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Cigarette smoking, alcohol drinking, and risk of lymphoid neoplasms: results of a French case–control study

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Abstract

Objective

To study potential role of smoking and alcohol in lymphoid neoplasms (LN).

Methods

A case–control study that included 824 cases and 752 hospital controls aged 18–75 years was conducted. Cases were newly diagnosed with non-Hodgkin’s or Hodgkin’s lymphoma, multiple myeloma, or lymphoproliferative syndrome (LPS). Controls were matched with the cases by gender, age, and center.

Results

Overall, smoking was not related to LN. However, average tobacco consumption tended to be inversely related to non-Hodgkin’s lymphoma (NHL), LPS, and the hairy cell leukemia (HCL) subtype, with a significant negative trend for the latter (OR of 0.4, 0.2, 0.1 for consumptions of ≤10, 11–20, >20 cig/day). An inverse association between ‘ever drinking’ and Hodgkin’s lymphoma (HL: OR = 0.5 [0.3–0.8]) and NHL (OR = 0.7 [0.5–1.0]) was evidenced and restricted to the diffuse large B-cell lymphoma subtype, with significant negative trends. The controls’ smoking and drinking habits were similar to those of French population. The results remained unchanged after adjustment for potential confounding factors and when smoking and drinking were both included in the models.

Conclusion

Results are consistent with those of several previous studies and suggest a direct or indirect protective effect of smoking with respect to HCL although based on small numbers. The negative relationship between alcohol consumption and Hodgkin’s and NHL, also previously reported, needs further investigations.

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Acknowledgments

This work was supported by grants from the Association pour la Recherche contre le Cancer, the Fondation de France, and AFSSET, and a donation from Faberge employees. The authors are grateful to Sandra Leguyader-Peyrou, Marie-Astrid Caillet, Satya Garnier-Haoussine, Virginie Duchenet, Véronique Chaigneau, Anne-Laure Demarty, Dominique Gillet, and Magali Viaud, who contributed to the interviews, and to Martine Valdes, Christine Henry, Nathalie Jourdan-Da Silva, and Dominique Ridondelli, for technical assistance. The authors would also like to express their gratitude to the heads of department who helped them include patients as controls: Professors Vital, Durandeau, and Le Guillou in Bordeaux, Lefevre and Le Goff in Brest, Vielpeau and Marcelli in Caen, Migaux, Duquesnois and Mazeman in Lille, Passuti and Maugars in Nantes, and Mansat and Fournier in Toulouse; to Isabelle Soubeyran, who helped with the revision of the diagnoses; and to the staff of the Hematological Malignancies Registry of Gironde, who helped with the classification and coding. We are grateful to Jean-Louis Lanöe for his help with national health statistics and to Andrew Mullarky for his skillful revision of the manuscript.

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Authors and Affiliations

  1. Inserm U754, 94800, Villejuif Cedex, France

    A. Monnereau, L. Orsi, D. Hemon & J. Clavel

  2. Paris-Sud University, UMR-S754, IFR69, 94800, Villejuif, France

    A. Monnereau, L. Orsi, D. Hemon & J. Clavel

  3. Comprehensive Cancer Center, Bergonié Institute, 33076, Bordeaux Cedex, France

    A. Monnereau & P. Soubeyran

  4. Côte de Nacre Hospital, Caen, France

    X. Troussard & M. Leporrier

  5. Morvan Hospital, Brest, France

    C. Berthou

  6. Avicenne Hospital, Bobigny, France

    P. Fenaux

  7. Haut-Lévêque Hospital, CHU Bordeaux, Pessac, France

    G. Marit

  8. Purpan Hospital, Toulouse, France

    F. Huguet

  9. Hôtel Dieu Hospital, Nantes, France

    N. Milpied

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  1. A. Monnereau
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  2. L. Orsi
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  3. X. Troussard
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  4. C. Berthou
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  12. J. Clavel
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Correspondence to A. Monnereau.

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Monnereau, A., Orsi, L., Troussard, X. et al. Cigarette smoking, alcohol drinking, and risk of lymphoid neoplasms: results of a French case–control study. Cancer Causes Control 19, 1147–1160 (2008). https://doi.org/10.1007/s10552-008-9182-1

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  • DOI: https://doi.org/10.1007/s10552-008-9182-1

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