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Non-Myeloablative Stem Cell Transplants

High rate of secondary viral and bacterial infections in patients undergoing allogeneic bone marrow mini-transplantation

Bone Marrow Transplantation volume 26, pages 251–255 (2000)Cite this article

Abstract

New approaches using nonmyeloablative-conditioning regimens have been developed to cause minimal procedure-related toxicity. Such novel therapeutic options are being explored with good preliminary results concerning feasibility and engraftment. However many aspects remain under-evaluated, and few data are available about viral and nonviral infections after these highly immunosuppressive regimens. We present our preliminary data on 21 patients receiving a highly immunosuppressive conditioning strategy, focusing on early infectious complications. Early viral infections before day 45, especially CMV, occurred at a high rate (65%). Furthermore, 33% of patients presented with late bacterial infections (predominately gram negative) although they were not neutropenic compared to conventional conditioning regimens. Although there is presently real interest in these new conditioning regimens which result in reduced immediate transplant-related mortality, it is important that investigators be aware of these pitfalls which may secondarily increase transplant toxicity. Further studies are needed to confirm these findings. Bone Marrow Transplantation (2000) 26, 251–255.

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Authors and Affiliations

  1. Département d'Hématologie, Unité de Transplantation et de Thérapie Cellulaire, Institut Paoli-Calmettes, Marseille, France

    M Mohty, C Faucher, N Vey, AM Stoppa, I Chabbert, C Chabannon, R Bouabdallah, P Ladaique, D Maraninchi & D Blaise

  2. Département d'Oncologie Médicale, Institut Paoli-Calmettes, Marseille, France

    F Viret

  3. Département de Microbiologie, Institut Paoli-Calmettes, Marseille, France

    L Collet

  4. Laboratoire de Virologie, Hôpital La Timone, Marseille, France

    C Zandotti

  5. Université de la Méditerranée, Marseille, France

    D Maraninchi & D Blaise

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  1. M Mohty
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Mohty, M., Faucher, C., Vey, N. et al. High rate of secondary viral and bacterial infections in patients undergoing allogeneic bone marrow mini-transplantation. Bone Marrow Transplant 26, 251–255 (2000). https://doi.org/10.1038/sj.bmt.1702509

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  • DOI: https://doi.org/10.1038/sj.bmt.1702509

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