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USPIO-enhanced MRI for preoperative staging of gynecological pelvic tumors: preliminary results

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Abstract

The aim of this study was to assess nodal enhancement with ultrasmall superparamagnetic iron oxide (USPIO)-enhanced magnetic resonance imaging (MRI) during preoperative staging of gynecological pelvic tumors within the same imaging session for the primary tumor. Pelvic MRI was performed 18–28 h after intravenous infusion of USPIO (Combidex/Sinerem, 2.6 mg Fe/kg body weight) in 13 women (mean age 51 years) scheduled for surgery for biopsy proven (n=11) or clinically suspected (n=2) uterine carcinoma. Axial T1-weighted spin-echo (SE), T2-weighted fast SE (FSE; with fat saturation), fast spoiled gradient-recalled (FSPGR) echo, sagittal and oblique T2-weighted FSE sequences were acquired on a 1.5-T system. Lymph nodes were prospectively staged using standard criteria, i.e., size and shape, as well as USPIO enhancement. Results were correlated with histology findings. MRI correctly staged all primary uterine tumors. In one case, the preoperative diagnosis of stage IV switched the therapeutic approach to radiochemotherapy. Ninety-one (86 benign, 5 malignant) of the histologically characterized nodes could be correlated with their MRI counterparts. One node was false positive; three micrometastases greater than 5 mm and one 5-mm metastasis were missed. On a nodal basis, the sensitivity score was 0.33 and the specificity score, 0.99. On a patient basis, the sensitivity score was 0.25 and the specificity score, 0.80. Our preliminary results indicate that USPIO-enhanced pelvic MRI for preoperative nodal assessment is feasible within one imaging session for primary tumors and that it has a high specificity. However, the low sensitivity in the present study is a limitation for the clinical application of this technique.

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Acknowledgments

The study was partly supported by a grant from the Frau Henriette Rossiez-Treichler Legacy, Zurich, Switzerland.

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Authors and Affiliations

  1. Institute of Diagnostic Radiology, Zurich University Hospital, Zurich, Switzerland

    Thomas M. Keller, Sven C. A. Michel, Borut Marincek & Rahel A. Kubik-Huch

  2. Guerbet Group, Zurich, Switzerland

    Johannes Fröhlich

  3. Department of Gynecology, Zurich University Hospital, Zurich, Switzerland

    Daniel Fink

  4. Department of Pathology, Zurich University Hospital, Zurich, Switzerland

    Rosmarie Caduff

  5. Department of Radiology, Kantonsspital Baden, 5404, Baden, Switzerland

    Rahel A. Kubik-Huch

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  1. Thomas M. Keller
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  2. Sven C. A. Michel
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  7. Rahel A. Kubik-Huch
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Correspondence to Rahel A. Kubik-Huch.

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Keller, T.M., Michel, S.C.A., Fröhlich, J. et al. USPIO-enhanced MRI for preoperative staging of gynecological pelvic tumors: preliminary results. Eur Radiol 14, 937–944 (2004). https://doi.org/10.1007/s00330-004-2258-8

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  • DOI: https://doi.org/10.1007/s00330-004-2258-8

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