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Homozygosity for the rs9939609T allele of the FTO gene may have protective effect on becoming overweight in survivors of childhood acute lymphoblastic leukaemia

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References

  • Balwierz W., Moryl-Bujakowska A., Skoczeń S., Pawińska K., Balcerska A., Płoszyńska A. et al. 2003 Advances in the treatment of children with high risk acute lymphoblastic leukemia (ALL) treated with modified “NEW YORK” protocols between 1987 and 2002. Przeg. Lek. 60, suppl. 5, 13–16.

  • Barlow S. E. and The Expert Committee 2007 Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity. Pediatrics 120, suppl. 4, 5164–5192.

    Google Scholar 

  • Branca F., Nikogosian H. and Lonstein T. 2007 The challenge of obesity in the WHO European Region and the strategies for response. WHO Europe (www.euro.who.int/document/E90711).

  • Cauchi S., Stutzmann F., Cavalcanti-Proenca C., Durand E., Pouta A., Hartokainen A.-L. et al. 2009 Combined effects of MC4R and FTO common genetic variants on obesity in European general populations. J. Mol. Med. 87, 537–546.

    Article  PubMed  CAS  Google Scholar 

  • Cecil J.-E., Tavendale R., Watt P., Hetherington M.-M. and Palmer C.-N. 2008 An obesity-associated FTO gene variant and increased energy intake in children. N. Engl. J. Med. 359, 2558–2566.

    Article  PubMed  CAS  Google Scholar 

  • Chow E. J., Pihoker C., Hunt K., Wilkinson K. and Friedman D.-L. 2007 Obesity and hypertension among children after treatment for acute lymphoblastic leukemia. Cancer 110, 2313–2320.

    Article  PubMed  Google Scholar 

  • Dina C., Meyre D., Gallina S., Durand E., Korner A. and Jacobson P. 2007 Variation in FTO contributes to childhood obesity and severe adult obesity. Nat. Genet. 39, 724–726.

    Article  PubMed  CAS  Google Scholar 

  • Do R., Bailey S.-D., Desbiens K., Belisle A., Montpetit A., Bouchard C. et al. 2008 Genetic variants of FTO influence adiposity, insulin sensitivity, leptin levels, and resting metabolic rate in the Quebec family study. Diabetes 57, 1147– 1150.

    Article  PubMed  CAS  Google Scholar 

  • Frayling T.-M., Timpson N.-J., Weedon M.-N., Zeggini E., Freathy R.-M., Lindgren C.-M. et al. 2007 A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316, 889–894.

    Article  PubMed  CAS  Google Scholar 

  • Gregory J.-W. and Reilly J.-J. 2004 Body composition and obesity. In Late effects of childhood cancer (ed. H. Wallace and D. Green), pp.145–161. Arnold Publishers, London, UK.

    Google Scholar 

  • Hinney A., Nguyen T.-T., Scherag A., Friedel S., Bronner G., Muller T.-D. et al. 2007 Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants. PLoS ONE 12, e1361.

    Google Scholar 

  • Janiszewski P.-M., Oeffinger K.-C., Church T.-S., Dunn A. L., Eshelman D. A., Victor R.-G. et al. 2007 Abdominal obesity, liver fat, and muscle composition in survivors of childhood acute lymphoblastic leukemia. J. Clin. Endocrinol. Metab. 92, 3816–3821.

    Article  PubMed  CAS  Google Scholar 

  • Krebs N.-F., Himes J.-H., Jacobson D., Nicklas T.-A., Guilday P., Styne D. 2007 Assessment of child and adolescent overweight and obesity. Pediatrics 120, suppl. 4, 5164–5192.

    Google Scholar 

  • Link K., Moëll C., Garwicz S., Cavallin-Stahl E., Bjork J., Thilen U. et al. 2004 Growth hormone deficiency predicts cardiovascular risk in young adults treated for acute lymphoblastic leukemia in childhood. J. Clin. Endocrinol. Metab. 89, 5003–5012.

    Article  PubMed  CAS  Google Scholar 

  • Radwanska U., Michalewska D., Armata J., Balwierz W., Boguslawska-Jaworska J. and Cyklis R. 1989 Acute lymphoblastic leukemia therapy in Poland. Folia Haematol. 116, 199–210.

    CAS  Google Scholar 

  • Radwanska U., Michalewska D., Kolecki P., Armata J., Balwierz W., Boguslawska-Jaworska J. et al. 1995 Standard and intermediate risk acute lymphoblastic leukemia in Poland. A report of the Polish children leukemia/lymphoma study group. Acta Paediatr. Jpn. 37, 31–36.

    Article  PubMed  CAS  Google Scholar 

  • Reinehr T., Hinney A., Toschke A.-M. and Hebebrand J. 2009 Aggravating effect of INSIG2 and FTO on overweight reduction in a one-year lifestyle intervention. Arch. Dis. Child. 94, 965–967.

    Article  PubMed  CAS  Google Scholar 

  • Ross J.-A., Oeffinger K.-C., Davies S.-M., Mertens A.-C., Langer E.-K., Kiffmeyer W.-R. et al. 2004 Genetic variation in the leptin receptor gene and obesity in survivors of childhood acute lymphoblastic leukemia: a report from the childhood cancer survivor study. J. Clin. Oncol. 22, 3558–3562.

    Article  PubMed  CAS  Google Scholar 

  • Zhao J., Bradfield J.-P., Li M., Wang K., Zhang H., Kim C.-E. et al. 2009 The role of obesity-associated loci identified ingenome-wide association studies in the determination of pediatric BMI. Obesity 17, 2254–2257.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Chair of Clinical Immunology and Transplantation, Jagiellonian University Medical College, 30-663, Krakow, Poland

    SKOCZEN SZYMON & JOLANTA GOZDZIK

  2. Chair of Pediatrics, Jagiellonian University Medical College, 30-663, Krakow, Poland

    MIROSLAW BIK-MULTANOWSKI & JACEK J. PIETRZYK

  3. Department of Pediatric Oncology and Hematology, Polish-American Institute of Pediatrics, Jagiellonian University Medical College, 30-663, Krakow, Poland

    WALENTYNA BALWIERZ & WOJCIECH STROJNY

  4. Department of Medicine, Jagiellonian University Medical College, 30-663, Krakow, Poland

    MARCIN SURMIAK

  5. Department of Metabolic Diseases, Jagiellonian University Medical College, 30-663, Krakow, Poland

    DANUTA GALICKA-LATALA

Authors
  1. SKOCZEN SZYMON
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  2. MIROSLAW BIK-MULTANOWSKI
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  3. WALENTYNA BALWIERZ
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  4. JACEK J. PIETRZYK
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  5. MARCIN SURMIAK
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  6. WOJCIECH STROJNY
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  7. DANUTA GALICKA-LATALA
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  8. JOLANTA GOZDZIK
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Correspondence to SKOCZEN SZYMON.

Additional information

[Szymon S., Bik-Multanowski M., Balwierz W., Pietrzyk J. J., Surmiak M., Strojny W., Galicka-Latala D. and Gozdzik J. 2011 Homozygosity for the rs9939609T allele of the FTO gene may have protective effect of becoming overweight in survivors of childhood acute lymphoblastic leukaemia. J. Genet. 90, 365–368]

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SZYMON, S., BIK-MULTANOWSKI, M., BALWIERZ, W. et al. Homozygosity for the rs9939609T allele of the FTO gene may have protective effect on becoming overweight in survivors of childhood acute lymphoblastic leukaemia . J Genet 90, 365–368 (2011). https://doi.org/10.1007/s12041-011-0089-3

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  • DOI: https://doi.org/10.1007/s12041-011-0089-3

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