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Outcome of non-metastatic male breast cancer: 118 patients

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Abstract

Studies concerning adjuvant systemic therapy and prognosis in male breast carcinoma (MBC) are limited. We aimed to evaluate outcome of the changing practices of adjuvant systemic treatment and survival in operable MBC patients over the last two decades. The medical records of 148 MBC patients followed between the years 1986 and 2009 at 7 cancer center were evaluated retrospectively. One hundred and eighteen operable non-metastatic patients had sufficient data were included the study. One hundred and eighteen operable MBC were found to be eligible. Median age was 60 (range 29–83) years. Thirty-two percent of the patients had T3-4 tumors. Half of the patients had axillary lymph node-positive disease. The proportion of positivity of estrogen receptor(ER), progesterone receptor (PgR), and HER2 status were 82.9, 75.8, and 23.4%, respectively. Only, 7 patients had triple negative (TN). Adjuvant hormonotherapy was advised for 76.8% whereas adjuvant chemotherapy for 73.7% of the patients. Median follow-up was 40.9 months (range 3.8–186 months). Locoregional and/or distant recurrence developed in thirty-eight patients (32.2%). Twenty-three patients died during the follow-up period. Five-year disease-free survival (DFS) was found to be 60%, whereas overall survival (OS) was 82%. Larger tumor size and lymph node positivity were statistically significant poor prognostic factors for OS. Although statistical insignificant, patients with HER2-positive tumors have worse DFS (52 vs. 120 months, log rank P = .73) and OS (85 vs. 144 months, log rank P = .30) than HER2-negative ones. Although the frequency of the use of adjuvant systemic therapy in MBC has been increasing and survival rates improving for the last decades, lymph node status and tumor size are still the most important determining factors for prognosis. There is a need for further prognostic information in men with HER2-positive or TN breast cancer.

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Authors and Affiliations

  1. Department of 2nd Medical Oncology, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Turkey

    Ülkü Yalçıntaş Arslan, Berna Öksüzoğlu, Necati Alkış, Ayşe Gök, Ümmügül Üyetürk & İbrahim Türker

  2. Department of Medical Oncology, Ankara Numune Education and Research Hospital, 06100, Sihhiye, Ankara, Turkey

    Nuriye Özdemir, Sercan Aksoy, Doğan Uncu & Abdurrahman Işıkdoğan

  3. Department of Medical Oncology, Dicle University Faculty of Medicine, Diyarbakır, Turkey

    Mehmet Ali Kaplan

  4. Department of Medical Oncology, Dr. Lütfi Kırdar Kartal Education and Research Hospital, Istanbul, Turkey

    Mahmut Gümüş

  5. Department of Medical Oncology, Erciyes University Faculty of Medicine, Kayseri, Turkey

    Veli Berk

  6. Department of Medical Oncology, Gazi University Faculty of Medicine, Ankara, Turkey

    Meltem Baykara

  7. Department of Medical Oncology, Dışkapı Yıldırım Beyazıt Education and Research Hospital, Ankara, Turkey

    Dilşen Çolak

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  1. Ülkü Yalçıntaş Arslan
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Arslan, Ü.Y., Öksüzoğlu, B., Özdemir, N. et al. Outcome of non-metastatic male breast cancer: 118 patients. Med Oncol 29, 554–560 (2012). https://doi.org/10.1007/s12032-011-9978-9

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  • DOI: https://doi.org/10.1007/s12032-011-9978-9

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