Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter to the Editor
  • Published:

ARID5B SNP rs10821936 is associated with risk of childhood acute lymphoblastic leukemia in blacks and contributes to racial differences in leukemia incidence

Leukemia volume 24, pages 894–896 (2010)Cite this article

Subjects

Acute lymphoblastic leukemia (ALL) is the most common malignancy in children, occurring in 32 per million children every year in the United States.1 Racial differences in the incidence of ALL between blacks and whites have been well recognized.2 Based on the Surveillance Epidemiology and End Results Program (SEER) data from 2000 to 2006, the ALL incidence in blacks was 16 per million person-years.1 This was lower than the estimated incidence of 33 per million person-years in non-Hispanic whites, a finding similar to that reported by McNeil.2

We hypothesized that the racial differences in ALL incidence could partly be attributed to differences in allele frequencies between populations of African and European ancestries at disease-associating loci. We have recently identified that germline diversity in the ARID5B gene (SNP rs10821936) was significantly associated with childhood ALL risk in non-Hispanic whites based on a genome-wide association analysis.5 An ARID5B SNP in high linkage disequilibrium with rs10821936 was also associated with ALL risk in an independent study.6 The high-risk genotypes at rs10821936 particularly increased the risk of developing the B-hyperdiploid ALL subtype. Here we performed a case–control analysis to investigate whether genotypes at rs10821936 were also associated with the risk of developing childhood ALL in blacks.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1

References

  1. Surveillance Epidemiology and End Results Program (SEER). Stat Database: Incidence—SEER 17 Regs Limited-use, Katrina/Rita Population Adjustment. 2009 (cited April 2009). Available from: http://www.seer.cancer.gov.

  2. McNeil DE, Cote TR, Clegg L, Mauer A . SEER update of incidence and trends in pediatric malignancies: acute lymphoblastic leukemia. Med Pediatr Oncol 2002; 39: 554–557; discussion 552–553.

    Article  Google Scholar 

  3. Pui CH, Relling MV, Downing JR . Acute lymphoblastic leukemia. N Engl J Med 2004; 350: 1535–1548.

    Article  CAS  Google Scholar 

  4. Pui CH, Sandlund JT, Pei D, Rivera GK, Howard SC, Ribeiro RC et al. Results of therapy for acute lymphoblastic leukemia in black and white children. JAMA 2003; 290: 2001–2007.

    Article  CAS  Google Scholar 

  5. Trevino LR, Yang W, French D, Hunger SP, Carroll WL, Devidas M et al. Germline genomic variants associated with childhood acute lymphoblastic leukemia. Nat Genet 2009; 41: 1001–1005.

    Article  CAS  Google Scholar 

  6. Papaemmanuil E, Hosking FJ, Vijayakrishnan J, Price A, Olver B, Sheridan E et al. Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia. Nat Genet 2009; 41: 1006–1010.

    Article  CAS  Google Scholar 

  7. Greaves M . Infection, immune responses and the aetiology of childhood leukaemia. Nat Rev Cancer 2006; 6: 193–203.

    Article  CAS  Google Scholar 

  8. Mullighan CG, Downing JR . Genome-wide profiling of genetic alterations in acute lymphoblastic leukemia: recent insights and future directions. Leukemia 2009; 23: 1209–1218.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank our protocol co-investigators, clinical and research staff, particularly Pamela McGill, Natalie Lowery, Sean Freeman, Shaherah Amos and Nancy Kornegay, as well as patients and families for their participation. We thank the staff from the Hartwell Center for Bioinformatics and Biotechnology.

Author information

Authors and Affiliations

  1. Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, TN, USA

    W Yang, L R Treviño, J J Yang, W E Evans & M V Relling

  2. Department of Epidemiology, The University of Texas Health Science Center, MD Anderson Cancer Center, Houston, TX, USA

    P Scheet

  3. Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA

    C-H Pui

Authors
  1. W Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L R Treviño
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J J Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P Scheet
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. C-H Pui
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. W E Evans
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. M V Relling
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M V Relling.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yang, W., Treviño, L., Yang, J. et al. ARID5B SNP rs10821936 is associated with risk of childhood acute lymphoblastic leukemia in blacks and contributes to racial differences in leukemia incidence. Leukemia 24, 894–896 (2010). https://doi.org/10.1038/leu.2009.277

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/leu.2009.277

This article is cited by

Search

Advanced search

Quick links