Non-small-cell lung cancers with activating mutations in the epidermal growth factor receptor develop resistance to tyrosine kinase inhibitors by recruiting the MET receptor kinase to activate HER3 and the PI3K-Akt cell survival pathway.
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Arteaga, C. HER3 and mutant EGFR meet MET. Nat Med 13, 675–677 (2007). https://doi.org/10.1038/nm0607-675
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DOI: https://doi.org/10.1038/nm0607-675