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Acute Lymphoblastic Leukemia: Epidemiology and Etiology

  • Chapter
Acute Leukemias

Part of the book series: Hematologic Malignancies ((HEMATOLOGIC))

Abstract

Acute lymphoblastic leukemia (ALL), also known as acute lymphocytic leukemia, is a malignant neoplasm of the lymphocyte precursor cells, or lymphoblasts, that occurs annually in nearly 4000 people in the US [51]. Leukemic lymphoblasts have exaggerated and uncontrolled growth, fail to mount a normal immune response, and cause a drop in production of normal bone marrow cells that leads to a deficiency of circulating red cells (anemia), platelets (thrombocytopenia), and white cells other than lymphocytes (especially neutrophils, or neutropenia) [146]. Both T-cell and B-cell precursors can give rise to ALL; B-cell ALL represents about 88% of all cases.

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References

  1. Acquavella JF, Leonard RC (2001) A review of the epidemiology of 1,3-butadiene and chloroprene. Chem Biol Interact 135–136:43–52

    PubMed  Google Scholar 

  2. Adami J, Nyren O, Bergstrom R, Ekbom A, Engholm G, Englund A, et al. (1998) Smoking and the risk of leukemia, lymphoma, and multiple myeloma. Cancer Causes Control 9:49–56

    PubMed  CAS  Google Scholar 

  3. Ahlbom A, Day N, Feychting M, Roman E, Skinner J, Dockerty J, et al. (2000) A pooled analysis of magnetic fields and childhood leukemia. Br J Cancer 83:692–698

    PubMed  CAS  Google Scholar 

  4. Aksoy M, Erdem S, Dincol G (1976) Types of leukemia in a chronic benzene poisoning: A study in thirty-four patients. Acta Haematologica 55:65–72

    PubMed  CAS  Google Scholar 

  5. Alexander FE, Chan LC, Lam TH, Yuen P, Leung NK, Ha SY, et al. (1997) Clustering of childhood leukaemia in Hong Kong: Association with the childhood peak and common acute lymphoblastic leukaemia and with population mixing. Br J Cancer 75:457–463

    PubMed  CAS  Google Scholar 

  6. Auvinen A, Kurttio P, Pekkanen J, Pukkala E, Ilus T, Salonen L (2002) Uranium and other natural radionuclides in drinking water and risk of leukemia: A case-cohort study in Finland. Cancer Causes Control 13:825–829

    PubMed  Google Scholar 

  7. Badrinath P, Day NE, Stockton D (1997) Seasonality in the diagnosis of acute lymphocytic leukaemia. Br J Cancer 75:1711–1713

    PubMed  CAS  Google Scholar 

  8. Berrington A, Darby SC, Weiss HA, Doll R (2001) 100 years of observation on British radiologists: Mortality from cancer and other causes 1897–1997. Br J Radiol 74:507–519

    PubMed  CAS  Google Scholar 

  9. Boffetta P, Tredaniel J, Greco A (2000) Risk of childhood cancer and adult lung cancer after childhood exposure to passive smoke: A meta-analysis. Environ Health Perspect 108:73–82

    PubMed  CAS  Google Scholar 

  10. Boice JD, Jr, Bigbee WL, Mumma MT, Blot WJ (2003) Cancer mortality in counties near two former nuclear materials processing facilities in Pennsylvania, 1950–1995. Health Physics 85:691–700

    PubMed  CAS  Google Scholar 

  11. Borkhardt A, Cazzaniga G, Viehmann S, Valesecchi MG, Ludwig WD, Burci L, et al. (1977) Incidence and clinical relevance of TEL/AML1 fusion genes in children with acute lymphoblastic leukemia enrolled in the German and Italian multicenter therapy trials. Blood 90:571–577

    Google Scholar 

  12. Borugian MJ, Spinelli JJ, Mezei G, Wilkins R, Abanto Z, McBride ML (2005) Childhood leukemia and socioeconomic status in Canada. Epidemiology 16:526–531

    PubMed  Google Scholar 

  13. Buffler PA, Kwan MI, Reynolds P, Urayama KY (2005) Environmental and genetic risk factors for childhood leukemia: Appraising the evidence. Cancer Invest 1:60–75

    Google Scholar 

  14. Cardis E, Vrijheid M, Blettner M, Gilbert E, Hakama M, Hill C, et al. (2005) Risk of cancer after low doses of ionizing radiation: Retrospective cohort study in 15 countries. Br Med J 331:77–82

    CAS  Google Scholar 

  15. Cave H, Cacheux V, Raynaud S, Brunie G, Bakkus M, Cochaux P, et al. (1997) ETV6 is the target of chromosome 12p deletions in t(12;21) childhood acute lymphocytic leukemia. Leukemia 11:1459–1464

    PubMed  CAS  Google Scholar 

  16. Cimino G, Lo Coco F, Biondi A, Elia L, Luciano A, Croce CM, et al. (1993) ALL-1 gene at chromosome 11q23 is consistently altered in acute leukemia of early infancy. Blood 82:544–546

    PubMed  CAS  Google Scholar 

  17. Collman G, Loomis D, Sandler D (1991) Childhood cancer mortality and radon concentration in drinking water in North Carolina. Br J Cancer 63:626–629

    PubMed  CAS  Google Scholar 

  18. Colt JS, Blair S (1998) Parental occupational exposures and risk of childhood cancers. Environ Health Perspect 106(Suppl):909–925

    PubMed  Google Scholar 

  19. Crosignani P, Tittarelli A, Borgini A, Codazzi T, Rovelli A, Porro E, et al. (2004) Childhood leukemia and road traffic: A populationbased case-control study. Int J Cancer 108(4):596–599

    PubMed  CAS  Google Scholar 

  20. Darby SC, Doll R, Gill SK, Smith PG (1987) Long term mortality after a single treatment course with X-rays in patients treated for ankylosing spondylitis. Br J Cancer 55:179–190

    PubMed  CAS  Google Scholar 

  21. Dickinson HO, Parker L (1999) Quantifying the effect of population mixing on childhood leukemia risk: The Seascale cluster. Br J Cancer 81:144–151

    PubMed  CAS  Google Scholar 

  22. Feychting M, Ahlbom A (1993) Magnetic fields and cancer in children residing near Swedish high-voltage power lines. Am J Epidemiol 138:467–481

    PubMed  CAS  Google Scholar 

  23. Feychting M, Svensson D, Ahlbom A (1998) Exposure to motor vehicle exhaust and childhood cancer. Scand J Work Env Health 24:8–11

    CAS  Google Scholar 

  24. Floderus B, Persson T, Stenlund C, Wennberg A, Ost A, Knave B (1993) Occupational exposure to electromagnetic fields in relation to leukemia and brain tumors: A case-control study in Sweden. Cancer Causes Control 4:465–476

    PubMed  CAS  Google Scholar 

  25. Foliart DE, Pollock BH, Mezei G, Iriye R, Silva JM, Ebi KL, et al. (2006) Magnetic field exposure and long-term survival among children with leukemia. Br J Cancer 94:161–164

    PubMed  CAS  Google Scholar 

  26. Freedman DM, Stewart P, Kleinerman RA, Wacholder S, Hatch EE, Tarone R, et al. (2001) Household solvent exposures and childhood acute lymphoblastic leukemia. Am J Public Health 91: 564–567

    PubMed  CAS  Google Scholar 

  27. Fritschi L, Ambrosini GL, Kliewer EV, Johnson KC, Canadian Cancer Registries Epidemiologic Research Group (2004) Dietary fish intake and risk of leukaemia, multiple myeloma, and non-Hodgkin lymphoma. Cancer Epidemiol Biomarkers Prev 13(4):532–537

    PubMed  CAS  Google Scholar 

  28. Fulton J, Cobb S, Preble L, Leone L, Forman E (1980) Electrical wiring configurations and childhood leukemia in Rhode Island. Am J Epidemiol 111:292–296

    PubMed  CAS  Google Scholar 

  29. Fuortes L (1990) Leukemia incidence and radioactivity in drinking water in 59 Iowa towns. Am J Public Health 80:1261–1262

    PubMed  CAS  Google Scholar 

  30. Gardner MJ (1991) Childhood cancer and nuclear installations. Public Health 105:277–285

    PubMed  CAS  Google Scholar 

  31. Gardner MJ, Hall AJ, Downes S, Terrell JD (1987) Follow up study of children born elsewhere but attending schools in Seascale, West Cumbria (schools cohort). Br Med J 295:819–827

    CAS  Google Scholar 

  32. Gardner MJ, Snee MP, Hall AJ, Powell CA, Downes S, Terrell JD (1990) Results of case-control study of leukaemia and lymphoma among young people near Sellafield nuclear plant in West Cumbria. Br Med J 300:423–429

    CAS  Google Scholar 

  33. Gilbert ES, Land CE, Simon SL (2002) Health effects from fallout. Health Physics 82:726–735

    PubMed  CAS  Google Scholar 

  34. Golub TR, Barker GF, Bohlander SK, Hiebert SW, Ward DC, Bray-Ward P, et al. (1995) Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia. Proc Natl Acad Sci 92:4917–4921

    PubMed  CAS  Google Scholar 

  35. Greaves MF (1988) Speculations on the cause of childhood acute lymphoblastic leukemia. Leukemia 2:120–125

    PubMed  CAS  Google Scholar 

  36. Greaves MF (1997) Aetiology of acute leukemia. Lancet 349:344–349

    PubMed  CAS  Google Scholar 

  37. Greaves MF (1999) Molecular genetics, natural history and the demise of childhood leukemia. Eur J Cancer 35:1941–1953

    PubMed  CAS  Google Scholar 

  38. Greaves MF (2006) Infection, immune responses and the aetiology of childhood leukemia. Nat Rev Cancer 6:193–203

    PubMed  CAS  Google Scholar 

  39. Greaves MF, Alexander FE (1993) An infectious etiology for common acute lymphoblastic leukemia in childhood? Leukemia 7:349–360

    PubMed  CAS  Google Scholar 

  40. Greenberg RS, Shuster JL, Jr (1985) Epidemiology of cancer in children. Epidemiology Rev 7:22–48

    CAS  Google Scholar 

  41. Greenland S, Sheppard AR, Kaune WT, Poole C, Kelsh MA (2000) A pooled analysis of magnetic fields, wire codes and childhood leukemia. Epidemiology 11:624–634

    PubMed  CAS  Google Scholar 

  42. Groves FD, Linet MS, Devesa SS (1995) Patterns of occurrence of the leukemias. Eur J Cancer 31A:941–949

    PubMed  CAS  Google Scholar 

  43. Gurney JG, Severson RK, Davis S, Robison LL (1995) Incidence of cancer in children in the United States. Cancer 75:2186–2195

    PubMed  CAS  Google Scholar 

  44. Higgins CD, dos-Santos-Silva I, Stiller CA, Swerdlow AJ (2001) Season of birth and diagnosis of children with leukaemia: An analysis of over 15000 UK cases occurring from 1953-1995. Br J Cancer 84:406–412

    PubMed  CAS  Google Scholar 

  45. Huebner WW, Wojcik NC, Roamilia K, Jorgensen G, Milano CA (2004) Mortality updates (1970–1997) of two refinery/petrochemical plant cohorts at Baton Rouge, Louisiana and Baytown, Texas. J Occup Environ Med 46:1229–1245

    PubMed  Google Scholar 

  46. Huret JL, Brizard A, Slater R, Charrin C, Bertheas MF, Guilhot F, et al. (1993) Cytogenetic heterogeneity in t(11;19) acute leukemia: Clinical, hematological and cytogenetic analyses of 48 patients — Updated published cases and 16 new observations. Leukemia 7:152–160

    PubMed  CAS  Google Scholar 

  47. Infante-Rivard C, Fortier I, Olson E (2000) Markers of infection, breast-feeding and childhood acute lymphoblastic leukaemia. Br J Cancer 83:1559–1564

    PubMed  CAS  Google Scholar 

  48. Infante-Rivard C, Labuda D, Krajinovic M, Sinnett D (1999) Risk of childhood leukemia associated with exposure to pesticides and with gene polymorphisms. Epidemiology 10:481–487

    PubMed  CAS  Google Scholar 

  49. International Agency for Research on Cancer (2005) IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. IARC Press, Lyon

    Google Scholar 

  50. Jablon S, Hrubec Z, Boice JD Jr (1991) Cancer in populations living near nuclear facilities. JAMA 265:1403–1408

    PubMed  CAS  Google Scholar 

  51. Jemal A, Siegel R, Ward E, Murray T, Xu J, Smigal C, et al. (2006) Cancer statistics, 2006. CA Cancer J Clin 56:106–130

    PubMed  Google Scholar 

  52. Jensen CD, Block G, Buffler P, Ma X, Selvin S, Month S (2004) Maternal dietary risk factors in childhood acute lymphoblastic leukemia (United States). Cancer Causes Control 15(6):559–570

    PubMed  Google Scholar 

  53. Katz F, Ball S, Gibbons B (1990) Acute lymphoblastic leukaemia in infancy: Clinical and biological features. Leuk Lymph 2:259

    Google Scholar 

  54. Kersey JH (1997) Fifty years of studies of the biology and therapy of childhood leukemia. Blood 90:4243–4251

    PubMed  CAS  Google Scholar 

  55. Kheifets L, Afifi AA, Buffler PA, Zhang Z, Matkin C (1997) Occupational electric and magnetic field exposure and leukemia. J Occup Environ Med 39:1074–1091

    PubMed  CAS  Google Scholar 

  56. Kinlen LJ (1988) Evidence for an infective cause of childhood leukemia: Comparison of a Scottish new town with nuclear reprocessing sites in Britain. Lancet ii:1323–1327

    Google Scholar 

  57. Kinlen LJ (1995) Epidemiological evidence for an infective basis in childhood leukemia [editorial]. Br J Cancer 71:1–5

    PubMed  CAS  Google Scholar 

  58. Kinlen LJ (2000) Infection, childhood leukemia and the Seascale cluster. Radiological Protection Bulletin 226:9–18

    Google Scholar 

  59. Kinlen LJ, Petridou E (1995) Childhood leukemia and rural population movements: Greece, Italy, and other countries. Cancer Causes Control. 6:445–450

    PubMed  CAS  Google Scholar 

  60. Kipen HM, Wartenberg D (2005) Lymphohematopoietic malignancies. In: Rosenstock L, Cullen MR, Brodkin CA, Redlich CA, (eds) Textbook of clinical occupational and environmental medicine. Elsevier Saunders, New York, pp 744–756

    Google Scholar 

  61. Knox EG, Gilman EA (1997) Hazard proximities of childhood cancers in Great Britain from 1953–1980. J Epidemiol Community Health 51:151–159

    PubMed  CAS  Google Scholar 

  62. Koushik A, King WD, McLaughlin JR (2001) An ecologic study of childhood leukemia and population mixing in Ontario, Canada. Cancer Causes Control 12:483–490

    PubMed  CAS  Google Scholar 

  63. Krieger N, Chen JT, Waterman P, Soobader M-J, Subramanian SV, Carson R (2002) Geocoding and monitoring of US socioeconomic inequalities in mortality and cancer incidence: Does the choice of area-based measure and geographic level matter? Am J Epidemiol 156:471–482

    PubMed  Google Scholar 

  64. Krivit W, Good RA (1957) Simultaneous occurrence of mongolism and leukemia. Am J Dis Children 94:289–293

    CAS  Google Scholar 

  65. Kwan ML, Block G, Selvin S, Month S, Buffler PA (2004) Food consumption by children and the risk of childhood acute leukemia. Am J Epidemiol 160:1098–1107

    PubMed  Google Scholar 

  66. Kwiatkowski A (1993) Dietary and other environmental risk factors in acute leukemias: A case-control study of 119 patients. Eur J Cancer Prev 2:139–146

    PubMed  CAS  Google Scholar 

  67. Land CE, McKay FW, Machado SG (1984) Childhood leukemia and fallout from the Nevada nuclear tests. Science 223:139–144

    PubMed  CAS  Google Scholar 

  68. Langholz B, Ebi K, Thomas C, Peters J, London S (2002) Traffic density and the risk of childhood leukemia in a Los Angeles case control study. Annals Epidemiol 12:482–487

    Google Scholar 

  69. Laplanche A, de Vathaire F (1994) Leukaemia mortality in French communes (administrative units) with a large and rapid population increase. Br J Cancer 69:110–113

    PubMed  CAS  Google Scholar 

  70. Laurier D, Grosche B, Hall P (2002) Risk of childhood leukaemia in the vicinity of nuclear installations-findings and recent controversies [Review]. [118 refs]. Acta Oncologica 41:14–24

    PubMed  Google Scholar 

  71. Laurier D, Valenty M, Tirmarche M (2001) Radon exposure and the risk of leukemia: A review of epidemiologic studies. Health Physics 81:272–288

    PubMed  CAS  Google Scholar 

  72. Lehtinen M, Koskela P, Ogmundsdottir HM, Bloigu A, Dillner J, Gudnadottir M, et al. (2003) Maternal herpes virus infection and risk of acute lymphoblastic leukemia in the offspring. Am J Epidemiol 158:207–213

    PubMed  Google Scholar 

  73. Lemen RA, Meinhardt TJ, Carndall MS, et al. (1990) Environmental epidemiologic investigations in the styrene-butadiene rubber production industry. Environ Health Perspect 86:103–106

    PubMed  CAS  Google Scholar 

  74. Lightfoot TJ, Roman E (2004) Causes of childhood leukemia and lymphoma. Toxicol Appl Pharmacol 199:104–117

    PubMed  CAS  Google Scholar 

  75. Linet MS, Cartwright R (1996) The Leukemias. In: Schottenfeld D, Fraumeni J, (eds) Cancer epidemiology and prevention. Oxford University Press, New York, pp 841–892

    Google Scholar 

  76. Linet MS, Hatch EE, Kleinerman RA, Robison LL, Kaune WT, Friedman DR, et al. (1997) Residential exposure to magnetic fields and acute lymphoblastic leukemia in children. N Engl J Med 337:1–7

    PubMed  CAS  Google Scholar 

  77. Linet MS, Wacholder S, Zahm SH (2003) Interpreting epidemiologic research: Lessons from studies of childhood cancer. Pediatrics 112:218–232

    PubMed  Google Scholar 

  78. Little J (1999) Epidemiology of childhood cancer. (No. 149). IARC. IARC Scientific Publications, Lyon, France

    Google Scholar 

  79. London S, Thomas D, Bowman JD, Sobel E, Cheng T-C, Peters J (1991) Exposure to residential electric and magnetic fields and risk of childhood leukemia. Am J Epidemiol 134:923–937

    PubMed  CAS  Google Scholar 

  80. Lyman G, Lyman C, Johnson W (1985) Association of leukemia with radium groundwater contamination. JAMA 254:621–626

    PubMed  CAS  Google Scholar 

  81. Lynge E, Anttila A, Hemminki K (1997) Organic solvents and cancer. Cancer Causes Control 8:406–419

    PubMed  CAS  Google Scholar 

  82. Lyon JL, Klauber MR, Gardner JW, Udall KS (1979) Childhood leukemias associated with fallout from nuclear testing. N Engl J Med 300:397–402

    PubMed  CAS  Google Scholar 

  83. Ma X, Buffler PA, Selvin S, Matthay KK, Wiencke JK, Wiemels JL, et al. (2002) Daycare attendance and risk of childhood acute lymphocytic leukaemia. Br J Cancer 86:1419–1424

    PubMed  CAS  Google Scholar 

  84. Machado SG, Land CE, McKay FW (1987) Cancer mortality and radioactive fallout in southwestern Utah. Am J Epidemiol 125: 44–61

    PubMed  CAS  Google Scholar 

  85. McKinney PA, Juszczak E, Findlay E, Smith K, Thomson CS (1999) Pre-and perinatal risk factors for childhood leukemia and other malignancies: A Scottish case control study. Br J Cancer 80: 1844–1851

    PubMed  CAS  Google Scholar 

  86. McLaughlin JR, King WD, Anderson TW, Clarke EA, Ashmore JP (1993) Paternal radiation exposure and leukemia in offspring: The Ontario case-control study. Br Med J 307:959–966

    CAS  Google Scholar 

  87. McMichael A, Spirtas R (1975) Solvent exposure and leukemia among rubber workers: An epidemiologic study. J Occup Med 17:234–239

    PubMed  CAS  Google Scholar 

  88. McNally RJQ, Eden TOB (2004) An infectious aetiology for childhood acute leukaemia: A review of the evidence. Br J Haematol 127:243–263

    PubMed  Google Scholar 

  89. Meinert R, Schuz J, Kaletsch U, Kaatsch P, Michaelis J (2000) Leukemia and non-Hodgkin’s lymphoma in childhood and exposure to pesticides: Results of a register-based case-control study in Germany. Am J Epidemiol 151:639–648

    PubMed  CAS  Google Scholar 

  90. Menegaux F, Baruchel A, Betrand Y, Lescoeur B, Leverger G, Nelken B, et al. (2006) Household exposure to pesticides and risk of childhood acute leukemia. Occup Environ Med 63:131–134

    PubMed  CAS  Google Scholar 

  91. Mikhail FM, Serry KA, Hatem N, Mourad ZI, Farawela HM, El Kaffash DM, et al. (2002) A new translocation that rearranges the AML1 gene in a patient with T-cell acute lymphoblastic leukemia. Cancer Genet Cytogenet 135:96–100

    PubMed  CAS  Google Scholar 

  92. Milham S (1982) Mortality from leukemia in workers exposed to electrical and magnetic fields. N Engl J Med 307:249

    PubMed  Google Scholar 

  93. Milham S (1985) Silent keys: Leukemia mortality in amateur radio operators. Lancet 1:812

    PubMed  Google Scholar 

  94. Morgan GJ, Cotter F, Katz FE, Ridge SA, Domer P, Korsmeyer S, et al. (1992) Breakpoints at 11q23 in infant leukemias with the t(11;19)(q23;p13) are clusters. Blood 80:2172–2175

    PubMed  CAS  Google Scholar 

  95. Mori H, Colman SM, Xiao Z, Ford AM, Healy LE, Donaldson C, et al. (2002) Chromosome translocations and covert leukemic clones are generated during normal fetal development. Proc Natl Acad Sci 99:8242–8247

    PubMed  CAS  Google Scholar 

  96. Muirhead CR, Kendall GM, Darby SC, Doll R, Haylock RG, O’Hagen JA, et al. (2004) Epidemiologic studies of UK test veterans: II. Mortality and cancer incidence. J Radiation Protection 24: 219–341

    CAS  Google Scholar 

  97. National Research Council (1990) Health effects of exposure to low levels of ionizing radiation. BEIR V. National Research Council Committee on the Biological Effects of Ionizing Radiation (eds) National Academy Press, Washington, DC

    Google Scholar 

  98. National Research Council (1997) Possible health effects of exposure to residential electric and magnetic fields. Committee on the Possible Effects of Electromagnetic Fields on Biologic Systems (eds) National Academy Press, Washington, DC

    Google Scholar 

  99. Naumberg E, Bellocco R, Cnattingius S, Honzon A, Ekbom A (2002) Perinatal exposure to infection and risk of childhood leukemia. Med Pediatr Oncol 38:391–397

    Google Scholar 

  100. NIEHS Working Group (1998) Assessment of health effects from exposure to power-line frequency electric and magnetic fields. Portier CJ, Wolfe MS. NIH Publication No. 98-3981,-508. Research Triangle Park, NC, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Public Health Service

    Google Scholar 

  101. Nordlinder R, Jarvholm B (1997) Environmental exposure to gasoline and leukemia in children and young adults — An ecologic study. Int Arch Occup Environ Health 70:57–60

    PubMed  CAS  Google Scholar 

  102. Pang D, McNally RJQ, Birch JM, United Kingdom childhood cancer study (2003) Parental smoking and childhood cancer: Results from the United Kingdom childhood cancer study. Br J Cancer 88:373–381

    PubMed  CAS  Google Scholar 

  103. Pearson RL, Wachtel H, Ebi KL (2000) Distance-weighted traffic density in proximity to a home is a risk factor for leukemia and other childhood cancers. J Air Waste Manage Assoc 50:175–180

    CAS  Google Scholar 

  104. Peters JM, Preston-Martin S, London SJ, Bowman JD, Buckley JD, Thomas DC (1994) Processed meats and risk of childhood leukemia. Cancer Causes Control 5:195–202

    PubMed  CAS  Google Scholar 

  105. Petridou E, Ntouvelis E, Dessypris N, Terzidis A, Trichopoulos D, the Childhood Hematology-Oncology Group (2005) Maternal diet and acute lymphoblastic leukemia in young children. Cancer Epidemiol Biomark Prev 14(8):1935–1939

    Google Scholar 

  106. Poole C, Greenland S, Luetters C, Kelsey JL, Mezei G (2006) Socioeconomic status and childhood leukemia: A review. Int J Epidemiol 35:370–384

    PubMed  Google Scholar 

  107. Preston DL, Kusumi S, Tomonaga M, Izumi S, Ron E, Kuramoto A, et al. (1994) Cancer incidence in atomic bomb survivors. Part III: Leukemia, lymphoma and multiple myeloma, 1950–1987. Radiat Res 137:S68–S97

    PubMed  CAS  Google Scholar 

  108. Pui CH, Crist WM, Look AT (1990) Biological and clinical significance of cytogenetic abnormalities in childhood acute lymphoblastic leukemia. Blood 76:1149–1163

    Google Scholar 

  109. Pui CH, Kane JR, Crist WM (1995) Biology and treatment of infant leukemias. Leukemia 9:762–769

    PubMed  CAS  Google Scholar 

  110. Raaschou-Nielsen O, Hertel O, Thomsen BL, Olsen JH (2001) Air pollution from traffic at the residence of children with cancer. Am J Epidemiol 153:433–443

    PubMed  CAS  Google Scholar 

  111. Raaschou-Nielsen O, Obel J, Dalton S, TjOnneland A, Hansen J (2004) Socioeconomic status and risk of childhood leukemia in Denmark. Scand J Public Health 32:279–286

    PubMed  Google Scholar 

  112. Raffini LJ, Slater DJ, Rappaport EF, Lo Nigro L, Cheung NK, Biegel JA, et al. (2002) Panhandle and reverse-panhandle PCR enable cloning of der(11) and der(other) genomic breakpoint junctions of MLL translocations and identify complex translocation of MLL, AF-4, and CDK6. Proc Natl Acad Sci 99:4568–4573

    PubMed  CAS  Google Scholar 

  113. Reynolds P, Elkin E, Scalf R, Von Behren J, Neutra RR (2001) A case-control pilot study of traffic exposures and early childhood leukemia using a geographic information systems. Bioelectromagnetics 5(Suppl):S58–S68

    PubMed  Google Scholar 

  114. Reynolds P, Gunier RB, Goldberg DE, Hertz A (2004) Residential exposure to traffic in California and childhood cancer. Epidemiology 15:6–12

    PubMed  Google Scholar 

  115. Reynolds P, Von Behren J, Gunier RB, Goldberg DE, Harnly ME, Hertz A (2005) Agricultural pesticide use and childhood cancer in California. Epidemiology 16:93–100

    PubMed  Google Scholar 

  116. Reynolds P, Von Behren J, Gunier RB, Goldberg DE, Hertz A, Smith DF (2003) Childhood cancer incidence rates and hazardous air pollutants in California: An exploratory analysis. Environ Health Perspect 111:663–668

    PubMed  CAS  Google Scholar 

  117. Ries LAG, Harkins D, Krapcho M, Mariotto A, Miller BA, Feuer EJ, Clegg L, Eisner MP, Horner MJ, Howlader N, et al. (2006) SEER Cancer Statistics Review, 1975–2003. Bethesda, MD, National Cancer Institute (http://seer.cancer.gov/csr/1975_2003)

    Google Scholar 

  118. Robison LL, Mertens A, Neglia JP (1991) Epidemiology and etiology of childhood cancer. In: Fernbach D, Vietti TJ, (eds) Clinical pediatric oncology. Mosby, St. Louis, pp 13–15

    Google Scholar 

  119. Ross JA (1998) Maternal diet and infant leukemia: A role for DNA topoisomerase II inhibitors? Int J Cancer 11(Suppl):26–28

    CAS  Google Scholar 

  120. Ross JA, Davies SM, Potter JD, Robison LL (1994) Epidemiology of childhood leukemia, with a focus on infants. Epidemiology Rev 16:243–272

    CAS  Google Scholar 

  121. Ross JA, Kasum CM, Davies SM, Jacobs DR, Folsom AR, Potter JD (2002) Diet and risk of leukemia in the Iowa Women’s Health Study. Cancer Epidemiol Biomark Prev 11:777–781

    Google Scholar 

  122. Ross JA, Potter JD, Reaman GH, Pendergrass TW, Robison LL (1996) Maternal exposure to potential inhibitors of DNA topoisomerase II and infant leukemia (United States): A report from the Children’s Cancer Group. Cancer Causes Control 7(6): 581–590

    PubMed  CAS  Google Scholar 

  123. Ross JA, Severson RK, Swensen AR, Pollock BH, Gurney JG, Robison LL (1999) Seasonal variations in the diagnosis of childhood cancer in the United States. Br J Cancer 81:549–553

    PubMed  CAS  Google Scholar 

  124. Ross JA, Spector LG, Davies SM (2005) Biological basis of cancer and blood disorder. Etiology of childhood cancer: Recent reports. Pediatr Blood Cancer 45:239–241

    PubMed  Google Scholar 

  125. Rubnitz JE, Downing JR, Pui CH, Shurtleff SA, Raimondi SC, Evans WE, et al. (1997) TEL gene rearrangement in acute lymphoblastic leukemia: A new genetic marker with prognostic significance. Clin Oncol 15:1150–1157

    CAS  Google Scholar 

  126. Sandler DP, Ross JA (1997) Epidemiology of acute leukemia in children and adults. Semin Oncol 24:3–16

    PubMed  CAS  Google Scholar 

  127. Sandler DP, Ross JA (1997) Epidemiology of acute leukemia in children and adults. [Review] [223 refs]. Semin Oncol 24(1): 3–16

    PubMed  CAS  Google Scholar 

  128. Sarasua S, Savitz DA (1994) Cured and broiled meat consumption in relation to childhood cancer. Cancer Causes Control 5:141–148

    PubMed  CAS  Google Scholar 

  129. Savitz DA, Feingold L (1989) Association of childhood cancer with residential traffic density. Scand J Work Env Health 15: 360–363

    CAS  Google Scholar 

  130. Savitz DA, Loomis DP (1995) Magnetic field exposure in relation to leukemia and brain cancer mortality among electric utility workers. Am J Epidemiol 141:123–134

    PubMed  CAS  Google Scholar 

  131. Savitz DA, Wachtel H, Barnes FA, John EM, Tvrdik JG (1988) Casecontrol study of childhood cancer and exposure to 60-Hertz magnetic fields. Am J Epidemiol 128:21–38

    PubMed  CAS  Google Scholar 

  132. Schuz J, Kaletsch U, Meinert R, Kaatsch P, Michaelis J (2000) Risk of childhood leukemia and parental self-reported occupational exposure to chemicals, dusts, and fumes: Results from pooled analyses of German population-based case-control studies. Cancer Epidemiol Biomark Prev 9:835–838

    CAS  Google Scholar 

  133. Schuz J, Spector LG, Ross JA (2003) Bias in studies of parental self-reported occupational exposure and childhood cancer. Am J Epidemiol 158:710–716

    PubMed  Google Scholar 

  134. Shu XO, Gao Y-T, Brinton LA, et al. (1988) A population-based case-control study of childhood leukemia in Shanghai. Cancer 62:934–937

    Google Scholar 

  135. Shu XO, Stewart P, Wen W-Q, Han D, Potter J, Buckley JD, et al. (1999) Parental occupational exposure to hydrocarbons and risk of acute lymphocytic leukemia in offspring. Cancer Epidem Biomark Prev 8:783–791

    CAS  Google Scholar 

  136. Smith M (1997) Considerations on a possible viral etiology for B-precursor acute lymphoblastic leukemia of childhood. J Immunother 20:89–100

    PubMed  CAS  Google Scholar 

  137. Smith MA, Simon R, Strickler HD, McQuillan G, Ries LAG, Linet MS (1998) Evidence that childhood acute lymphoblastic leukemia is associated with an infectious agent linked to hygiene conditions. Cancer Causes Control 9:285–298

    PubMed  CAS  Google Scholar 

  138. Sorensen HT, Pedersen L, Olsen J, Rothman K (2001) Seasonal variation in month of birth and diagnosis of early childhood acute lymphoblastic leukaemia. JAMA 285:168–169

    PubMed  CAS  Google Scholar 

  139. Spector LG, Groves FD, DeStefano F, Liff J, Klein M, Mullooly J, et al. (2004) Medically recorded allergies and the risk of childhood acute lymphoblastic leukemia. Eur J Cancer 40:579–584

    PubMed  CAS  Google Scholar 

  140. Spector LG, Xie Y, Robison LL, Heerema NA, Hilden JM, Lange B, et al. (2005) Maternal diet and infant leukemia: The DNA topoisomerase II inhibitor hypothesis: A report from the children’s oncology group. Cancer Epidemiol Biomark Prev 14(3):651–655

    CAS  Google Scholar 

  141. Stagnaro E, Ramazzotti V, Crosignani P, Fontana A, Masala G, Miligi L, et al. (2001) Smoking and hematolymphopoietic malignancies. Cancer Causes Control 12:325–334

    PubMed  CAS  Google Scholar 

  142. Steffen C, Auclerc MF, Auvrignon A, Baruchel A, Kebaili K, Lambilliotte A, et al. (2004) Acute childhood leukaemia and environmental exposure to potential sources of benzene and other hydrocarbons; a case-control study. Occup Env Med 61(9):773–778

    CAS  Google Scholar 

  143. Stevens W, Thomas DC, Lyon JL, Till JE, Kerber RA, Simon SL, et al. (1990) Leukemia in Utah and radioactive fallout from the Nevada test site. JAMA 264:585–591

    PubMed  CAS  Google Scholar 

  144. Stewart A, Webb J, Hewitt D (1958) A survey of childhood malignancies. Br Med J 28:1497–1507

    Google Scholar 

  145. Swensen AR, Ross JA, Severson RK, Pollock BH, Robison LL (1997) The age peak in childhood acute lymphoblastic leukemia. Cancer 79:2045–2051

    PubMed  CAS  Google Scholar 

  146. The Leukemia and Lymphoma Society (2005) Acute lymphocytic leukemia. The Leukemia and Lymphoma Society, White Plains, NY

    Google Scholar 

  147. Theriault GP, Goldberg M, Miller AB, Armstrong B, Guenel P, Deadman J, et al. (1994) Cancer risks associated with occupational exposure to magnetic fields among electric utility workers in Ontario and Quebec, Canada, and France: 1970–1989. Am J Epidemiol 139:550–572

    PubMed  CAS  Google Scholar 

  148. Tomenius L (1986) 50-Hz electromagnetic environment and the incidence of childhood tumors in Stockholm County. Bioelectromagnetics 7:191–207

    PubMed  CAS  Google Scholar 

  149. Viel J-E, Richardson S, Danel P, Boutard P, Malet M, Barrelier P, et al. (1993) Childhood leukemia incidence in the vicinity of La Hague nuclear waste reprocessing facility (France). Cancer Causes Control 4:341–343

    PubMed  CAS  Google Scholar 

  150. Visser O, van Wijnen JH, van Leeuwen FE (2004) Residential traffic density and cancer incidence in Amsterdam, 1989–1997. Cancer Causes Control 15(4):331–339

    PubMed  Google Scholar 

  151. Wartenberg D (2001) Residential EMF exposure and childhood leukemia: Meta-analysis and population attributable risk. Bioelectromagnetics 5(Suppl):S86–S104

    PubMed  Google Scholar 

  152. Wartenberg D, Reyner D, Scott CS (2000) Trichloroethylene and cancer: The epidemiologic evidence. Environ Health Perspect 108(Suppl 2):161–176

    PubMed  CAS  Google Scholar 

  153. Wartenberg D, Schneider D, Brown S (2004) Childhood leukemia incidence and the population mixing hypothesis in US SEER data. Br J Cancer 90:1771–1776

    PubMed  CAS  Google Scholar 

  154. Wen W, Shu XO, Linet MS, Neglia JP, Potter JD, Trigg ME, et al. (2000) Allergic disorders and the risk of childhood acute lymphoblastic leukemia (United States). Cancer Causes Control 11(4): 303–307

    PubMed  CAS  Google Scholar 

  155. Wen W, Shu XO, Potter JD, Severson RK, Buckley JD, Reaman GH, et al. (2002) Parental medication use and risk of childhood acute lymphoblastic leukemia. Cancer 95(8):1786–1794

    PubMed  Google Scholar 

  156. Wertheimer N, Leeper E (1979) Electrical wiring configurations and childhood cancer. Am J Epidemiol 109:273–284

    PubMed  CAS  Google Scholar 

  157. Westerbeek RMC, Blair V, Eden OB, Kelsey AM, Stevens RF, Will AM, et al. (1998) Seasonal variations in the onset of childhood leukaemia and lymphoma. Br J Cancer 78:119–124

    PubMed  CAS  Google Scholar 

  158. Wong O, Harris F, Rosamilia K, Raabe GK (2001) Updated mortality study of workers at a petroleum refinery in Torrance, California, 1959–1997. J Occup Environ Med 43:1089–1102

    PubMed  CAS  Google Scholar 

  159. Yoshimoto Y (1990) Cancer risk among children of atomic bomb survivors: A review of RERF epidemiologic studies. JAMA 264: 596–600

    PubMed  CAS  Google Scholar 

  160. Yoshimoto Y, Kato H, Schull WJ (1988) Risk of cancer among children exposed in utero to A-bomb radiations, 1950–1984. Lancet 2:665–669

    PubMed  CAS  Google Scholar 

  161. Yoshimoto Y, Neel JV, Schull WJ, et al. (1990) Malignant tumors during the first 2 decades of life in the offspring of atomic bomb survivors. Am J Hum Genet 46:1040–1052

    Google Scholar 

  162. Zuelzer WW (1964) Implications of long-term survivals in acute stem cell leukemia of childhood treated with composite cyclic therapy. Blood 24:477–494 (as cited by The Leukemia and Lymphoma Society 2005)

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Environmental and Occupational Medicine, Robert Wood Johnson Medical School, Piscataway, NJ, USA

    Daniel Wartenberg

  2. Department of Epidemiology and Population Health School of Public Health and Information Sciences, University of Louisville, Louisville, KY, USA

    Frank D. Groves

  3. Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, Charleston, SC, USA

    Aaron S. Adelman

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  1. Daniel Wartenberg
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  2. Frank D. Groves
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  3. Aaron S. Adelman
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Wartenberg, D., Groves, F.D., Adelman, A.S. (2008). Acute Lymphoblastic Leukemia: Epidemiology and Etiology. In: Acute Leukemias. Hematologic Malignancies. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-72304-2_5

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