Abstract
The biological effects brought about by the selective accumulation of 35S-labelled methylthionine bromide (MTB) in pigmented hamster melanoma cells were examined in vitro and in vivo.
In vitro incubation of melanoma cells in 35S-carrier-containing medium was found to suppress mitotic activity within 150 h whereas the same concentration of an inactive carrier did not affect normal proliferation.
If the cells were in contact for 3 h with 35S-carrier in non-toxic concentration before reimplantation into the skin, a clear-cut correlation between 35S radioactivity and the capacity of growth initiation could be found. The growth of melanoma in situ could also be delayed by injecting the 35S-carrier to tumour-bearing animals.
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Link, E., Łukiewicz, S. A new radioactive drug selectively accumulating in melanoma cells. Eur J Nucl Med 7, 469–473 (1982). https://doi.org/10.1007/BF00253084
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DOI: https://doi.org/10.1007/BF00253084