Abstract
Ovarian failure is often brought about by the conditioning protocol used for bone marrow transplantation (BMT). We monitored ovarian function in 31 girls conditioned for BMT at 10.3 ± 0.6 (s.e., 3.2–17.5) years by chemotherapy alone (group 1, n = 8) or chemotherapy plus body irradiation (12 Gy, fractionated in group 2, n = 9, or 10 Gy single total body in group 3, n = 7, and 5 or 6 Gy single thoraco-abdominal in group 4, n = 7, irradiation) at 13.4 ± 0.4 (11.7–18.6) years. Breast development was normal (n = 11), did not occur (n = 14), or did not progress spontaneously (n = 2) after BMT. The other four girls who menstruated before BMT had permanent amenorrhea. Basal plasma gonadotropin concentrations were measured in 29; follicle- stimulating hormone was increased in them all and luteinizing hormone in 23. At the last clinical evaluation at 16.3 ± 0.4 (12.1–21.6) years, 23 girls had complete ovarian failure, two had partial ovarian failure, and six had normal ovarian function. Three of these were the youngest group 1 patients and those who had not received busulfan. We conclude that conditioning for BMT given during childhood frequently prevents normal estrogen secretion at puberty. Adequate substitutive treatment may be necessary to induce growth acceleration and sexual development.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Thibaud, E., Rodriguez-Macias, K., Trivin, C. et al. Ovarian function after bone marrow transplantation during childhood. Bone Marrow Transplant 21, 287–290 (1998). https://doi.org/10.1038/sj.bmt.1701075
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1701075
Keywords
This article is cited by
-
Late endocrine effects after hematopoietic stem cell transplantation in children with nonmalignant diseases
Bone Marrow Transplantation (2022)
-
Long-term follow-up of high-risk neuroblastoma survivors treated with high-dose chemotherapy and stem cell transplantation rescue
Bone Marrow Transplantation (2021)
-
Anti-Müllerian hormone and Inhibin B after stem cell transplant in childhood: a comparison of myeloablative, reduced intensity and treosulfan-based chemotherapy regimens
Bone Marrow Transplantation (2020)
-
Ovarian transposition
memo - Magazine of European Medical Oncology (2020)