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Parental smoking, CYP1A1 genetic polymorphisms and childhood leukemia (Québec, Canada)

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Abstract

Objective: To evaluate the effect of parental smoking on childhood acute lymphoblastic leukemia and to determine if it is modified by child genetic polymorphisms.

Methods: We carried out a case–control study in Québec, Canada, including 491 incident cases aged 0–9 years and as many healthy controls matched on age and sex. Each parent was interviewed separately with respect to smoking habits during and after pregnancy. In addition, we carried out a case-only substudy with 158 cases classified according to presence or absence of the alleles *2A, *2B, and *4 in the CYP1A1 gene.

Results: There were small risk increases with maternal smoking during the later trimesters. Interaction odds ratios were increased (although often not significantly) for the CYP1A1*4 allele at high levels of maternal smoking in the last trimesters and at low level of paternal postnatal smoking, and decreased for the CYP1A1*2B allele. The latter appeared to confer a protective advantage at low levels for maternal prenatal smoking and at high levels for paternal postnatal smoking.

Conclusions: Reported smoking habits showed no association with leukemia; risks for genetic polymorphisms lacked precision but indicated that the effect of parental smoking could be modified by variant alleles in the CYP1A1 gene.

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Authors and Affiliations

  1. Joint Departments of Epidemiology and Biostatistics, and Occupational Health, Faculty of Medicine, McGill University, 1130 Pine Avenue West, Montréal, Québec, Canada, 3A 1A3;

    Claire Infante-Rivard

  2. Research Center, Hôpital Sainte-Justine, Montréal, Canada

    Claire Infante-Rivard, Maja Krajinovic, Damian Labuda & Daniel Sinnett

  3. Department of Pediatrics, Faculty of Medicine, Université de Montréal, Montréal, Canada

    Damian Labuda & Daniel Sinnett

Authors
  1. Claire Infante-Rivard
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  2. Maja Krajinovic
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  3. Damian Labuda
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  4. Daniel Sinnett
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Infante-Rivard, C., Krajinovic, M., Labuda, D. et al. Parental smoking, CYP1A1 genetic polymorphisms and childhood leukemia (Québec, Canada). Cancer Causes Control 11, 547–553 (2000). https://doi.org/10.1023/A:1008976116512

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