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Preoperative [18F]FDG PET/CT maximum standardized uptake value predicts recurrence of uterine cervical cancer

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European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

Abstract

Purpose

To determine if preoperative [18F]FDG-PET/CT imaging has prognostic significance in patients with uterine cervical cancer.

Methods

Patients with FIGO stage IB to IIA cervical cancer were imaged with integrated FDG PET/CT before radical surgery. The relationship between the maximum standardized uptake value (SUVmax) of FDG in the primary tumour during PET/CT and recurrence was examined.

Results

Included in the study were 75 patients. Medical records including clinical data, treatment modalities, and treatment results were retrospectively reviewed. The median duration of follow-up was 13 months (range 3 to 58 months) after treatment. Median preoperative SUVmax values in the primary tumours were significantly higher in patients with higher FIGO stages (p = 0.0149), pelvic lymph node metastasis (p = 0.0068), parametrial involvement (p = 0.0002), large (>4 cm) tumour size (p = 0.0022), presence of lymphovascular space invasion (p = 0.0055), and deep cervical stromal invasion (p < 0.0001). In univariate analysis, lymph node metastasis, parametrial invasion, presence of lymphovascular space invasion, and preoperative SUVmax (uncategorized values) in the primary tumour were significantly associated with recurrence. However, in multivariate analysis, preoperative SUVmax (p = 0.014, HR 1.178, 95% CI 1.034–1.342), age (p = 0.021, HR 0.87, 95% CI 0.772–0.980), and parametrial involvement (p = 0.040, HR 27.974, 95% CI 1.156–677.043) by primary tumour were significantly associated with recurrence.

Conclusion

Preoperative FDG uptake by the primary tumour showed a significant association with recurrence in patients with uterine cervical cancer.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul, 110-744, Republic of Korea

    Hyun Hoon Chung, Jae Weon Kim, Noh-Hyun Park, Yong-Sang Song & Soon-Beom Kang

  2. Division of Cancer Epidemiology and Management, Research Institute, National Cancer Center, Seoul, Republic of Korea

    Byung-Ho Nam

  3. Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea

    Keon Wook Kang & June-Key Chung

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  1. Hyun Hoon Chung
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Correspondence to Jae Weon Kim.

Additional information

Hyun Hoon Chung and Byung-Ho Nam contributed equally to this work.

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Chung, H.H., Nam, BH., Kim, J.W. et al. Preoperative [18F]FDG PET/CT maximum standardized uptake value predicts recurrence of uterine cervical cancer. Eur J Nucl Med Mol Imaging 37, 1467–1473 (2010). https://doi.org/10.1007/s00259-010-1413-5

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  • DOI: https://doi.org/10.1007/s00259-010-1413-5

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