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Dynamic contrast-enhanced 3-T MR imaging in cervical cancer before and after concurrent chemoradiotherapy

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Abstract

Objective

To investigate the changes of dynamic contrast-enhanced MR imaging (DCE-MRI) parameters at 3 T in cervical cancer patients before and after concurrent chemoradiotherapy (CCRT), and to correlate the parameters with final tumour response to therapy.

Methods

Thirty-five patients with cervical cancer underwent DCE-MRI before CCRT, 4 weeks after starting therapy and at 1 month after the end of therapy. DCE-MRI parameters were calculated in the tumour and normal gluteus muscle. Final response to treatment as determined by changes in tumour size and volume was correlated with pre-treatment DCE-MRI parameters.

Results

DCE-MRI parameters (i.e. K trans, v e and k ep) in the tumours showed significant changes in response to CCRT (P < 0.05) and in particular K trans and v e demonstrated early significant increase (P < 0.01), but those in normal muscle did not show a significant difference (P > 0.05). Before therapy, the mean values of K trans, k ep, v e and v p in the tumours were significantly greater than those in muscle (P < 0.05). DCE-MRI parameters of the tumours at pre-treatment were not statistically associated with final tumour size or volume change.

Conclusion

DCE-MRI parameters may help evaluate early changes of cervical cancer to CCRT, but larger, more definitive studies are needed.

Key Points

• DCE-MRI offers new insights into tumour behaviour.

• Changes in tumour size lag behind biomarkers which improve quickly in responders.

• DCE-MRI is a non-invasive imaging technique that can characterize tumour vasculature.

• DCE-MRI of cervical cancer may be useful in monitoring changes with therapy.

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Authors and Affiliations

  1. Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Gangnam-gu, Seoul, Republic of Korea, 135-710

    Jae-Hun Kim, Chan Kyo Kim, Byung Kwan Park & Sung Yoon Park

  2. Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

    Seung Jae Huh

  3. Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN, USA

    Bohyun Kim

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  1. Jae-Hun Kim
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  2. Chan Kyo Kim
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  3. Byung Kwan Park
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  4. Sung Yoon Park
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  5. Seung Jae Huh
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Correspondence to Chan Kyo Kim.

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Kim, JH., Kim, C.K., Park, B.K. et al. Dynamic contrast-enhanced 3-T MR imaging in cervical cancer before and after concurrent chemoradiotherapy. Eur Radiol 22, 2533–2539 (2012). https://doi.org/10.1007/s00330-012-2504-4

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  • DOI: https://doi.org/10.1007/s00330-012-2504-4

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