NK lysis by a high expression of HLA class I molecules.2 In addition to this immune evasion mechanism involving the target cell,2 we tested the hypothesis of an additional mechanism involving the effector cell, that is, NK, as previously described in leukemic patients.3

We analyzed peripheral NK from six MM patients at diagnosis. The activating receptor expression was checked on CD19−CD3−CD56+ cells by flow cytometry using mAbs against NKp30, NKp44, NKp46, NKG2D, CD16 and 2B4/CD244 (for patient descriptions, see Supplementary Information).

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1

References

  1. Frohn C, Hoppner M, Schlenke P, Kirchner H, Koritke P, Luhm J . Anti-myeloma activity of natural killer lymphocytes. Br J Haematol 2002; 119: 660–664.

    Article  CAS  Google Scholar 

  2. Carbone E, Neri P, Mesuraca M, Fulciniti MT, Otsuki T, Pende D et al. HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells. Blood 2005; 105: 251–258.

    Article  CAS  Google Scholar 

  3. Costello RT, Sivori S, Marcenaro E, Lafage-Pochitaloff M, Mozziconacci MJ, Reviron D et al. Defective expression and function of natural killer cell-triggering receptors in patients with acute myeloid leukemia. Blood 2002; 99: 3661–3667.

    Article  CAS  Google Scholar 

  4. Vitale M, Bottino C, Sivori S, Sanseverino L, Castriconi R, Marcenaro E et al. NKp44, a novel triggering surface molecule specifically expressed by activated natural killer cells, is involved in non-major histocompatibility complex-restricted tumor cell lysis. J Exp Med 1998; 187: 2065–2072.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported by Groupement entreprise française lutte cancer, association pour la recherche contre le cancer, Fédération nationale des centres de lutte contre le cancer, Fondation pour la Recherche Médicale.

Author information

Authors and Affiliations

  1. Laboratoire d'Immunologie des Tumeurs INSERM U599, Institut Paoli-Calmettes, Marseille, France

    C Fauriat, F Mallet, D Olive & R T costello

  2. Département d'Hématologie, Hôpital Nord, Marseille, France

    R T costello

  3. Université de la Méditerranée, Marseille, France

    D Olive & R T costello

Authors
  1. C Fauriat
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F Mallet
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D Olive
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R T costello
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to C Fauriat.

Additional information

Supplementary Information accompanies the paper on the Leukemia website (http://www.nature.com/leu)

Supplementary information

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fauriat, C., Mallet, F., Olive, D. et al. Impaired activating receptor expression pattern in natural killer cells from patients with multiple myeloma. Leukemia 20, 732–733 (2006). https://doi.org/10.1038/sj.leu.2404096

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.leu.2404096

This article is cited by

Search

Advanced search

Quick links