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Chromosomal localization of three humanras genes by in situ molecular hybridization

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Somatic Cell and Molecular Genetics

Abstract

Three human rasfamily protooncogenes, c-Ki-ras-1, and c-Ki-ras-2, and N-ras,have been mapped to chromosome bands 6p11–12, 12p11.1–12.1, and 1p11–13, respectively by in situ molecular hybridization. Certain human cancers display consistent and specific alterations involving chromosomes 1, 6, and 12. The precise chromosomal localization of ras genes will permit evaluation of thepossible effect of these chromosome changes on the structure and activities of ras protooncogenes in human neoplasia.

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Author notes

  1. N. C. Popescu & D. C. Swan

    Present address: Center for Infectious Diseases, Molecular Virology Branch, Center for Disease Control, 30333, Atlanta, Georgia

Authors and Affiliations

  1. Laboratory of Biology, National Cancer Institute, National Institutes of Health, 20205, Bethesda, Maryland

    N. C. Popescu, S. C. Amsbaugh & J. A. DiPaolo

  2. Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, 20205, Bethesda, Maryland

    S. R. Tronick, S. A. Aaronson & D. C. Swan

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  1. N. C. Popescu
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Popescu, N.C., Amsbaugh, S.C., DiPaolo, J.A. et al. Chromosomal localization of three humanras genes by in situ molecular hybridization. Somat Cell Mol Genet 11, 149–155 (1985). https://doi.org/10.1007/BF01534703

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  • DOI: https://doi.org/10.1007/BF01534703

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