Abstract
In this paper the association between smoking history, beverage consumption, diet and bladder cancer incidence is systematically reviewed. A rating system has been used to summarise the level of scientific evidence (i.e. convincing, probable, possible, and no evidence) and the level of association (i.e. substantially increased, (RR≥2.5), moderately increased (1.5≤RR<2.5), slightly increased (1.2≤RR<1.5), no association (0.8≤RR<1.2), slightly decreased (0.7≤RR<0.8), moderately decreased (0.4≤RR<0.7), and substantially decreased (RR<0.4)). There is convincing evidence that cigarette smoking status, frequency and duration substantially increase the risk of bladder cancer. However, the evidence is not clear for other forms of smoking. A small increased risk for cigar, pipe, and environmental smoking is only possible. There is possible evidence that total fluid intake is not associated with bladder cancer. Although there is convincing evidence for a positive association between alcohol consumption and bladder cancer risk in men, the risk is small and not clinically relevant. Coffee and tea consumption are probably not associated with bladder cancer. The authors conclude that total fruit consumption is probably associated with a small decrease in risk. There is probably no association between total vegetable intake, vitamin A intake, vitamin C intake and bladder cancer and a possibly moderate inverse association with vitamin E intake. Folate is possibly not associated with bladder cancer. There probably is a moderate inverse association between selenium intake and bladder cancer risk.
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References
Steward BW, Kleinhaus P (2003) World Cancer Report. WHO-IARC, Lyon
Lousbergh D, et al (2003) Incidence of cancer in the Belgian province of Limburg. LIKAS, Hasselt
Visser O, Coeberg J, Dijck van J, Siesling S (2002) Incidence of cancer in the Netherlands 1998. Association of comprehensive cancer centres, Utrecht
Schottenfeld D, Fraumeni JF (1996) Cancer epidemiology and prevention. Oxford University Press, New York, Oxford
van der Meijden (1998) APM bladder cancer. British Medical Journal 317:1366–1369
Bruyninckx R, Buntinx F, Aertgeerts B, Van Casteren V (2003) The diagnostic value of macroscopic haematuria for the diagnosis of urological cancer in general practice. Br J Gen Pract 53:31–35
Buntinx F, Wauters H (1997) The diagnostic value of macroscopic haematuria in diagnosing urological cancers: a meta-analysis. Fam Pract 14:63–68
van der Windt DA, Zeegers MP, Kemper HC, Assendelft WJ, Scholten RJ (2000) Practice of systematic reviews. VI. Searching, selection and methodological evaluation of etiological research. Ned Tijdschr Geneeskd 144:1210–1214
van den Brandt PA, et al (1990) A large-scale prospective cohort study on diet and cancer in the Netherlands. J Clin Epidemiol 43:285–95
van den Brandt PA, Schouten LJ, Goldbohm RA, Dorant E, Hunen PHM (1990) Development of a record linkage protocol for use in the Dutch cancer registry for epidemiological research. Int J Epidemiol 19:553–558
Barlow WE (1994) Robust variance estimation for the case-cohort design. Biometrics 50:1064–1072
Barlow WE, Ichikawa L, Rosner D, Izumi S (1999) Analysis of case-cohort designs. J Clin Epidemiol 52:1165–1172
Zeegers MP, Goldbohm RA, van den Brandt PA (2001) Consumption of vegetables and fruits and urothelial cancer incidence: a prospective study. Cancer Epidemiol Biomarkers Prev 10:1121–1128
Zeegers MP, Goldbohm RA, van den Brandt, PA (2001) Are retinol, vitamin C, vitamin E, folate and carotenoids intake associated with bladder cancer risk? Results from the Netherlands Cohort Study. Br J Cancer 85:977–983
Zeegers MP, Dorant E, Goldbohm RA, van den Brandt PA (2001) Are coffee, tea, and total fluid consumption associated with bladder cancer risk? Results from the Netherlands Cohort Study. Cancer Causes Control 12:231–238
Zeegers MP, Volovics A, Dorant E, Goldbohm RA, van den Brandt PA (2001) Alcohol consumption and bladder cancer risk: results from The Netherlands Cohort Study. Am J Epidemiol 153:38–41
Zeegers MP, Goldbohm RA, Bode P, van den Brandt PA (2002) Prediagnostic toenail selenium and risk of bladder cancer. Cancer Epidemiol Biomarkers Prev 11:1292–1297
Zeegers MP, Goldbohm RA, van den Brandt PA (2002) A prospective study on active and environmental tobacco smoking and bladder cancer risk (The Netherlands). Cancer Causes Control 13:83–90
World Cancer Research Fund & American Institute for Cancer Research (1997) Food, nutrition and the prevention of cancer: a global perspective. Banta Book Group, Menasha
Rothman K, Greenland S (1998) Modern epidemiology. Lippincott-Raven Publishers, Philadelphia
Sommer F, Klotz T, Schmitz-Dräger BJ (2004) Lifestyle issues and genitourinary tumours. World J Urol (in press) DOI 10.1007/s00345-003-0379-3
Zeegers MP, Tan FE, Dorant E, van Den Brandt PA (2000) The impact of characteristics of cigarette smoking on urinary tract cancer risk: a meta-analysis of epidemiologic studies. Cancer 89:630–639
Brennan P, et al (2000) Cigarette smoking and bladder cancer in men: a pooled analysis of 11 case-control studies. Int J Cancer 86:289–294
Brennan P, et al (2001) The contribution of cigarette smoking to bladder cancer in women (pooled European data). Cancer Causes Control 12:411–417
Castelao JE, et al (2001) Gender- and smoking-related bladder cancer risk. J Natl Cancer Inst 93:538–545
Matanoski GM, Elliott EA (1981) Bladder cancer epidemiology. Epidemiol Rev 3:203–229
Morrison AS (1984) Control of cigarette smoking in evaluating the association of coffee drinking and bladder cancer. In: MacMahon B, Sugimura T (eds) Coffee and health. Cold Spring Harbor Laboratory, Spring Harbor, pp 127–136
Dolin PJ (1991) An epidemiological review of tobacco use and bladder cancer. J Smoking Related Dis 2:129–143
Silverman DT, Hartge P, Morrison AS, Devesa SS (1992) Epidemiology of bladder cancer. Hematol Oncol Clin North Am 6:1–30
Shirai T (1993) Etiology of bladder cancer. Semin Urol 11:113–126
Shirai T, et al (1995) The etiology of bladder cancer: are there any new clues or predictors of behavior? Int J Urol 2[Suppl 3]: 64–75
Silverman DT, Morrison AS, Devesa SS (1996) Bladder cancer. In: Schottenfeld D, Fraumeni JF (eds) Cancer epidemiology and prevention. Oxford University Press, New York, Oxford, pp 1156–79
Ross RK, Jones PA, Yu MC (1996) Bladder cancer epidemiology and pathogenesis. Semin Oncol 23:536–545
Johansson SL, Cohen SM (1997) Epidemiology and etiology of bladder cancer. Semin Surg Oncol 13:291–298
Howe GR, et al (1980) Tobacco use, occupation, coffee, various nutrients, and bladder cancer. J Natl Cancer Inst 64:701–713
Burch JD, et al (1989) Risk of bladder cancer by source and type of tobacco exposure: a case-control study. Int J Cancer 44:622–628
Jensen OM, Wahrendorf J, Blettner M, Knudsen JB, Sorensen BL (1987) The Copenhagen case-control study of bladder cancer: role of smoking in invasive and non-invasive bladder tumours. J Epidemiol Community Health 41:30–36
Claude J, et al (1986) Life-style and occupational risk factors in cancer of the lower urinary tract. Am J Epidemiol 124:578–589
Hartge P, Hoover R, Kantor A (1985) Bladder cancer risk and pipes, cigars and smokeless tobacco. Cancer 15:901–906
Steineck G, Norell SE, Feychting M (1988) Diet, tobacco and urothelial cancer: a 14-year follow-up of 16,477 subjects. Acta Oncol 27:323–327
Morrison AS, et al (1984) An international study of smoking and bladder cancer. Journal d Urologie 131:650–654
Sandler DP, Everson RB, Wilcox AJ (1985) Passive smoking in adulthood and cancer risk. Am J Epidemiol 121:37–48
Morrison AS, Cole P (1976) Epidemiology of bladder cancer. Urol Clin North Am 3:13–29
Vineis P (1992) Epidemiological models of carcinogenesis: the example of bladder cancer. Cancer Epidemiol Biomarkers Prev 1:149–153
Sandler DP, Wilcox AJ, Everson RB (1985) Cumulative effects of lifetime passive smoking on cancer risk. Lancet 1:312–315
Bos RP, Theuws JL, Henderson PT (1983) Excretion of mutagens in human urine after passive smoking. Cancer Lett 19:85–90
Jensen OM, Wahrendorf J, Knudsen JB, Sorensen BL (1986) The Copenhagen case-control study of bladder cancer. II. Effect of coffee and other beverages. Int J Cancer 37:651–657
Kunze E, Chang Claude J, Frentzel Beyme R (1992) Life style and occupational risk factors for bladder cancer in Germany. A case-control study. Cancer 69:1776–1790
Vena JE, et al (1993) Drinking water, fluid intake and bladder cancer in western New York. Arch Environ Health 48:191–198
Cantor KP, et al (1987) Bladder cancer, drinking water source, and tap water consumption: a case-control study. J Natl Cancer Inst 79:1269–1279
Bianchi GD, et al (2000) Tea consumption and risk of bladder and kidney cancers in a population-based case-control study. Am J Epidemiol 151:377–383
Risch HA, et al (1988) Dietary factors and the incidence of cancer of the urinary bladder. Am J Epidemiol 127:1179–1191
Slattery ML, West DW, Robison LM (1988) Fluid intake and bladder cancer in Utah. Int J Cancer 42:17–22
Dunham LJ, Rabson AS, Steward HS, Frank A, Young JL (1968) Rates, interview, and pathology study of cancer of the urinary bladder in New Orleans, Louisiana. J Natl Cancer Inst 41:683–709
Wilkens LR, Kadir MM, Kolonel LN, Nomura AM, Hankin JH (1996) Risk factors for lower urinary tract cancer: the role of total fluid consumption, nitrites and nitrosamines, and selected foods. Cancer Epidemiol Biomarkers Prev 5:161–166
Mills PK, Beeson WL, Phillips RL, Fraser GE (1991) Bladder cancer in a low risk population: results from the Adventist Health Study. Am J Epidemiol 133:230–239
Michaud DS, et al Fluid intake and the risk of bladder cancer in men. N Engl J Med 340:1390–1397 (1999)
Zeegers MP, Tan FE, Goldbohm RA, van den Brandt PA (2001) Are coffee and tea consumption associated with urinary tract cancer risk? A systematic review and meta-analysis. Int J Epidemiol 30:353–362
World Health Organization (1991) IARC monographs on the evaluation of carcinogenic risks to humans: coffee, tea, mate, methylxanthines and methylgloxal. World Health Organization, Lyon
Nehlig A, Debry G (1996) Coffee and cancer: a review of human and animal data. World Rev Nutr Diet 79:185–221
Negri E, La Vecchia C (2001) Epidemiology and prevention of bladder cancer. Eur J Cancer Prev 10:7–14
Jones PA, Ross RK (1999) Prevention of bladder cancer. N Engl J Med 340:1424–1426
Blot WJ (1999) Invited commentary: more evidence of increased risks of cancer among alcohol drinkers. Am J Epidemiol 150:1138–1140
Berger A (1998) Science commentary: why wine might be less harmful than beer and spirits. BMJ 317:848
Seitz HK, Simanowski UA (1988) Alcohol and carcinogenesis. Annu Rev Nutr 8:99–119
Garro AJ, Lieber CS Alcohol and cancer. Annu Rev Pharmacol Toxicol 30:219–49 (1990)
Freund G (1979) Possible relationships of alcohol in membranes to cancer. Cancer Res 39:2899–2901
Lopez-Abente G, Escolar A (2001) Tobacco consumption and bladder cancer in non-coffee drinkers. J Epidemiol Community Health 55:68–70
Yang CS, Wang ZY (1993) Tea and cancer. J Natl Cancer Inst 85:1038–1049
Goldbohm RA, Hertog MG, Brants HA, van Poppel G, van den Brandt PA (1996) Consumption of black tea and cancer risk: a prospective cohort study. J Natl Cancer Inst 88:93–100
Dreosti IE, Wargovich MJ, Yang CS (1997) Inhibition of carcinogenesis by tea: the evidence from experimental studies. Crit Rev Food Sci Nutr 37:761–770
Dreosti IE (1996) Bioactive ingredients: antioxidants and polyphenols in tea. Nutr Rev 54: S51–S58
Katiyar SK, Mukhtar H (1996) Tea consumption and cancer. World Rev Nutr Diet 79:154–184
Steinmaus CM, Nunez S, Smith AH (2000) Diet and bladder cancer: a meta-analysis of six dietary variables. Am J Epidemiol 151:693–702
Michaud DS, et al (2002) Intakes of fruits and vegetables, carotenoids and vitamins A, E, C in relation to the risk of bladder cancer in the ATBC cohort study. Br J Cancer 87:960–965
Michaud DS, et al (2000) Prospective study of dietary supplements, macronutrients, micronutrients, and risk of bladder cancer in US men [In Process Citation]. Am J Epidemiol 152:1145–1153
Riboli E, et al (1991) Diet and bladder cancer in Spain: a multi-centre case-control study. Int J Cancer 49:214–219
Vena JE, et al (1992) Diet in the epidemiology of bladder cancer in western New York. Nutr Cancer 18:255–264
Shibata A, Paganini Hill A, Ross RK, Henderson BE (1992) Intake of vegetables, fruits, beta-carotene, vitamin C and vitamin supplements and cancer incidence among the elderly: a prospective study. Br J Cancer 66:673–679
Nomura AMY, Kolonel LN, Hankin JH, Yoshizawa CN (1991) Dietary factors in cancer of the urinary tract. Int J Cancer 48:199–205
Kolonel LN, Hinds MW, Nomura AM, Hankin JH, Lee J (1985) Relationship of dietary vitamin A and ascorbic acid intake to the risk for cancers of the lung, bladder, and prostate in Hawaii. Natl Cancer Inst Monogr 69:137–142
Bruemmer B, White E, Vaughan TL, Cheney CL (1996) Nutrient intake in relation to bladder cancer among middle-aged men and women. Am J Epidemiol 144:485–495
Nomura A, Heilbrun LK, Morris JS, Stemmermann GN (1987) Serum selenium and the risk of cancer, by specific sites: case-control analysis of prospective data. J Natl Cancer Inst 79:103–108
Helzlsouer KJ, Comstock GW, Morris JS (1989) Selenium, lycopene, alpha-tocopherol, beta-carotene, retinol, and subsequent bladder cancer. Cancer Res 49:6144–6148
Knekt P, et al (1990) Serum selenium and subsequent risk of cancer among Finnish men and women. J Natl Cancer Inst 82:864–868
Garland M, et al (1995) Prospective study of toenail selenium and cancer among women. J Natl Cancer Inst 87:497–505
Steinmetz KA, Potter JD (1996) Vegetables, fruit, and cancer prevention: a review. J Am Diet Assoc 96:1027–1039
Steinmetz KA, Potter JD (1991) Vegetables, fruit, and cancer. II. Mechanisms. Cancer Causes Control 2:427–442
Patterson RE, White E, Kristal AR, Neuhouser ML, Potter JD (1997) Vitamin supplements and cancer risk: the epidemiologic evidence. Cancer Causes Control 8:786–802
Kamat AM, Lamm DL (1999) Chemoprevention of urological cancer. J Urol 161:1748–1760
Birt DF (1986) Update on the effects of vitamins A, C, and E and selenium on carcinogenesis. Proc Soc Exp Biol Med 183:311–320
Knekt P, et al (1988) Serum vitamin E and risk of cancer among Finnish men during a 10-year follow-up. Am J Epidemiol 127:28–41
Glynn SA, Albanes D (1994) Folate and cancer: a review of the literature. Nutr Cancer 22:101–119
Blount BC, et al (1997) Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci U S A 94:3290–3295
Clark LC, et al (1996) Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin: a randomized controlled trial. JAMA 276:1957–1963
Salonen JT, Alfthan G, Huttunen JK, Puska P (1984) Association between serum selenium and the risk of cancer. Am J Epidemiol 120:342–349
Willett WC, et al (1983) Prediagnostic serum selenium and risk of cancer. Lancet 2:130–134
Virtamo J, et al (1987) Serum selenium and risk of cancer. A prospective follow-up of nine years. Cancer 60:145–148
Fan AM, Kizer KW (1990) Selenium: nutritional, toxicologic and clinical aspects. West J Med 153:160–167
Brockmoller J, Kerb R, Drakoulis N, Staffeldt B, Roots I (1994) Glutathione S-transferase M1 and its variants A and B as host factors of bladder cancer susceptibility: a case-control study. Cancer Res 54:4103–4111
Brockmoller J, Cascorbi I, Kerb R, Roots I (1996) Combined analysis of inherited polymorphisms in arylamine N- acetyltransferase 2, glutathione S-transferases M1 and T1, microsomal epoxide hydrolase, and cytochrome P450 enzymes as modulators of bladder cancer risk. Cancer Res 56:3915–3925
Marcus PM, et al (2000) Cigarette smoking, N-acetyltransferase 2 acetylation status, and bladder cancer risk: a case-series meta-analysis of a gene-environment interaction. Cancer Epidemiol Biomarkers Prev 9:461–467
Spurr NK, Gough AC, Chinegwundoh FI, Smith CA (1995) Polymorphisms in drug-metabolizing enzymes as modifiers of cancer risk. Clin Chem 41:1864–1869
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Zeegers, M.P.A., Kellen, E., Buntinx, F. et al. The association between smoking, beverage consumption, diet and bladder cancer: a systematic literature review. World J Urol 21, 392–401 (2004). https://doi.org/10.1007/s00345-003-0382-8
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DOI: https://doi.org/10.1007/s00345-003-0382-8