Abstract
We report a case of a 56-year-old male with a primary large cell neuroendocrine renal carcinoma. Grossly, the left kidney was enlarged by a solid tumor that measured 145 × 125 × 100 mm. Histologically, the tumor consisted of large cells with a moderate to abundant amount of eosinophilic cytoplasm. The nuclei were irregular, some of them with finely or coarsely granular chromatin, others with vesicular chromatin and prominent nucleoli. The tumor cells showed multiple mitotic figures (up to 32 mitoses/10 HPF). In some areas, the tumor cells were arranged in solid sheets; however, the predominant pattern was solid-alveolar, trabecular and cribriform. Large areas of tumor necrosis were found. Immunohistochemically, the tumor cells were positive for synaptophysin, CD56 and CD57. Cytokeratin AE1/AE3, vimentin and CD10 were positive only focally. Chromogranin showed weak cytoplasmic positivity in rare tumor cells. Cytokeratin CAM5.2, cytokeratin 34βE12, BerEP 4, EMA, TTF-1, cytokeratin 7, cytokeratin 20, calretinin, serotonin, somatostatin, gastrin, calcitonin, glukagon and insulin were negative. Primary large cell neuroendocrine carcinoma of the kidney is a rare tumor. To the best of our knowledge, only 3 cases of a tumor of this type have been reported to date.
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Abbreviations
- LCNC:
-
large cell neuroendocrine carcinoma
References
Lane BR, Chery F, Jour G et al (2007) Renal neuroendocrine tumours: a clinicopathological study. BJU Int 100:1030–1035
Mazzucchelli R, Morichetti D, Lopez-Beltran A et al (2009) Neuroendocrine tumours of the urinary system and male genital organs: clinical significance. BJU Int. Feb 27. [Epub ahead of print]
Lagace R, Tremblay M (1968) Non-chromaffin paraganglioma of the kidney with distant metastases. Can Med Assoc J 99:1095–1098
Sellaturay SV, Arya M, Banisadr S et al (2006) Primary intrarenal neuroblastoma: A rare, aggressive tumour of childhood mimicking Wilms’ tumour. J Pediatr Urol 2:522–524
Guillou L, Duvoisin B, Chobaz C et al (1993) Combined small-cell and transitional cell carcinoma of the renal pelvis. A light microscopic, immunohistochemical, and ultrastructural study of a case with literature review. Arch Pathol Lab Med 117:239–243
La Rosa S, Bernasconi B, Micello D et al (2008) Primary Small Cell Neuroendocrine Carcinoma of the Kidney: Morphological, Immunohistochemical, Ultrastructural, and Cytogenetic Study of a Case and Review of the Literature. Endocr Pathol 20:24–34
Moukassa D, Leroy X, Bouchind’homme B et al (2000) Primary large cell neuroendocrine carcinoma of the kidney: morphologic and immunohistochemical features of two cases. Ann Pathol 20:357–360
Parada DD, Peña KGB (2008) Chromophobe renal cell carcinoma with neuroendocrine differentiation. APMIS 116:859–865
Kuroda N, Hes O, Miyazaki E et al (2006) Frequent expression of neuroendocrine markers in mucinous tubular and spindle cell carcinoma of the kidney. Histol Histopathol 21:7–10
Kuroda N, Nakamura S, Miyazaki E et al (2004) Low-grade tubular-mucinous renal neoplasm with neuroendocrine differentiation: a histological, immunohistochemical and ultrastructural study. Pathol Int 54:201–207
Armah HB, Parwani AV (2007) Primary carcinoid tumor arising within mature teratoma of the kidney: report of rare entity and review of the literature. Diagn Pathol 2:15
Boix Orri R, Mora Durban MJ, Sánchez Macías J et al (2008) Neuroendocrine tumor in a horseshoe kidney: relative risk of association of two related entities. Arch Esp Urol 61:819–822
Romero FR, Rais-Bahrami S, Permpongkosol S et al (2006) Primary carcinoid tumors of the kidney. J Urol 176:2359–2366
Hansel DE, Epstein JI, Berbescu E et al (2007) Renal carcinoid tumor: a clinicopathologic study of 21 cases. Am J Surg Pathol 31:1539–1544
Chung CH, Park CY (2006) Small cell carcinoma of the kidney. Korean J Intern Med 21:191–193
Capella C, Eusebi V, Rosai J (1984) Primary oat cell carcinoma of the kidney. Am J Surg Pathol 8:855–861
González-Lois C, Madero S, Redondo P et al (2001) Small cell carcinoma of the kidney: a case report and review of the literature. Arch Pathol Lab Med 125:796–798
Kilicarsalan Akkaya B, Mustafa U, Esin O et al (2003) Primary small cell carcinoma of the kidney. Urol Oncol 21:11–13
Kitamura M, Miyanaga T, Hamada M et al (1997) Small cell carcinoma of the kidney: case report. Int J Urol 4:422–424
Masuda T, Oikawa H, Yashima A et al (1998) Renal small cell carcinoma (neuroendocrine carcinoma) without features of transitional cell carcinoma. Pathol Int 48:412–415
Morgan KG, Banerjee SS, Eyden BP (1996) Primary small cell neuroendocrine carcinoma of the kidney. Ultrastruct Pathol 20:141–144
Tetu B, Ro JY, Ayala AG et al (1987) Small cell carcinoma of the kidney. Cancer 60:1809–1814
Pollheimer VS, Bodo K, Pollheimer MJ et al (2007) Merkel cell carcinoma metastasizing to the kidney mimicking primary neuroendocrine renal cancer. APMIS 115:774–777
Ulamec M, Tomas D, Perić-Balja M et al (2008) Neuroendocrine breast carcinoma metastatic to renal cell carcinoma and ipsilateral adrenal gland. Pathol Res Pract 204:851–855
Ricketts R, Tamboli P, Czerniak B et al (2008) Tumor-to-tumor metastasis: report of 2 cases of metastatic carcinoma to angiomyolipoma of the kidney. Arch Pathol Lab Med 132:1016–1020
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This work was supported by Ministry of Education Research Project MSM0021620808.
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Dundr, P., Pešl, M., Povýšil, C. et al. Primary Large Cell Neuroendocrine Carcinoma of the Kidney. Pathol. Oncol. Res. 16, 139–142 (2010). https://doi.org/10.1007/s12253-009-9180-y
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DOI: https://doi.org/10.1007/s12253-009-9180-y