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Extraneural Metastases of Primary Brain Tumors

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Abstract

Extraneural metastasis (ENM) of primary brain tumors is a rare occurence. Based on a critical analysis of the literature the present review focuses on illustrating special common features of these tumors with regard to immunological, cytokinetical and tumorbiological issues. In this respect much can be learned from the specific conditions following organ transplantation which is extensively discussed.

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References

  1. Bailey P, Cushing HA: A Classification of Tumors of the Glioma Group on a Histogenetic Basis with a Correlated Study of Prognosis. 1926, p. 175

  2. Anzil AP: Glioblastoma multiforme with extracranial metastases in the absence of previous craniotomy. Case report. J Neurosurg 33(1): 88–94, 1970

    Google Scholar 

  3. Awad I, Bay JW, Rogers L: Leptomeningeal metastasis from supratentorial malignant gliomas. Neurosurgery 19(2): 247–251, 1986

    Google Scholar 

  4. Dietz R, Burger L, Merkel K, Schimrigk K: Malignant gliomas-glioblastoma multiforme and astrocytoma III-IV with extracranial metastases. Report of two cases: Acta Neurochir (Wien) 57(1–2): 99–105, 1981

    Google Scholar 

  5. Duffner PK, Cohen ME: Extraneural metastases in childhood brain tumors. Ann Neurol 10(3): 261–265, 1981

    Google Scholar 

  6. el-Gindi S, Salama M, el-Henawy M, Farag S: Metastases of glioblastoma multiforme to cervical lymph nodes. Report of two cases. J Neurosurg 38(5): 631–634, 1973

    Google Scholar 

  7. Glasauer FE, Yuan RHP: Intracranial tumors with extracranial metastases. J Neurosurg 20: 474–493, 1963

    Google Scholar 

  8. Hoffman HJ, Becker EL, Jenkin D, Chuang SH, Munro IR: Extraneural metastases of a cerebral astrocytoma. Can J Neurol Sci 8(2): 115–119, 1981

    Google Scholar 

  9. Hulbanni S, Goodman PA: Glioblastoma multiforme with extraneural metastases in the absence of previous surgery. Cancer 37(3): 1577–1583, 1976

    Google Scholar 

  10. Leifer D, Moore T, Ukena T, Wilner D, Thor A, Hedley-Whyte ET: Multifocal glioblastoma with liver metastases in the absence of surgery. Case report. J Neurosurg 71(5 Pt 1): 772–776, 1989

    Google Scholar 

  11. Pasquier B, Pasquier D, Lachard A, N'Golet A, Panh MH, Couderc P: Extraneural metastasis of central nervous system tumours (author's transl). Bull Cancer 66(1): 25–28, 1979

    Google Scholar 

  12. Pasquier B, Pasquier D, N'Golet A, Panh MH, Couderc P: Extraneural metastases of astrocytomas and glioblastomas: clinicopathological study of two cases and review of literature. Cancer 45(1): 112–125, 1980

    Google Scholar 

  13. Pasquier B, Keddari E, Pasquier D, Morens A, Courel MN, Girard N, Delpech B, Couderc P: Spontaneous bone marrow micrometastasis of a cerebral glioma Immunohistochemical diagnosis in a biopsy sample and review of the literature. Ann Pathol 6(2): 130–136, 1986

    Google Scholar 

  14. Smith DR, Hardman JM, Earle KM: Metastasizing neuroectodermal tumors of the central nervous system. J Neurosurg 31(1): 50–58, 1969

    Google Scholar 

  15. Yung WK, Tepper SJ, Young DF: Diffuse bone marrow metastasis by glioblastoma: premortem diagnosis by peroxidase–antiperoxidase staining for glial fibrillary acidic protein. Ann Neurol 14(5): 581–585, 1983

    Google Scholar 

  16. Hoffman HJ, Duffner PK: Extraneural Metastases of Central Nervous System Tumors. Cancer 56: 1778–1782, 1985

    Google Scholar 

  17. Weiss L: A metastasizing ependymoma of the cauda equina. Cancer 8: 161–171, 1955

    Google Scholar 

  18. Dolman CL: Lymph node metastasis as first manifestation of glioblastoma. Case report. J Neurosurg 41(5): 607–609, 1974

    Google Scholar 

  19. Cerame MA, Guthikonda M, Kohli CM: Extraneural metastases in gliosarcoma: a case report and review of the literature. Neurosurgery 17(3): 413–418, 1985

    Google Scholar 

  20. Huang P, Allam A, Taghian A, Freeman J, Duffy M, Suit HD: Growth and metastatic behavior of five human glioblastomas compared with nine other histological types of human tumor xenografts in SCID mice. J Neurosurg 83(2): 308–315, 1995

    Google Scholar 

  21. Forsyth PA, Laing TD, Gibson AW, Rewcastle NB, Brasher P, Sutherland G, Johnston RN, Edwards DR: High levels of gelatinase-B and active gelatinase-A in metastatic glioblastoma. J Neurooncol 36(1): 21–29, 1998

    Google Scholar 

  22. Waite KJ, Wharton SB, Old SE, Burnet NG: Systemic metastases of glioblastoma multiforme. Clin Oncol (R Coll Radiol) 11(3): 205–207, 1999

    Google Scholar 

  23. Wallace CJ, Forsyth PA, Edwards DR: Lymph node metastases from glioblastoma multiforme. AJNR Am J Neuroradiol 17(10): 1929–1931, 1996

    Google Scholar 

  24. Sanerkin NG: Transdural spread of glioblastoma multiforme. J Pathol Bacteriol 84: 228–233, 1962

    Google Scholar 

  25. Jimenez-Jimenez FJ, Garzo-Fernandez C, De Inovencio-Arocena J, Perez-Sotelo M, Castro-De CP, Salinero-Paniagua E: Extraneural metastases from brainstem astrocytoma through ventriculoperitoneal shunt [letter]. J Neurol Neurosurg Psychiatry 54(3): 281–282, 1991

    Google Scholar 

  26. Liwnicz BH, Rubinstein LJ: The pathways of extraneural spread in metastasizing gliomas: a report of three cases and critical review of the literature. Hum Pathol 10(4): 453–467, 1979

    Google Scholar 

  27. Onda K, Tanaka R, Takahashi H, Takeda N, Ikuta F: Cerebral glioblastoma with cerebrospinal fluid dissemination: a clinicopathological study of 14 cases examined by complete autopsy. Neurosurgery 25(4): 533–540, 1989

    Google Scholar 

  28. Jellinger K: Glioblastoma multiforme: morphology and biology. Acta Neurochir (Wien) 42(1–2): 5–32, 1978

    Google Scholar 

  29. Pasquier B, Lachard C, Pasquier D, Couderc P, Delpech B, Courel MN: Glial fibrillary acidic protein and central nervous tumors Immunohistochemical study of a series of 207 cases 1: Astrocytomas Glioblastomas Ependymomas Papillomas of the choroid plexus. Ann Pathol 3(2): 127–135, 1983

    Google Scholar 

  30. Riede U-N, Wehner H. Tumorimmunologie In: Allgemeine und spezielle Pathologie. Thieme Verlag, Stuttgart, New York, 1989, pp 203–206

    Google Scholar 

  31. Kung PC, Bechstein WO, Bakay L: Vascular invasion by glioma cells in man: an electron microscopic study. J Neurosurg 31: 339–345, 1969

    Google Scholar 

  32. Nir I, Levanon D, Iosilevsky G: Permeability of blood vessels in experimental gliomas: uptake of 99mTcglucoheptonate and alteration in blood–brain barrier as determined by cytochemistry and electron microscopy. Neurosurgery 25(4): 523–531, 1989

    Google Scholar 

  33. Pilkington GJ: The paradox of neoplastic glial cell invasion of the brain and apparent metastatic failure. Anticancer Res 17(6B): 4103–4105, 1997

    Google Scholar 

  34. McComb JG: Recent research into the nature of cerebrospinal fluid formation and absorption. J Neurosurg 59(3): 369–383, 1983

    Google Scholar 

  35. Nager GT: Gliomas involving the temporal bone clinical and pathological aspects. Laryngoscope 77(4): 454–488, 1967

    Google Scholar 

  36. Zimmerman HM: The natural history of intracranial neoplasms with special reference to gliomas. Am J Surg 93: 913–924, 1957

    Google Scholar 

  37. Pansera F and Pansera E: An explanation for the rarity of extraaxial metastases in brain tumors. Med Hypotheses 39(1): 88–89, 1992

    Google Scholar 

  38. Maat B, van Zwieten MJ, van Bekkum DW, Vecht C: Transplantability and metastatic potential of chemically induced rat brain tumours. Biomedicine 31(8): 228–230, 1979

    Google Scholar 

  39. Alvord ECJr:Whydo gliomas not metastasize? Arch Neurol 33(2): 73–75, 1976

    Google Scholar 

  40. Hoshino T, Wilson CB: Review of basic concepts of cell kinetics as applied to brain tumors. J Neurosurg 42: 123–131, 1975

    Google Scholar 

  41. Pang D, Ashmead JW: Extraneural metastasis of cerebellar glioblastoma multiforme. Neurosurgery 10(2): 252–257, 1982

    Google Scholar 

  42. Gyepes MT, D'angio GJ: Extracranial metastases from central nervous system tumors in children and adolescents. Radiology 87(1): 55–63, 1966

    Google Scholar 

  43. Lefrancois N, Touraine JL, Cantarovich D, Cantarovich F, Faure JL, Dubernard JM, Dureau G, Colpart JJ, Bouvier R, Traeger J: Transmission of medulloblastoma from cadaver donor to three organ transplant recipients. Transplant Proc 19(1 Pt 3): 2242, 1987

    Google Scholar 

  44. Morse JH, Turcotte JG, Merion RM, Campbell DA Jr, Burtch GD, Lucey MR: Development of a malignant tumor in a liver transplant graft procured from a donor with a cerebral neoplasm. Transplantation 50(5): 875–877, 1990

    Google Scholar 

  45. Ruiz JC, Cotorruelo JG, Tudela V, Ullate PG, Val-Bernal F, de Francisco AL, Zubimendi JA, Prieto M, Canga E, Arias M: Transmission of glioblastoma multiforme to two kidney transplant recipients from the same donor in the absence of ventricular shunt. Transplantation 55(3): 682–683, 1993

    Google Scholar 

  46. Val-Bernal F, Ruiz JC, Cotorruelo JG, Arias M: Glioblastoma multiforme of donor origin after renal transplantation: report of a case (see comments). Hum Pathol 24(11): 1256–1259, 1993

    Google Scholar 

  47. Colquhoun SD, Robert ME, Shaked A, Rosenthal JT, Millis TM, Farmer DG, Jurim O, Busuttil RW: Transmission of CNS malignancy by organ transplantation. Transplantation 57(6): 970–974, 1994

    Google Scholar 

  48. Jonas S, Bechstein WO, Lemmens HP, Neuhaus R, Thalmann U, Neuhaus P: Liver graft-transmitted glioblastoma multiforme. A case report and experience with 13 multiorgan donors suffering from primary cerebral neoplasia (see comments). Transpl Int 9(4): 426–429, 1996

    Google Scholar 

  49. Frank S, Müller J, Bonk C, Haroske G, Schackert HK, Schaefer H-E: Transmission of glioblastoma multiforme through liver transplantation. The Lancet 352, 1998

  50. Pasquier B, Le Marc'hadour F, Peoc'h M, Pasquier D: Accidental transplantation of tumor cells from donors with primary central nervous system tumors (letter; comment). Hum Pathol 25(6): 623–624, 1994

    Google Scholar 

  51. Penn I: Transmission of cancer with donor organs. Transplant Proc 20(5): 739–740, 1988

    Google Scholar 

  52. Detry O, Honore P, Hans MF, Delbouille MH, Jacquet N, Meurisse M: Organ donors with primary central nervous system tumor (see comments). Transplantation 70(1): 244–248, 2000

    Google Scholar 

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Authors and Affiliations

  1. Department of Neurosurgery, University of Wuerzburg, Wuerzburg, Germany

    T. Schweitzer, G.H. Vince, C Herbold, K. Roosen & J.-C. Tonn

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  1. T. Schweitzer
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  2. G.H. Vince
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  3. C Herbold
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  4. K. Roosen
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  5. J.-C. Tonn
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Schweitzer, T., Vince, G., Herbold, C. et al. Extraneural Metastases of Primary Brain Tumors. J Neurooncol 53, 107–114 (2001). https://doi.org/10.1023/A:1012245115209

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